Contributors | p. xiii |
Preface | p. xvii |
Experimental Autoimmune Encephalomyelitis in the Mouse | |
Introduction: Murine Experimental Autoimmune Encephalomyelitis as a Model for T-Cell-Mediated Demyelinating Disease of the Central Nervous System | p. 1 |
Models of EAE in the Mouse | p. 2 |
Evaluation of the Disease | p. 6 |
Summary | p. 12 |
References | p. 13 |
Rat Experimental Autoimmune Encephalomyelitis | |
History and Introduction | p. 15 |
Animals and Housing | p. 16 |
Genetic Background | p. 16 |
Disease Induction | p. 17 |
Quantitation | p. 19 |
Expert Experience | p. 20 |
References | p. 21 |
Theiler's Virus-Induced Demyelinating Disease | |
History and Relevance of the Model | p. 23 |
The Animals | p. 25 |
Genetics of Susceptibility or Resistance | p. 25 |
The Disease | p. 27 |
Lessons | p. 36 |
References | p. 36 |
Experimental Autoimmune Neuritis | |
Introduction | p. 39 |
Isolation and Composition of Peripheral Nerve Myelin | p. 40 |
Basic Features of EAN | p. 43 |
Immunopathogenesis of EAN--A Model for Therapeutic Studies | p. 52 |
References | p. 53 |
Experimental Autoimmune Uveoretinitis--Rat and Mouse | |
Introduction | p. 57 |
Rat EAU | p. 60 |
Mouse EAU | p. 68 |
Expert Experience | p. 75 |
Lessons | p. 77 |
References | p. 77 |
Experimental Autoimmune Myasthenia Gravis | |
Introduction | p. 83 |
Immunization against Purified Electric Organ AChR | p. 85 |
Assessment of EAMG and the Safety Factor | p. 89 |
Immunization against Purified Mammalian AChR | p. 90 |
Immunization without Adjuvant | p. 90 |
Genetics of EAMG in Rats and Mice | p. 92 |
T- and B-Cell Epitopes in EAMG | p. 95 |
Immunization against Denatured AChR Subunits, Recombinant or Synthetic Peptides | p. 97 |
Resistance to EAMG | p. 97 |
Alternative Models | p. 99 |
Use of EAMG for Therapeutic Studies | p. 101 |
Relation to Human Disease | p. 101 |
Conclusions | p. 101 |
Lambert-Eaton Myasthenic Syndrome | p. 103 |
References | p. 103 |
The Obese Strain with Spontaneous Autoimmune Thyroiditis as a Model for Hashimoto Disease | |
Introduction | p. 107 |
History and Development of the OS | p. 108 |
Clinical Symptoms and Pathohistology | p. 109 |
Immunological Parameters | p. 110 |
Breeding and Management of OS Chickens | p. 116 |
Immunogenetics | p. 118 |
Comparison of SAT and EAT | p. 119 |
Use of the OS for the Development of New Therapeutic Strategies | p. 120 |
Conclusions | p. 121 |
References | p. 121 |
Experimental Autoimmune Thyroiditis in the Mouse and Rat | |
Experimental Autoimmune Thyroiditis in the Mouse | p. 123 |
Experimental Autoimmune Thyroiditis in the Rat | p. 133 |
Lessons | p. 138 |
References | p. 142 |
The NOD Mouse: A Model for Autoimmune Insulin-Dependent Diabetes | |
History of the Model | p. 147 |
The Animal | p. 148 |
The Disease | p. 149 |
Genetics | p. 154 |
Treatment and Prevention | p. 156 |
Notes for the Beginner | p. 158 |
What the Model Has Taught Us about Human IDDM? | p. 159 |
References | p. 159 |
The BB Rat Models of IDDM | |
History | p. 163 |
Animals | p. 163 |
Genetics | p. 166 |
The Disease | p. 167 |
Quantitation | p. 171 |
Resistance | p. 171 |
Expert Experience | p. 172 |
Lessons | p. 172 |
References | p. 173 |
Experimental Myocarditis | |
The Models | p. 175 |
Production of Virus-Induced Myocarditis | p. 177 |
Production of Myosin-Induced Myocarditis | p. 181 |
Evaluation | p. 182 |
References | p. 188 |
Experimental Hepatitis | |
History of Experimental Autoimmune Hepatitis | p. 191 |
Animals | p. 193 |
Genetic Background | p. 193 |
Induction and Time Course | p. 193 |
Quantitation | p. 196 |
Resistance | p. 197 |
Expert Experience | p. 197 |
Lessons | p. 198 |
References | p. 198 |
Adjuvant Arthritis | |
History of the Model | p. 201 |
Animals | p. 202 |
Induction of the Disease | p. 203 |
Course of the Disease | p. 208 |
Quantitation of the Disease | p. 209 |
Resistance to the Disease | p. 211 |
Expert Experience | p. 212 |
Lessons | p. 213 |
References | p. 214 |
Murine Models of Spontaneous Systemic Lupus Erythematosus | |
Introduction | p. 217 |
(NZB X NZW) F[subscript 1] | p. 218 |
MRL-lpr/lpr | p. 225 |
Quantitation | p. 236 |
Conclusions | p. 240 |
References | p. 240 |
Experimental Systemic Lupus Erythematosus: Role of the Idiotypic Network | |
History of the Model | p. 245 |
Animals and Housing | p. 247 |
Genetic Background | p. 248 |
Disease Induction | p. 249 |
Course of the Disease | p. 250 |
Resistance to the Disease | p. 251 |
Manipulation of the Disease | p. 252 |
Lessons | p. 253 |
References | p. 253 |
Autoimmune Vasculitis | |
Introduction and History of the Model | p. 257 |
Animals | p. 257 |
Genetic Background | p. 258 |
Disease Induction | p. 258 |
Lesion and Course of the Disease | p. 259 |
Autoimmune Myositis | p. 264 |
References | p. 264 |
Testicular and Ovarian Autoimmune Diseases | |
Introduction | p. 267 |
Experimental Autoimmune Orchitis | p. 268 |
Experimental Autoimmune Oophoritis | p. 275 |
Autoimmune Oophoritis Following Manipulation of the Normal Murine Immune System | p. 280 |
Summary and Conclusions | p. 287 |
References | p. 288 |
Allogeneic Diseases | |
Chronic Graft-versus-Host Disease | p. 291 |
Host-versus-Graft Disease | p. 295 |
Lessons | p. 299 |
References | p. 300 |
Assessment of Discomfort in Laboratory Animals | |
Introduction | p. 303 |
Arguments for Assessing Discomfort | p. 304 |
Stress and Discomfort | p. 305 |
Assessment of Discomfort | p. 311 |
An Example of Assessing Discomfort in Practice | p. 314 |
Possibilities for Diminishing Discomfort | p. 316 |
References | p. 318 |
Index | p. 321 |
Table of Contents provided by Syndetics. All Rights Reserved. |