Preface | p. x |
The Chemical Constituents of Cannabis sativa and the Endocannabinoid System | p. 1 |
Pharmacology and Medicinal Chemistry of THC | p. 8 |
Pharmacology of THC | p. 9 |
Medicinal Chemistry | p. 16 |
The Pharmacology and Therapeutic Potential of Cannabidiol | p. 32 |
Receptor Interactions of Cannabidiol | p. 35 |
Effects of CBD on Central and Peripheral Neurotransmission | p. 42 |
Fate of Anandamide and Palmitoylethanolamide | p. 43 |
Anxiolytic and Antipsychotic Effects | p. 44 |
Anticonvulsant Effects of CBD | p. 46 |
Neuroprotective Effect of CBD | p. 53 |
Effects of CBD on the Production of Mediators of Inflammation and Immune Responses | p. 54 |
Effects of CBD on Cancer Cell Proliferation | p. 59 |
Effects of CBD on Cytochrome P450 (CYP) Isozymes | p. 60 |
Effects of CBD on Membrane Fluidity and Stability | p. 61 |
Other Effects of CBD | p. 62 |
Interactions between CBD and [Delta superscript 9]-THC | p. 64 |
Structure-Activity Relationships | p. 65 |
Cannabinoid Receptors and Signal Transduction | p. 84 |
CB[subscript 1] Receptor and Signal Transduction Pathways | p. 84 |
CB[subscript 2] Receptor and Signal Transduction Pathways | p. 87 |
Endothelial Anandamide Receptor: Pharmacology and Signal Transduction Pathways | p. 88 |
Mechanism of Receptor-Mediated G Protein Coupling | p. 88 |
Endocannabinoids | p. 98 |
Discovery of the Endocannabinoids | p. 99 |
Quantitative Analysis of Endocannabinoids in Mammals | p. 100 |
Biosynthesis, Action and Inactivation of Endocannabinoids | p. 101 |
Possible Physiological and Pathological Functions of Endocannabinoids in the CNS--An Overview | p. 113 |
Endocannabinoids: Relax, Eat, Rest, Forget and Protect | p. 118 |
Chemistry and Structure Activity Relationships for Tetrahydrocannabinols and Endocannabinoids | p. 131 |
Endocannabinoids | p. 138 |
Pyrazole Based Antagonists | p. 141 |
Cannabinoids and Medicine: Eating Disorders, Nausea and Emesis | p. 147 |
Endocannabinoids and the Physiological Regulation of Appetite and Body Weight | p. 147 |
Disorders of Appetite and Body Weight | p. 150 |
Obesity | p. 150 |
Cachexia, Anorexia and Malnutrition in Disease | p. 152 |
Nausea and Emesis | p. 155 |
Cannabinoids and Medicine II: The Role of Cannabinoids in Multiple Sclerosis and Neuronal Damage | p. 161 |
Multiple Sclerosis | p. 162 |
Head Injury and Stroke | p. 167 |
Glaucoma | p. 169 |
Parkinson's Disease | p. 170 |
Huntington's Disease | p. 171 |
Motor Neuron Diseases | p. 172 |
Alzheimer's Disease | p. 173 |
Endocannabinoids and Related Fatty Acid Derivatives in Pain Modulation: Behavioral, Neurophysiological and Neuroanatomical perspectives on Cannabinoid Antinociception | p. 181 |
Functional Significance of a Cannabinoid Transmitter System | p. 181 |
Subtypes of Cannabinoid Receptors | p. 182 |
Endocannabinoids | p. 182 |
Cannabinoid Receptor Pharmacology | p. 183 |
Antinociceptive Effects of Cannabinoids | p. 183 |
Cannabinoid-Induced Suppression of Nociceptive Transmission | p. 183 |
Spinal and Peripheral Cannabinoid Antinociceptive Mechanisms | p. 184 |
Evidence for Endocannabinoid Modulation of Nociception at the Supraspinal Level | p. 187 |
Role of Other Endocannabinoids and Related Fatty Acid Derivatives | p. 189 |
Localization of Cannabinoid Receptors and mRNA | p. 190 |
Cannabinoid Receptor Distribution on Central Terminals of Primary Afferents | p. 193 |
Endocannabinoids and Alcohol Drinking Behavior | p. 205 |
Endocannabinoids and Brain Reward Mechanisms | p. 205 |
Endocannabinoids As Regulators of Alcohol Preference | p. 206 |
Age-Dependence of Alcohol Preference and Endocannabinoid Signaling in Mice | p. 207 |
Endocannabinoids and Alcohol-Withdrawal | p. 209 |
A New Hypothesis | p. 209 |
Index | p. 213 |
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