
Charney and Nestler's Neurobiology of Mental Illness
By: Dennis Charney (Editor), Eric Nestler (Editor), Joseph D. Buxbaum (Editor), Elisabeth B. Binder (Editor), Joshua A. Gordon (Editor)
Hardcover | 3 January 2025 | Edition Number 6
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1104 Pages
Revised
28.2 x 22.3 x 5.3
Hardcover
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Collectively, the 75 chapters in this newly renovated textbook describe the developments in genetics and in molecular, cellular, and systems neuroscience that are breaking new ground in the diagnosis, treatment, and prevention of disabling psychiatric disorders.
In this updated edition, Section 1 focuses on the major methodological approaches to studying the biological basis of mental illness. Sections 2 through 8 each focus on a major class of mental illness, including schizophrenia, bipolar disorder, depression, anxiety and trauma disorders, substance use disorders, neurodegenerative disorders, and childhood psychiatry disorders.
The final section is a collection of essays that address what can be expected over the next decade in terms of improving psychiatric diagnosis, achieving a true precision approach to treating mental illness, along with new avenues of medication and non-medication therapies in the offing.
1. Genetic Methodologies and Applications Ben Neale
2. Multiscale Network Approaches to Decode the Complexity of Common Human Diseases Minghui Wang, Yiyuan Liu, Eric Schadt, and Bin Zhang
3. The Role of the Epigenome in Brain Development, Function, and Disease Schahram Akbarian, John F. Fullard, Kiran Girdhar, and Panos Roussos
4. Methods for In Vivo Gene Manipulation Lisa M. Monteggia and Wei Xu
5. Application of Stem Cells to Understanding Psychiatric Disorders Marcella, Burtele, Giorgia Quadrato, and Kristen Brennand
6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges Lief E. Fenno and Karl Deisseroth
7. Methods for In Vivo Circuit Analysis Micah Johnson, Yassine Filali, Radha Velamuri, Kafui Dzirasa, and Rainbo Hultman
8. Magnetic Resonance Methodologies Hanzhang Lu and Peter A. Bandettini
9. PET Brain Imaging Methodologies Ansel Hillmer, Kelly P. Cosgrove, and Richard E. Carson
10. Neuromodulation and Psychiatric Disorders Andrew Smith, Martijn Figee, and Helen Mayberg
SECTION 2: SCHIZOPHRENIA Section Editors: Judy Ford and Dan Mathalon
11. Diagnosis and Epidemiology of Schizophrenia Julie Walsh-Messinger, Ariella Farzan Nikou, and Dolores Malaspina
12. Genetics of Schizophrenia Sophie E. Legge, Antonio F. Pardiñas, and Michael C. O'Donovan
13. Neuroimaging and Circuit Mechanisms of Schizophrenia Neil D. Woodward, Stephan Heckers, Dost Ongur, and Julia M. Sheffield
14. Animal and Cellular Models for the Study of Schizophrenia Joshua A. Gordon
15. Neural and Circuit Mechanisms of Schizophrenia Samuel J. Dienel and David A. Lewis
16. Glial-Immune Mechanisms of Schizophrenia: Animal and Human Studies Kowsar Teymouri, Mahbod Ebrahimi, Jennie G. Pouget, and James L. Kennedy
17. Translational Models for Psychotic Symptoms Phil Corlett
18. Current Treatments for Schizophrenia Donald C. Goff
19. Novel Approaches for Treating Schizophrenia Steve M. Paul and Alan Breier
SECTION 3: BIPOLAR DISORDER Section Editor: Alex Charney
20. Diagnosis and Epidemiology of Bipolar Disorder Kathleen R. Merikangas and Emma K. Stapp
21. Genetics of Bipolar Disorder Dongjing Liu and Niamh Mullins
22. Neuroimaging and Circuit Mechanisms of Bipolar Disorder E. Kale Edmiston, Michele A. Bertocci, Merage Ghane-Ezabadi, and Mary L. Phillips
23. Animal and Cellular Models for the Study of Bipolar Disorder Michael J. McCarthy and Jared W. Young
24. Molecular and Cellular Mechanisms of Bipolar Disorder: Animal and Human Studies Colleen A. McClung and Hilary P. Blumberg
