Bioprocessing, Bioengineering and Process Chemistry in the Biopharmaceutical Industry

The exponential growth of novel complex biotherapeutic modalities in the modern era demonstrated to bring forth the potential to revolutionize healthcare industry, offering innovative approaches to treat, prevent, and in some providential cases, cure the disease. Discovery and development of these novel medicines requires convergence of many scientific and engineering disciplines which believed to be essential, and Bioprocessing, Bioengineering and Process Chemistry in the Biopharmaceutical Industry: Using Chemistry and Bioengineering to Improve the Performance of Biologics captures the state of the art for many of these new modalities. This book outlines how advances in synthetic biology, DNA synthesis, production of protein therapeutics, and bioinformatics, have led to the commercialization of new medicines beyond monoclonal antibodies, including multispecific antibodies, antibody drug conjugates, fusion proteins, CAR-T and CRISPR technologies and applications, mRNA vaccines and more. Enabling to bring these life-changing medicines into the hands of the needy patients requires regulatory submissions to authorities across the globe, as well as streamlined production across manufacturing networks deemed necessary and are outlined in dedicated chapters. This book will be of significant interest for many disciplines engaged jointly as teams in delivering these medicines: bioprocess engineers, biologists, chemists, bioengineers, genetic engineers, healthcare professionals, regulatory bodies, among pharmaceutical industry professionals as well as in academic circles.