Cardiac Valve Allografts 1962-1987

Honorary guest lecture.- Evolution of the biological concept in cardiac surgery: A Pilgrim's Process.- Procurement and preservation techniques.- Allogeneic valve procurement in cardiac transplantation.- Antibiotic sterilisation in the preparation of homovital homograft valves: Is it necessary?.- Procurement and viability of cardiac valve allografts.- Cryobiology of tissues.- Cryopreservation of aortic valve homografts.- Factors affecting the viability of cryopreserved allograft heart valves.- Endothelial and fibroblast viability assays for tissue allografts.- Discussion.- Contributions for discussion: Problems of homograft procurement.- Heart valve procurement in Berlin.- Transplantation immunology of heart valve allografts.- Basic principles of transplantation immunology.- Cryopreserved and fresh valved aortic homograft conduits in a chronic sheep model: Haemodynamic, angiographic and histological comparisons.- Homograft valve calcification: Evidence for an immunological influence.- Pathology of human explanted aortic valve homografts: A comparative morphological study with porcine aortic valve expiants.- Antigenicity and fate of cellular components of heart valve allografts.- Immunohistopathology of cardiac valve allograft expiants.- Applications and limitations of histocompatibility in clinical cardiac valve allograft surgery.- Discussion.- Allograft surgery of the aortic root and the ascending aorta: Transplantation techniques.- The anatomy of the outflow tracts of the heart and of aortic and pulmonary allografts.- Selection of allograft valve size.- "Fresh" free-hand, non-viable allografts for aortic valve replacement: Operative techniques and 15-year results.- Modified techniques for subcoronary insertion of allografts.- Allograft aortic root replacement.- Extended aortic root replacement in 12 patients with complex left ventricular outflow tract obstruction.- Aortic root replacement with a cardiac allograft: The infected aortic root.- Indications and surgical technique of aortic valve replacement with the autologous pulmonary valve.- Reconstruction of the right ventricular outflow tract (RVOT) with allografts: Transplantation techniques.- The morphology of tricuspid atresia, pulmonary atresia and truncus arteriosus.- Population-based requirements for allograft valve surgery in children.- The pulmonary allograft for right ventricular outflow tract reconstruction.- Pulmonary valve allograft reconstruction of the right ventricular outflow tract.- Technique of inlay allografts into the RVOT to prevent pulmonary insufficiency.- Allografts in the treatment of absent pulmonary valve syndrome and complex tetralogy of Fallot.- Technique of allograft repair of tetralogy of Fallot with pulmonary atresia.- The use of aortic allografts in the primary repair of truncus arteriosus in early infancy and replacement of previous conduits.- Long-term results of antibiotic-treated (4 C) allograft valves and valved conduits.- Allografts in the Rastelli procedure: Techniques.- Allograft conduit for Fontan procedure.- Late results of homograft function used for right ventricular outflow obstruction.- Pulmonary autografts, viable and non-viable aortic allografts in the subcoronary position: A comparative study.- Long-term results of antibiotic-treated aortic allografts in subcoronary position.- Survival of aortic allografts containing living cells.- Intermediate and long-term results of cryopreserved allografts.- Short-term results after allograft transplantation in the pulmonary position following previous repair of tetralogy of Fallot.- Intermediate-term results of cryopreserved allograft and xenograft valved ventricle to pulmonary artery conduits.- Functional evaluation of allografts by non-invasive techniques.- Cryopreserved viable allograft aortic valves.- Short-term follow-up of cryopreserved allograft valves and valved conduits from the CryoLife clinical registry.- Discussion.- Contribution for discussion: A mathematical model of aortic valve vibration.- Honorary guest lecture.- 25 years' clinical experience of allograft surgery - A time for reflection.- Current concepts on the use of aortic and pulmonary allografts.- Panel discussion.- Summary.- Closing remarks.- Author index.