Foreword (M. Eric Gershwin and Yehuda Shoenfeld)
.
Part I: New Principles of Autoimmunity.
1. The Nature and Nurture of Common Autoimmunity (John
Castiblanco and Juan-Manuel Anaya).
2. Designed Ankyrin Repeat Proteins as Anti-Idiotypic Binding
Molecules (Monique Vogel, Elsbeth Keller-Gautschi, Michael J.
Baumann, Patrick Amstutz, Christine Ruf, Franz Kricek, Beda M.
Stadler).
3. SLAM-Associated Protein (SAP) Solves a Mystery of
Autoimmunity: (Shigemasa Sawada, Masami Takei, Tetsuyosi Ishiwata,
Hidetaka Shiraiwa, Hirotake Inomata, Takamasa Nozaki).
4. Standardization of Autoimmune Diagnostics in Germany ?
Activities of the German Group in the European Autoimmune
Standardisation Initiative (Ulrich Sack, Karsten Conrad, Elena
Csernok, Ingrid Frank, Michael Haass, Torsten Krieger, Michael
Seyfarth, Udo Schlosser, Reinhold E. Schmidt, Torsten Witte).
5. Autoimmunity and Time Entanglement (Juan I. Poo, Pablo I.
Martin, Enrique Rewald).
6. The Pro- and Anti-Inflammatory Potential of Interleukin-12
(Hyun-Dong Chang, Andreas Radbruch).
7. NKG2D and Natural Cytotoxicity Receptors Are Involved in
Natural Killer Cell Interaction with Self-Antigen Presenting Cells
and Stromal Cells (Poggi Alessandro, Prevosto Claudia, Zancolli
Marta, Paolo Canevali, Alessandra Musso, Zocchi Maria
Raffaella).
8. The Role of Toll-Like Receptors in HMGB1 Release from
Macrophages (David S. Pisetsky, Weiwen Jiang).
9. Immune Complex Pathophysiology (Urs E. Nydegger).
10. Human Proteinase 3 (PR3) and Its Binding Molecules:
Implications for Inflammatory and PR3-Related Autoimmune Responses
(Antje Muller, Jan Voswinkel, Stefan Gottschlich, Elena
Csernok).
11. Loss of Self-Control in the Complement System and Innate
Autoreactivity (Seppo Meri).
12. Immunodeficiency and Autoimmune Phenomena in Female Hyper
IgM Syndrome (HIGM) (Melegari Alessandra, Mascia Maria Teresa,
Sandri Gilda, Carbonieri Anna).
13. Autoimmune Diseases of Domestic Animals (Laurel J.
Gershwin).
14. Prediction and Prevention of Autoimmune Disease: A Personal
Perspective (Noel R. Rose).
15. Alterations of Th1/Th2 Reactivity by Heavy Metals: Possible
Consequences Include Induction of Autoimmune Diseases (Nasr Y.A.
Hemdan, Frank Emmrich, Sonya Faber, Ulrich Sack).
16. EASI ? The European Autoimmunity Standardisation
Initiative: A New Initiative That Can Contribute to Agreed
Diagnostic Models of Diagnosing Autoimmune Disorders Throughout
Europe (Yehuda Shoenfeld, Ricard Cervera, Michael Haass, Cees
Kallenberg, Munther Khamashta, Pier Luigi Meroni, Jean-Charles
Piette, Reinhold Schmidt, Allan Wiik).
17. Effector Memory CD8+ T Cells Are Resistant to Apoptosis
(Sudhir Gupta, Sastry Gollapudi).
18. Two-Step Mechanism of Virus-Induced Autoimmune Hemolytic
Anemia (Jean-Paul Coutelier, Laurent Detalle, Andrei Musaji, Mory
Meite, Shozo Izui).
19. Autoimmune Reactions After Electro-Oxidation of IgG from
Healthy Persons. Relevance of Electric Current and Antioxidants
(Borut Bozic, Sasa Cucnik, Tanja Kveder, Blaz Rozman).
