Preface to the fourth edition 6
Preface to the first edition 6
Glossary 7
Normal values 8
About the companion website 9
Part 1 Basic physiology and practice
1 Haemopoiesis: physiology and pathology 10
2 Normal blood cells I: red cells 14
3 Normal blood cells II: granulocytes, monocytes and the reticuloendothelial system 18
4 Normal blood cells III: lymphocytes 20
5 Lymph nodes, the lymphatic system and the spleen 23
6 Clinical assessment 24
7 Laboratory assessment 26
Part 2 Red cell disorders
8 General aspects of anaemia 30
9 Iron I: physiology and deficiency 33
10 Iron II: overload and sideroblastic anaemia 36
11 Megaloblastic anaemia I: vitamin B 12 (B 12) and folate deficiency – biochemical basis, causes 38
12 Megaloblastic anaemia II: clinical features, treatment and other macrocytic anaemias 40
13 Haemolytic anaemias I: general 42
14 Haemolytic anaemias II: inherited membrane and enzyme defects 44
15 Haemolytic anaemias III: acquired 46
16 Haemolytic anaemias IV: genetic defects of haemoglobin – thalassaemia 48
17 Haemolytic anaemias V: genetic defects of haemoglobin – sickle cell disease 52
Part 3 Benign disorders of white cells
18 Benign disorders of white cells I: granulocytes, monocytes, macrophages 54
19 Benign disorders of white cells II: lymphocytes, lymph nodes, spleen, HIV 56
Part 4 Haematological malignancies
20 Introduction to Haematological malignancy: basic mechanisms 58
21 General aspects of treatment 61
22 Acute leukaemia I: classification and diagnosis 64
23 Acute leukaemia II: treatment and prognosis 68
24 Chronic Myeloid Leukaemia (BCR-ABL1 positive) 70
25 Myelodysplasia (myelodysplastic syndromes) 72
26 Myeloproliferative disorders I: introduction 74
27 Myeloproliferative disorders II: polycythaemia rubra vera 76
28 Myeloproliferative disorders III: essential thrombocythaemia, primary myelofibrosis and systemic mastocytosis 78
29 Chronic lymphocytic leukaemia 80
30 Multiple myeloma and plasma cell disorders 83
31 Lymphoma I: introduction 86
32 Lymphoma II: Hodgkin lymphoma 88
33 Lymphoma III: non-Hodgkin lymphoma – aetiology and classification 90
34 Lymphoma IV: clinical and laboratory features of more common subtypes 92
35 Lymphoma V: treatment and prognosis 94
Part 5 Treatment and procedures
36 Bone marrow failure 96
37 Haematological effects of drugs 98
38 Stem cell transplantation 100
Part 6 Haemostasis
39 Normal haemostasis I: vessel wall and platelets 102
40 Normal haemostasis II: coagulation factors and fibrinolysis 104
41 Disorders of haemostasis I: vessel wall and platelets 106
42 Disorders of haemostasis II: inherited disorders of coagulation 108
43 Disorders of haemostasis III: acquired disorders of coagulation 110
44 Thrombosis and anti-thrombotic therapy 112
45 Anticoagulation 115
Part 7 Haematological aspects of tropical disease
46 Haematological aspects of tropical diseases 118
47 Haematology of pregnancy and infancy 120
Part 8 Blood transfusion
48 Blood transfusion I 122
49 Blood transfusion II 124
Appendix: cluster of differentiation nomenclature system 127
Index 129
