| Contributors | |
| Preface | |
| Dermal Toxicity | |
| Pseudo-Epidermis: An In Vitro Surrogate for the Study of Cutaneous Sulfur Mustard Toxicity | p. 3 |
| Refinement of an Endpoint for Measuring Skin Decontaminant Efficacy | p. 21 |
| An In Vitro Model for Skin Reconstruction | p. 27 |
| Critique of Cell Culture Methods in Skin Permeability Assessment | p. 37 |
| The Local Lymph Node Assay and Other Approaches to the Evaluation of Skin Sensitizing Potential | p. 49 |
| The Alternative to Animals for Assessing Topical Irritants Is Humans | p. 55 |
| Hexose Monophosphate Shunt Activity in Human Epidermal Keratinocytes Exposed to Sulfur Mustard | p. 59 |
| What Is Irritant Dermatitis? A Biological Approach | p. 65 |
| Skin[superscript 2]: An In Vitro Tissue Model for Assessment of Cutaneous Safety and Efficacy Needs | p. 89 |
| Biochemical and Flow Cytometric Studies of the Mechanism of Action of Sulfur Mustard Using Human Cells In Culture | p. 99 |
| A Multiphase Screen for the Evaluation of Topical Skin Protectants Against Chemical Warfare Agents | p. 103 |
| Developmental/Reproductive Toxicity | |
| Induction of Low-Molecular-Weight Heat-Shock Proteins in Drosophila and Human Embryonic Lineage Cells After Teratogen Exposure | p. 111 |
| Using Invariants of Swimming Motion in Biotoxicity Testing via Computerized Microscopy | p. 125 |
| Computation of Developmental Toxicity Potential by QSTR Models in the TOPKAT Program | p. 159 |
| Activity Profiles of Developmental Toxicity | p. 169 |
| Screening of Populations of Women at Risk for Reproductive Failure Using Cultured Rodent Embryos | p. 175 |
| Continued Evaluation and Application of a Bioluminescent Bacterial Genotoxicity Test | p. 181 |
| Immunotoxicity | |
| Cytokine Gene Expression and Allergic Contact Dermatitis | p. 193 |
| Strategies for Developing Alternative Methods to Assess Contact Allergens | p. 199 |
| Neurotoxicity | |
| Astrocytes as Target Site for Neurotoxicity | p. 209 |
| Altered Angiotensin-Induced Drinking as a Noninvasive Behavioral Biomarker of Neonatal Glutamic Acid Neurotoxicity in the Rat | p. 223 |
| Cell Cultures for Screening of Antiesterase Compounds | p. 229 |
| Mechanistic Neurotoxicity Studies Using PC12 Cells | p. 235 |
| MDCK: An Epithelial Cell Line Model of the Blood-Brain Barrier and Its Response to Cholinesterase Inhibitors | p. 243 |
| Oral/Dermal/Ocular Validation | |
| The Blood-Perfused Pig Ear: A Potential In Vitro Alternative for Dermal Permeation and Toxicity Studies | p. 251 |
| Bovine Corneal Opacity and Permeability Test Validation as an Alternative to the Draize Eye Irritation Assay | p. 261 |
| Metabolism of Humans and Animals Compared by Organ Cultures | p. 269 |
| Sulfur Mustard-Increased Proteolysis in Cultured Human Cells | p. 277 |
| Evaluation of Two In Vitro Human Skin Equivalents (Epiderm and Skin[superscript 2] Model ZK1300) for Assessing the Skin Irritation Potential of Personal Care Products and Chemicals | p. 285 |
| Strategies of Applications of In Vitro Methods to the Development of Pharmaceuticals and Devices | p. 293 |
| A Modular Approach to Validation - A Work in Progress | p. 303 |
| Evaluation of the CORROSITEX Method to Determine the Corrosivity Potential of Surfactants, Surfactant-Based Formulations, Chemicals, and Mixtures | p. 309 |
| Comparison Study of In Vitro and In Vivo Results on Textile Fabric Extracts for Assessing Dermal Irritancy Potential to Industrial Workers | p. 331 |
| Validation Issues for Alternatives Testing | p. 339 |
| Intra- and Interlaboratory Reproducibility of EpiDerm, an In Vitro Model for Dermal Irritancy Testing | p. 347 |
| Primary Human Hepatocytes as an In Vitro Toxicology System | p. 359 |
| Review of the Up-and-Down Method for Acute Toxicity Determination | p. 369 |
| Skin Partitions as a Screen for Dermal Permeability | p. 375 |
| Reduction of Animal Utilization in Dermal Toxicologic Studies | p. 381 |
| Computerized In Vitro Test for Chemical Toxicity Based on Tetrahymena Swimming Patterns | p. 387 |
| Renal Alterations Following Sublethal Mercury Toxicity: A Fish Model for Aquatic Environmental Contamination | p. 399 |
| A Nonlethal, Anesthetized Canine Model Used to Reduce the Number of Animals Required to Evaluate the Effectiveness of Pretreatment Compounds Challenged with Toxic Concentrations of Cyanide | p. 403 |
| Confocal Microscopy and Calcium Images of Keratinocytes Exposed to Sulfur Mustard | p. 409 |
| Inherited and Acquired Enzyme Defects in Multiple Chemical Sensitivity | p. 417 |
| An In Vitro Method for Detecting Toxicants by Changes in the Pattern of Polarized Light Scattered from Bacteria | p. 427 |
| Attaining a Rational Refinement and Reduction in the Use of Live Animals: Studies on Cyanide Toxicity | p. 433 |
| Integration of Alternative Tests into a Toxicology Research Program | p. 437 |
| Index | p. 445 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