20. Autoimmune Diseases Are Connected With Disturbances In
Cytokine Synthesis and Therapy With IFN-g Blockers Is Their Main
Pathogenetic Treatment (Boris Skurkovich, Simon
Skurkovich).
Part II: New Tools in Diagnosis.
21. Screening of Endothelial Expression Libraries for the
Identification of Novel Autoantigens Involved in Distinct
Autoimmune Diseases Characterized by Endothelial Dysfunction (Paola
Margutti, Federica Delunardo, Tania Colasanti, Ettore Piro,
Elisabetta Profumo, Rachele Riganò, Alessandra Siracusano,
Brigitta Buttari, Fabrizio Conti, Cristiano Alessandri, Antonella
Capozzi, Maurizio Sorice, Elena Ortona).
22. Diagnosing Diseases by Mesurement of Electrical Skin
Impedance: A Novel Technique (Rony Weitzen, Nava Epstein, Yehuda
Shoenfeld, Eyal Zimlichman).
23. Antigen Preparation for Immunological Studies in Systemic
Autoimmune Diseases (Sandra Zampieri, Anna Ghirardello, Katia
Rossini, Luca Iaccarino, Nicola Bassi, Fabiola Atzeni, PierCarlo
Sarzi-Puttini, Andrea Doria).
24. Comparison of Two Elisa Assays for Anti-SP100 Determination
(Jose Manuel Lucena, Marcos Montes Cano, Jose Luis Caro,
Nieves Respaldiza, Antonia Alvarez, Julio Sanchez-Roman,
Antonio Nunez-Roldan, Ingeborg Wichmann).
25. Diagnostic Accuracy of IgA Anti-Tissue Transglutaminase
Antibody Assays in Celiac Disease Patients with Selective IgA
Deficiency (D. Villalta, M.G. Alessio, M. Tampoia, E. Tonutti, I.
Brusca, M. Bagnasco, G. Pesce, N. Bizzaro).
26. Anti-Topoisomerase 1 Antibodies in Systemic Sclerosis: How
to Improve the Detection (Mathieu C. Tamby, Guillaume Bussone, Luc
Mouthon).
27. The Effect of Open Heart Surgery on Tuberculin Skin Test
Reactivity (Michal Stein, Batia Sela-Razon, Ilan Linder, Eli
Somekh).
28. The Reliability of Control Skin Tests with Common Antigens
in Children Undergoing Tuberculin Skin Test (Michal Stein, Batia
Sela-Razon, Yeshayaou Kleter, Eli Somekh).
29. Ena Screen Chemiluminescence Immunoassay: A Random Access
Method in Autoimmunology (S. Signorini, I. Kutschera, F. Capuano,
L. Lattuada).
30. Evaluation of the BioPlex 2200? ANA Screen for the
Detection of Anti-Nuclear Antibodies and Comparison with
Conventional Methods (Sophie Desplat-Jego, Nathalie Bardin, Bruno
Larida, Marielle Sanmarco).
31. A New Line Immunoassay for the Multiparametric Detection of
Anti-Ganglioside Autoantibodies in Patients with Autoimmune
Peripheral Neuropathies (Karsten Conrad, Hauke Schneider, Tjalf
Ziemssen, Thomas Talaska, Dirk Reinhold, Rene-Louis Humbel, Dirk
Roggenbuck).
32. Lipocalin-2, Tweak and Other Cytokines as Urinary Biomarkers
for Lupus Nephritis (Noa Schwartz, Jennifer S. Michaelson, Chaim
Putterman).
33. The Prevalence of Anti-Nucleosome Antibodies by
Enzyme-Linked Immunosorbent Assays (ELISA) in Patients with
Systemic Lupus Erythematosus and Other Autoimmune Systemic Diseases
(I. Putova, C. Dostal, R. Becvar).
34. Predictive Value of Antibodies to Citrullinated Peptides and
Rheumatoid inbFactors Treated Patients (Francesca
Bobbio-Pallavicini, Roberto Caporali, Anti-TNF- Claudia Alpini,
Remigio Moratti, Carlomaurizio Montecucco).
