Acknowledgements | p. xi |
Preface | p. xiii |
General Considerations | |
Methods of Drug Administration | p. 1 |
Water medication | p. 1 |
In-feed medication | p. 6 |
Gavage | p. 12 |
Injection | p. 12 |
Topical application | p. 15 |
Safety of Fish Medicines | p. 16 |
Aspects of safety | p. 16 |
Safety to the target species | p. 17 |
Safety to the operator | p. 18 |
Safety to the consumer | p. 19 |
Safety to the environment | p. 22 |
The Law | p. 26 |
The aims of legislation | p. 26 |
Labelling | p. 27 |
Drug usage outwith MA provisions | p. 28 |
Legal control of in-feed medication | p. 30 |
Environmental safety legislation | p. 31 |
Consumer safety - Regulation 2377/90/EEC | p. 34 |
Market authorizations | p. 38 |
Future developments | p. 50 |
Antibacterial Drugs | |
Comparative Aspects | p. 55 |
Introduction | p. 55 |
Selection of antibacterial drugs | p. 56 |
Environmental safety | p. 58 |
Bacterial resistance | p. 61 |
Tetracyclines | p. 64 |
Group characteristics | p. 64 |
Uses of oxytetracycline | p. 65 |
Pharmacokinetics of oxytetracycline | p. 66 |
Pharmacodynamics of oxytetracycline | p. 76 |
Oxytetracycline in the environment | p. 79 |
Other tetracyclines | p. 81 |
Penicillins | p. 83 |
Group characteristics | p. 83 |
Uses | p. 83 |
Dose rates | p. 84 |
Pharmacokinetics | p. 85 |
Macrolides | p. 87 |
Group characteristics | p. 87 |
Pharmacokinetics of erythromycin | p. 87 |
Toxicology of erythromycin | p. 90 |
Control of bacterial kidney disease | p. 91 |
Other macrolides | p. 94 |
Sulfonamides | p. 95 |
Group characteristics | p. 95 |
Pharmacokinetics | p. 96 |
Potentiated sulfonamides | p. 106 |
Group characteristics | p. 106 |
Pharmacokinetics | p. 112 |
Quinolones and Fluoroquinolones | p. 117 |
Group characteristics | p. 117 |
Nalidixic acid | p. 119 |
Oxolinic acid | p. 123 |
Piromidic acid | p. 130 |
Flumequine | p. 131 |
Other fluoroquinolones | p. 137 |
Other Systemic Antibacterial Agents | p. 143 |
Nitrofurans | p. 143 |
Chloramphenicol | p. 148 |
Florfenicol | p. 151 |
Other Chemotherapeutic Agents | |
Systemic Anti-protozoal Agents | p. 155 |
Fumagillin | p. 155 |
Nitroimidazoles | p. 159 |
Externally applied antimicrobial agents | p. 161 |
Formalin | p. 161 |
Malachite green | p. 164 |
Leteux-Meyer mixture | p. 171 |
Chloramine-T | p. 172 |
Copper sulfate | p. 176 |
Ectoparasiticides | p. 180 |
Metazoan ectoparasites | p. 180 |
Organo-phosphorus compounds | p. 180 |
Hydrogen peroxide | p. 188 |
Ivermectin | p. 191 |
Cypermethrin | p. 195 |
Benzyl-ureas | p. 197 |
Anthelmintics | p. 200 |
Worm parasites of fish | p. 200 |
Flukicides | p. 201 |
Tapeworm and roundworm treatments | p. 204 |
Pharmacodynamic Agents | |
Anaesthetics | p. 206 |
General considerations | p. 206 |
MS-222 | p. 209 |
Benzocaine | p. 211 |
Other anaesthetic agents | p. 214 |
Hypnotics and sedatives | p. 217 |
Breeding induction agents | p. 220 |
Reproductive physiology | p. 220 |
Drugs used in breeding induction | p. 224 |
Procedures for individual species | p. 230 |
Sex control | p. 241 |
The objectives of sex control | p. 241 |
Induction of triploidy | p. 242 |
Medicinal production of all-female populations | p. 243 |
Sex control in tilapia | p. 246 |
Production of sterile carp | p. 248 |
Induction of sex change in hermaphrodite species | p. 249 |
Safety Aspects | p. 249 |
Immuno-stimulants | p. 251 |
Immuno-modulation | p. 251 |
Glucans | p. 254 |
Other immuno-stimulants | p. 256 |
Vaccines | p. 260 |
Evaluation | p. 260 |
Routes of administration | p. 266 |
Available vaccines | p. 271 |
Osmoregulators | p. 276 |
Physiological osmo-regulation | p. 276 |
Medicinal osmo-regulation | p. 277 |
Disinfectants | p. 281 |
Uses of disinfectants | p. 281 |
Chemical disinfectants | p. 282 |
Appendices | |
Trade marks of products specifically formulated for use in fish | p. 289 |
Linnean and English names of cultured species of finfish | p. 293 |
Glossary | p. 297 |
Index | p. 299 |
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