Carbonic Anhydrases

Carbonic anhydrases are universal metalloenzymes, existing in humans and most organisms, that catalyze the quick interconversion of carbon dioxide and water to bicarbonate and protons. The regular discovery of novel isozymes belonging to different CA classes and new CA modulators, as well as continuous findings regarding known isoforms of pharmaceutical interest, continually revitalizes CAs as an evergreen pharmaceutical target, relevant to cancer, neurologic, metabolic, immunologic, infectious, microbial, and pain disorders among others.

Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target provides a detailed overview of CAs, spanning biochemical and structural features to pharmacology and drug-design, and also touching on the various biotechnological applications of these metalloenzymes. The book adopts a clear, step-by-step approach and introduction to this intricate and highly interdisciplinary field, first covering carbonic anhydrase classification (biochemistry and the structure of all CA classes), followed by their role as drug targets (pharmacology and drug design of carbonic anhydrase inhibitors and activators), and biotechnological applications of specific CA classes. A diverse range of chapters from international experts speak to carbonic anhydrase distribution, carbonic anhydrase families, human carbonic anhydrase, CA inhibitors and activators, CA zinc binders, zinc-bound nucleophile, and CA employed in treatment of glaucoma, epilepsy, obesity, neuropathic pain, arthritis, and infectious and fungal agents among other diseases and threats to human health.

• Provides a full overview of carbonic anhydrases' biochemical and structural features, pharmacology, drug-design, and biotechnological applications
• Features chapter contributions from international leaders in carbonic anhydrase-driven biochemical research and pharmacology
• Prepares active researchers (in academia and industry) and students to perform their own research in this intricate and highly interdisciplinary field