35. Redox-Reactive Autoantibodies in Cerebrospinal Fluids (John
A. McIntyre, Ronald L. Hamilton, Steven T. DeKosky).
36. Determination of Oxidized Low-Density Lipoproteins 2GPI
Complexes for the (OxLDL) Versus OxLDL/ Atherosclerosis (Luis
R.bAssessment of Autoimmune-Mediated Lopez, Tammmy R. Buckner, Beth
L. Hurley, Kazuko Kobayashi, Eiji Matsuura).
37. Serological and Clinical Characterization of Anti-dsDNA and
Anti-PM/Scl Double Positive Patients (M. Mahler, E.L. Greidinger,
M. Szmyrka, A. Kromminga, M.J. Fritzler).
38. Performance of ANA CTD Screen as Screening for Connective
Tissue Diseases (Marcos Lopez-Hoyos, Vicente
Rodriguez-Valverde, Victoria Martinez-Taboada).
39. Multiplex Assays to Diagnose Celiac Disease (Ivo Lochman,
Peter Martis, Rufus W. Burlingame, Alexandra Lochmanova).
40. Could Serum Antibody to Poly(ADP-ribose) and/or Histone H1
be Marker for Senile Dementia of Alzheimer Type (Y. Kanai, H.
Akatsu, H. Iizuka, C. Morimoto).
41. Identification by Proteomic Tool of Atypical
Anti-Liver/Kidney-Microsome Autoantibodies Targets in de novo
Auto-Immune Hepatitis After Liver Transplantation (S. Huguet, J.
Vinh, C. Johanet, D. Samuel, M. Gigou, O. Zamfir, J.C.
Duclos-Vallee, E. Ballot).
42. Automatic Analysis of Immunofluorescence Patterns of HEP-2
Cells (Rico Hiemann, Nadja Hilger, Jorg Michel, Jorg
Nitschke, Alexander Bohm, Ursula Anderer, Martin Weigert,
Ulrich Sack).
43. Exploring cDNA Phage Display for Autoantibody Profiling in
Serum of Multiple Sclerosis Patients: Optimization of the Selection
Procedure (C. Govarts, K. Somers, R. Hupperts, P. Stinissen, V.
Somers).
44. Novel Biomarkers in Autoimmune Diseases Prolactin, Ferritin,
Vitamin D and TPA Levels in Autoimmune Diseases (Hedi Orbach,
Gisele Zandman-Goddard, Howard Amital, Vivian Barak, Zoltan
Szekanecz, Gabriella Szucs, Katalin Danko, Endre Nagy, Tunde
Csepany, Jozelio F. Carvalho, Andrea Doria, Yehuda Shoenfeld).
45. Evaluation of Current Methods for the Measurement of Serum
Anti-Double Stranded DNA Antibodies (Anna Ghirardello, Danilo
Villalta, Gabriella Morozzi, Antonella Afeltra, Mauro Galeazzi,
Robert Gerli, Alessandro Mathieu, Pier Luigi Meroni, Paola
Migliorini, Antonella Radice, Valeria Riccieri, Amelia Ruffatti,
Gian Domenico Sebastiani, Angela Tincani, Andrea Doria).
46. Evaluation of the Liaison ANA Screen Assay for Antinuclear
Antibody Testing in Autoimmune Diseases (P. Ghillani, A.M.
Rouquette, C. Desgruelles, N. Hauguel, C. Le Pendeven, J.C. Piette,
L. Musset).
47. Clinical Significance of Anti-Histidyl-tRNA Synthetase (Jo1)
Autoantibodies (Emeline Gomard-Mennesson, Nicole Fabien,
Jean-Francois Cordier, Jacques Ninet, Jacques Tebib, Hugues
Rousset).
48. Antinucleosome Antibodies and Systemic Lupus Erythematosus
(Nursen Duzgun, Mehmet Sahin, Yasemin Genç,
Huseyin Tutkak).