25. Current Treatments for Bipolar Disorder Nicole W. Simons and Alexander W. Charney
26. Novel Approaches for Treating Bipolar Disorder Nefize Yalin, Allan H. Young, and Carlos A. Zarate, Jr.
SECTION 4: DEPRESSION Section Editor: John Krystal
27. Diagnosis and Epidemiology of Depression James W. Murrough
28. Genetics of Depression Daniel Levey and Joel Gelernter
29. Neuroimaging and Circuit Mechanisms of Depression Adrienne L. Romer, Michele A. Bertocci, Mary L. Phillips, and Diego A. Pizzagalli
30. Animal Models for the Study of Depression Lyonna F. Parise, Astrid M. Cardona-Acosta, Eric M. Parise, and Carlos A. Bolaños-Guzmán
31. Neurotrophic Mechanisms of Depression: Animal and Human Studies Lisa M. Monteggia
32. Glial-Immune Mechanisms of Depression: Animal and Human Studies Georgia E. Hodes, Caroline Ménard, Madeline L. Pfau, and Scott J. Russo
33. Neuroendocrine Mechanisms of Depression: Animal and Human Studies Elisabeth B. Binder and Jan M. Deussing
34. Current Treatments for Depression Maurizio Fava and John Krystal
35. Novel Approaches for Treating Depression Eric J. Nestler, Dennis S. Charney, John H. Krystal, and James W. Murrough
SECTION 5: ANXIETY AND TRAUMA-RELATED DISORDERS Section Editor: Kerry J. Ressler
36. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive, and Trauma- and Other Stress-Related Disorders Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne
37. Genetics of Anxiety and Trauma-Related Disorders Sarah E. Benstock and John M. Hettema
38. Neuroimaging and Circuit Mechanisms of Anxiety and Trauma-Related Disorders Gregory A. Fonzo
39. Animal Models for the Study of Anxiety Disorders Caroline Jia, Hao Li, and Kay Tye
40. Biological Mechanisms of Anxiety Disorders: Animal and Human Studies Danielle M. Gerhard, Anfei Li, Francis S. Lee, and Heidi C. Meyer
41. Biological Mechanisms of Stress Resilience: Animal and Human Studies Saren H. Seeley, Sarah Boukezzi, Jonathan DePierro, Dennis S. Charney, and Adriana Feder
42. Current Treatments for Anxiety and Trauma-Related Disorders Kristin L. Szuhany, Benjamin Feldman, Matteo Malgaroli, and Naomi M. Simon
43. Novel Approaches for Treating Anxiety and Trauma-Related Disorders Alfred P. Kaye, Sarah Jefferson, and John H. Krystal
SECTION 6: SUBSTANCE USE DISORDERS Section Editors: Nora Volkow and Yavin Shaham
44. Epidemiology of Substance Use Disorders Denise B. Kandel, Pamela C. Griesler, Mei-Chen Hu, Philippe A. Melas, Bradley T. Kerridge, and Bridget F. Grant
45. Genetics of Substance Use Disorders David Goldman and Danielle Sambo
46. Neuroimaging and Circuit Mechanisms of Substance Use Disorders Edythe D. London, Chelsea L. Robertson, and Terry J. Prins
47. Animal Models for the Study of Substance Use Disorders Christopher J. Evans, J. David Jentsch, Brigitte L. Kieffer, Rafael J. Maldonado, and Catherine M. Cahill
48. Cellular and Molecular Mechanisms of Substance Use Disorders: Animal and Human Studies Kathryn J. Reissner
49. Brain Development and the Risk for Substance Use Disorders Sonia G. Ruiz, B.J. Casey, and Arielle Baskin-Sommers
50. Current Treatments for Substance Use Disorders Adam D'Sa, Andrew L. Gaddis, and Eric C. Strain
51. Novel Approaches for Treating Substance Use Disorders Matthew L. Banks
SECTION 7: DEMENTIA Section Editor: Alison M. Goate
