Inducible Enzymes in the Inflammatory Response

By: Willoughby (Editor), Tomlinson (Editor)

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Hardcover | 1 December 1998

At a Glance

Hardcover
228 Pages

Dimensions(cm)
23.39 x 15.6 x 1.42

Hardcover

$156.18

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The inducible isoforms of the enzymes cyclooxygenase (COX 2), nitric oxide synthase (iNOS) & heme oxygenase 1 (HO-1) have generated great interest as possible therapeutic targets in inflammation. This book is the first publication to address the importance of all three enzymes & the consequences of their interactions to the inflammatory process. The book brings together overviews by leading researchers in the field of the current status of knowledge of COX, NOS & HO in inflammation. These overviews cover a series of new concepts in the mechanism of inflammation. Topics include: Inducible enzyme involvement in inflammatory processes including the role in vascular permeability, leukocyte migration, granuloma formation, angiogenesis, neuroinflammation & algesia. New findings from transgenic animal models are reviewed. Other chapters address the importance of these enzymes in inflammatory disease states including rheumatoid arthritis, atherosclerosis & multiple sclerosis. The possibility of selective inhibitors or inducers of COX, NOS & HO, & their use in the clinic is discussed.

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List of contributors
Preface
Overview of COX-2 in inflammation: from the biology to the clinic	p. 1
Inducible nitric oxide synthase and inflammation	p. 31
Overview of HO-1 in inflammatory pathologies	p. 55
Inducible enzymes in the pathogenesis of rheumatoid arthritis	p. 93
iNOS and COX-2 in atherosclerosis	p. 109
The role of the inducible enzymes cyclooxygenase-2, nitric oxide synthase and heme oxygenase in angiogenesis of inflammation	p. 125
Role of the inducible forms of cyclooxygenase and nitric oxide synthase in inflammatory pain	p. 149
Neuroinflammation	p. 169
Inducible enzymes in inflammation: advances, interactions and conflicts	p. 187
Index	p. 207
Table of Contents provided by Blackwell. All Rights Reserved.

Inducible Enzymes in the Inflammatory Response

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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7th Edition

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