49. Protein Expression Profile of Celiac Disease Patient with
Aberrant T-Cell By Two-Dimensional Difference Gel Electrophoresis
(Valli De Re, Maria Paola Simula, Laura Caggiari, Nicoletta Ortz,
Michele Spina, Alessandro Da ponte, Leandro De Appolonia, Riccardo
Dolcetti, Vincenzo Canzonieri, Renato Cannizzaro).
50. The Chemokine Profile of the Different Inflammatory
Myopathies Reflects the Humoral Versus Cytotoxic Immune Responses
(Boel De Paepe, Kim K. Creus, Jan L De Bleecker).
51. Evaluation of the FIDIS Multiplex Immunoassay for Diagnosis
and Follow-Up of ANCA-Associated Vasculitis and Goodpasture?s
Disease (J. Damoiseaux, M. Vaessen, Y. Knapen, E. Csernok, C.A.
Stegeman, P. van Paassen, J.W. Cohen Tervaert).
52. Comparison of Three Multiplex Immmunoassays for Detection of
Antibodies to Extractable Nuclear Antibodies Using Clinically
Defined Sera (Susan S. Copple, Thomas B. Martins, Charlin
Masterson, Erwann Joly, Harry R. Hill).
53. Identification of Histidine-Rich Glycoprotein, a Potential
Autoantigen, in Human and Rat Brain Preparations (Catrin
Ball-Rosen, Hagit Primak-Rubinovicz, Amos D. Korczyn, Ningshan
Wang, Adel Farchi, Sara Shavit, Yehuda Shoenfeld, Joab
Chapman).
54. An Analysis of Experimental 2Glycoprotein I Elisa Assay
Results: Conditions Influencing the Anti- (Anna Cavazzana, Amelia
Ruffatti, Marta Tonello,bAnna Maria Bortolati, Philippe de
Moerloose, Guido Reber).
55. Development of Automated Assays for Anti Cardiolipin
Antibodies Determination: Addressing Antigen/Solid-Phase and
Standardization Issues (Francesco Capuano, Valentina Grasso, L.
Belforte, Luca Pallavicini, Fabrizio Bonelli).
56. Biological and Clinical Relevance of Anti-Prothrombin
Antibodies (Anna Ghirardello, Nicola Bizzaro, Sandra Zampieri, Luca
Iaccarino, Nicola Bassi, Renato Tozzoli, Amelia Ruffatti, Danilo
Villalta, Elio Tonutti, Andrea Doria).
57. Clinical Evaluation of a New Quantitative Enzyme Linked
Immunosorbent Assay for Detection of Double Stranded DNA
Autoantibodies (Nathalie Bardin, Celine Ragot, Marielle
Sanmarco).
58. Characterization of Autoantibodies Against Components of the
Nuclear Pore Complexes: High Frequency of Anti-p62 Nucleoporin
Antibodies (Jozefa Wesierska-Gadek, Anna Klima, Oxana Komina,
Carmen Ranftler, Pietro Invernizzi, Edward Penner).
59. Anti-Cardiolipin and Anti-Beta2Glycoprotein-I Antibdies:
Performance of New Commercial Elisa Kits (Laura Andreoli, Fabio
Malacarne, Angela Ceribelli, Iris Kutschera, Angela Tincani).
60. A Combined SDS-PAGE and Proteomics Approach to Identify
Target Autoantigens in Healthy Individuals and Patients with
Autoimmune Diseases (Philippe Guilpain, Amelie Servettaz,
Mathieu C. Tamby, Youri Chanseaud, Nicolas Tamas, Paloma Garcia de
la Pena-Lefebvre, Cedric Broussard, Luc Camoin, Luc
Mouthon).
61. Anti-Vitamin D, Vitamin D in SLE: Preliminary Results
(Jozelio Freire de Carvalho, Miri Blank, Emese Kiss, Tunde
Tarr, Howard Amital, Yehuda Shoenfeld).
Index of Contributors.