52. Diagnosis and Epidemiology of Dementia William C. Kreisl and Christiane Reitz
53. Genetics of Alzheimer's Disease, Parkinson's Disease, and Lewy Body Dementia Alan E. Renton, Brian Fulton-Howard, Shea J. Andrews, Edoardo Marcora, and Alison M. Goate
54. Neuroimaging and Fluid Biomarkers of Alzheimer's Disease Brian A. Gordon and Suzanne Schindler
55. Molecular and Cellular Mechanisms of Alzheimer's Disease: Animal and Human Studies Gareth R. Howell and Gregory W. Carter
56. Molecular and Cellular Mechanisms of Primary Tauopathies: Animal and Human Studies Shiaoching Gong and Li Gan
57. Neurobiology of Lewy Body Dementias: Animal and Human Studies James E. Galvin and Jose Tomas Bras
58. Current Treatments for Alzheimer's Disease and Other Dementias Mary Sano and Judith Neugroschil
59. Novel Approaches for Treating Alzheimer's Disease and Other Dementias M. Catarina Silva, David C. Butler, Sally Temple, and Steve J. Haggarty
SECTION 8: PEDIATRIC PSYCHIATRIC DISORDERS Section Editor: Joseph D. Buxbaum
60. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders Magdalena Janecka, Artemis Briasouli, Vahe Khachadourian, and Abraham Reichenberg
61. Genetics of Pediatric-Onset Psychiatric Disorders Tess Levy and Joseph D. Buxbaum
62. Neuroimaging in Pediatric Psychiatric Disorders Timothy P.L. Roberts and Luke Bloy
63. Neurobiology of Autism Spectrum Disorders and Intellectual Disability: Animal and Human Studies Alexandra Massa, Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick R, Hof, and Alexander Kolevzon
64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies Tess Levy and Joseph D. Buxbaum
65. Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Animal and Human Studies Christopher Pittenger
66. Neurobiology of Eating Disorders: Animal and Human Studies Thomas Hildebrandt and Annabel Susanin
67. Current Treatments for Pediatric Psychiatric Disorders Paige M. Siper, M. Pilar Trelles, Yael Kufert, and Dorothy E. Grice
68. Novel Approaches for Treating Pediatric Psychiatric Disorders Niki P. Sabetfakhri and Edwin H. Cook, Jr.
SECTION 9: FUTURE DIRECTIONS OF PSYCHIATRY Section Editor: Dennis S. Charney
69. The Present and Future of Psychiatric Diagnoses Steven E. Hyman
70. The NIMH Research Domain Criteria Project: Toward Precision Medicine in Psychiatry Bruce N. Cuthbert
71. Computational Psychiatry and the Bayesian Brain Karl J. Friston and Xiaosi Gu
72. Digital Assessments of Psychiatric Disorders Rachel E. Quist, Sukanya Bhattacharya, Sarah M. Chacko, and Nicholas C. Jacobson
73. Digital Therapies of Psychiatric Disorders: Focus on Depression Symptoms Bruno Biagianti, Mor Nahum, Neta Yitzhak, and Sofia Vinogradov
74. Psychedelic Drugs as Treatment Agents Rachel Yehuda, Lauren A. Lepow, Philip A. Bonnano, Tamar Glatman Zaretsky, Josimar Hernandez Antonio, and Kathleen M. Jagodnik
75. Psychiatry's Past Challenges and Future Opportunities Ryan E. Lawrence and Jeffrey A. Lieberman
ISBN: 9780197640654
ISBN-10: 0197640656
Published: 3rd January 2025
Format: Hardcover
Language: English
Number of Pages: 1104
Audience: Professional and Scholarly
Publisher: Oxford University Press USA
Country of Publication: GB
Edition Number: 6
Edition Type: Revised
Dimensions (cm): 28.2 x 22.3 x 5.3
Weight (kg): 3.31
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