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Antisense Research and Applications

By: Bernard Lebleu, Stanley T. Crooke

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Hardcover | 27 May 1993 | Edition Number 1

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Hardcover
624 Pages

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18.6 x 26.1 x 4.4

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Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications.
In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs.
This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.

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Non-Fiction Science Chemistry Organic Chemistry Medicine Other Branches of Medicine Pharmacology Biology, Life Sciences Biochemistry Molecular Biology Engineering & Technology Biochemical Engineering

Biotechnology Clinical & Internal Medicine Diseases & Disorders Oncology Pre-Clinical Medicine & Basic Sciences Physiology

Basic Principles of Antisense Therapeutics	p. 1
Antisense Medicinal Chemistry	p. 51
In Vitro Cellular Uptake, Distribution, and Metabolism of Oligonucleotides	p. 103
Pharmacokinetic Properties of Phosphorothioates in Animals - Absorption, Distribution, Metabolism and Elimination	p. 141
Toxicity of Oligodeoxynucleotide Therapeutic Agents	p. 169
Pharmacokinetic Properties of Phosphorothioate Oligonucleotides in Humans	p. 217
Safety and Tolerance of Phosphorothioates in Humans	p. 233
Immune Stimulation by Oligonucleotides	p. 243
Pharmacological Inhibition of Dopaminergic and Other Neurotransmitter Receptors Using Antisense Oligodeoxynucleotides	p. 263
Pharmacological Effects of Antisense Oligonucleotide Inhibition of Immediate-Early Response Genes in the CNS	p. 309
Inhibition of G Proteins by Antisense Drugs	p. 341
Use of Antisense Oligonucleotides to Modify Inflammatory Processes	p. 371
Antisense Oligonucleotides and Their Anticancer Activities	p. 395
Pharmacological Activity of Antisense Oligonucleotides in Animal Models of Disease	p. 427
Clincial Antiviral Activities	p. 445
Antisense Oligonucleotides to Protein Kinase C-[alpha] and C-raf Kinase: Rationale and Clinical Experience in Patients with Solid Tumors	p. 463
Nucleic Acid Therapeutics for Human Leukemia: Development and Early Clinical Experience with Oligodeoxynucleotides Directed at c-myb	p. 477
Properties of ISIS 2302, an Inhibitor of Intercellular Adhesion Molecule-1, Humans	p. 499
Pharmacokinetics and Bioavailability of Antisense Oligonucleotides Following Oral and Colorectal Administrations in Experimental Animals	p. 525
Antisense Properties of Peptide Nucleic Acid	p. 545
Triple Helix Strategies and Progress	p. 561
Subject Index	p. 611
Table of Contents provided by Blackwell. All Rights Reserved.

Antisense Research and Applications

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Hardcover

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