Contributors ix
Preface xiii
Acknowledgments xv
Important Notice xvii
List of Abbreviations xix
Section I General Principles of Antimicrobial Therapy 1
1 Antimicrobial Drug Action and Interaction: An Introduction 3
John F. Prescott
2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 13
Joseph E. Rubin and Peter Damborg
3 Antimicrobial Resistance and Its Epidemiology 29
Marisa Haenni and Patrick Boerlin
4 Pharmacokinetics of Antimicrobials 51
Patricia M. Dowling
5 Pharmacodynamics of Antimicrobials 81
Andrew P. Woodward and Ted Whittem Copyrighted Material
6 Principles of Antimicrobial Drug Selection and Use 109
J. Scott Weese and Patricia M. Dowling
Section II Classes of Antimicrobial Agents 119
7 Beta-lactam Antibiotics: Penam Penicillins 121
Laura Y. Hardefeldt and John F. Prescott
8 Beta-lactam Antibiotics: Cephalosporins 143
Laura Y. Hardefeldt and John F. Prescott
9 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 169
John F. Prescott and Laura Y. Hardefeldt
10 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 187
Patricia M. Dowling
11 Lincosamides, Pleuromutilins, and Streptogramins 203
Grazieli Maboni and Leticia Trevisan Gressler
12 Macrolides, Azalides, and Ketolides 223
John F. Prescott and Keith E. Baptiste
13 Aminoglycosides and Aminocyclitols 249
Patricia M. Dowling
14 Tetracyclines 273
Ronan J. J. Chapuis and Joe S. Smith
15 Chloramphenicol, Thiamphenicol, and Florfenicol 291
Patricia M. Dowling and Helene Larde
16 Sulfonamides, Diaminopyrimidines, and Their Combinations 305
Jennifer M. Reinhart and John F. Prescott
17 Fluoroquinolones 325
Patricia M. Dowling
18 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 345
Patricia M. Dowling and Keith E. Baptiste
19 Antifungal Chemotherapy 371
Keith E. Baptiste
Section III Antimicrobial Stewardship 401
20 General Concepts in Antimicrobial Stewardship 403
Laura Y. Hardefeldt, J. Scott Weese, and Stephen W. Page
21 Global Aspects of One Health Antimicrobial Stewardship 425
Jeffrey T. LeJeune, Mark E. Caudell, Suzanne N. Eckford, and Stephen W. Page
22 Antimicrobial Stewardship in Companion Animals 445
Peter Damborg, J. Scott Weese, and John F. Prescott
23 Antimicrobial Stewardship in Food-producing Animals 459
David C. Speksnijder, Stephen W. Page, Jaap A. Wagenaar, and John F. Prescott
24 Antimicrobial Prophylaxis, Metaphylaxis, and the Treatment of Immunocompromised Patients 487
Diego E. Gomez and J. Scott Weese
25 Regulation of Antimicrobial Use in Animals 513
Alan Chicoine and Keith E. Baptiste
26 Antimicrobial Drug Residues in Foods of Animal Origin 527
Joe S. Smith and Patricia M. Dowling
Section IV Antimicrobial Therapy in Selected Animal Species 545
27 Antimicrobial Drug Use in Horses 547
Keith E. Baptiste
28 Antimicrobial Therapy in Dogs and Cats 577
Jane E. Sykes and Peter Damborg
29 Antimicrobial Therapy in Beef Cattle 611
Michael D. Apley, Brian V. Lubbers, and Nora D. Schrag
30 Antimicrobial Therapy in Dairy Cattle 635
Sarah Wagner and Sarah Depenbrock
31 Antimicrobial Therapy in Sheep and Goats 655
Joe S. Smith and Amanda J. Kreuder
32 Antimicrobial Therapy in New World Camelids 671
Joe S. Smith
33 Antimicrobial Therapy in Swine 685
Ken Steen Pedersen
34 Antimicrobial Therapy in Poultry 697
Jenny A. Nicholds, David French, Daniel Parker, and Peter O’Kane
35 Antimicrobial Therapy in Companion Birds 721
Marike Visser
36 Antimicrobial Therapy in Rabbits, Rodents, and Ferrets 735
Colette L. Wheler and Patricia M. Dowling
37 Antimicrobial Therapy in Reptiles 767
J. Scott Weese
38 Antimicrobial Therapy in Zoo and Wildlife Species 791
Ellen Wiedner and Robert P. Hunter
39 Antimicrobial Therapy in Aquaculture 803
Patrick Whittaker, Timothy S. Kniffen, and Simon Otto
40 Antimicrobial Therapy in Honey Bees 819
Elemir Simko, Sarah Wood, and Ivanna V. Kozii
Index 831
