| In Memorium | |
| In Memory of Dr. Sidney Udenfriend | p. 1 |
| Dr. Sidney Udenfriend Memorial Lecture | |
| Molecular Genetics of Catecholamines: Key Molecules Bridging Basic Science with Clinical Science | p. 5 |
| Catecholamine Uptake, Storage, and Release | |
| Chromogranins / Current Concept | p. 19 |
| The Vesicular Monoamine Transporters (VMATs): Role In the Chemical Coding of Neuronal Transmission and Monoamine Storage In Amine-Handling Immune and Inflammatory Cells | p. 23 |
| Mutants and Variants of the Human Antidepressant-Sensitive Norepinephrine Transporter | p. 35 |
| D[subscript 2] Receptor-Mediated Regulation of Vesicular Dopamine Uptake | p. 39 |
| A Varicosity Ensemble Model of Sympathetic Neuromuscular Transmission | p. 43 |
| Single Sympathetic Varicosities and Their Receptor Clusters: Regulation of Transmitter Release and Cluster Formation | p. 47 |
| Enhancement of Noradrenergic Phenotype Expression in Transgenic Mice Overexpressing V-1, A Cytoplasmic Ankyrin Repeat Protein | p. 53 |
| Multiple Roles of Actin Cytoskeleton in Catecholamine Release from Chromaffin Cell | p. 57 |
| Interaction of Tyrosine Hydroxylase and 14-3-3 Proteins in PC12 Cells | p. 61 |
| Acetylcholinesterase Inhibitor Elicits Muscarinic Receptor-Mediated Cholinergic Transmission in the Rat Adrenal Medulla | p. 65 |
| Leptin Stimulates Catecholamine Synthesis Via Tyrosine Hydroxylase Phosphorylation-Dependent and -Independent Pathways in Cultured Bovine Adrenal Medullary Cells | p. 69 |
| Sympathetic Potentiation of Cyclic Adp-Ribose Formation in Rat Cardiac Myocytes | p. 73 |
| RAB3A Small G Protein and Its Regulators in Neurotransmitter Release and Synaptic Plasticity | p. 77 |
| Assessing Sympathetic Function From Dynamics of Norepinephrine Metabolism and False Transmitters | p. 81 |
| Adenylyl Cyclase: A Molecule of Diversity | p. 87 |
| L-Dopa Uptake and Decarboxylation in the Brain | p. 91 |
| Dopamine Synthesis From L-Tyrosine by Non-Dopaminergic Neurons in Co-Operation | p. 95 |
| Dopamine Neurons Are Not Affected by Expanded Polyglutamine Stretches in HD Gene Knock-in Mice | p. 99 |
| Catecholamine--Neuropeptide Interactions | p. 103 |
| The Noradrenergic Neuron, A Multipeptide Secretory Cell | p. 107 |
| Regulation of Catecholamine Biosynthetic Enzymes | |
| Transient Tyrosine Hydroxylase Expression in the Non-Catecholaminergic Neurons of Pre- and Postnatal Mice | p. 111 |
| Gdne-Induced Expression of Tyrosine Hydroxylase | p. 115 |
| Cell-Type Specific Gene Regulation of Tyrosine Hydroxylase in the Central Nervous System | p. 119 |
| Mechanisms of Tyrosine Hydroxylase Regulation with Age | p. 123 |
| Transcriptional Regulation of the Dopamine [beta]-Hydroxylase Gene | p. 127 |
| Identification of Active Site Amino Acid Residues of Phenylethanolamine N-Methyltransferase | p. 131 |
| Neural Mechanisms Regulating Phenylethanolamine N-MethylTransferase Gene Expression | p. 135 |
| Regulation of Tetrahydrobiopterin Biosynthesis: Catalytic Residues of Sepiapterin Reductase, the Terminal Enzyme of BH[subscript 4]-Biosynthesis | p. 139 |
| Gtp Cyclohydrolase I Gene Expression and Catecholamine Synthesis | p. 143 |
| In Vivo and in Vitro Functions of Two Types of MAO | p. 147 |
| Current Status of New MAO-A/B Inhibitor Development | p. 151 |
| Molecular Basis for the Substrate Specificity of Human Catecholamine Sulfotransferase, SulT1A3 | p. 155 |
| The Dopaminergic System | |
| Structural Insights Into D[subscript 1] Dopamine Receptor Phosphorylation and Desensitization | p. 159 |
| The Neurobiology of Dopamine Signaling | p. 163 |
| Mutant Mice Lacking Dopamine Receptor Genes | p. 165 |
| Interaction Between Glutamate and Monoamines: Modulation of Glutamatergic Neurotransmission By Dopamine D1 and 5-HT2A Receptors | p. 167 |
| Analysis of Dopamine D4 Receptor Function in Gene Knockout Mice: A Role In Cortical Excitability | p. 171 |
| Dopamine D2L Receptor Knockout Mouse Provides a Unique Model System for Studying the Functions of D2L and D2S | p. 175 |
| Neurobiological Features of Dopamine D2 Receptors: Distinct Functions of D2L and D2S in Vivo | p. 179 |
| Role of Presynaptic Dopamine D[subscript 2]-Like Receptors in Midbrain Dopaminergic System | p. 183 |
| Dopamine-Dependent Long-Term Potentiation Induced By 3-Nitropropionic Acid in Striatal Medium Spiny Neurons | p. 187 |
| Dopaminergic Regulation of Synaptic Plasticity of Striatal Cholinergic Interneurons | p. 191 |
| Role of Shp2 Tyrosine Phosphatase in Trophic Effects of Bdnf in Cultured Dopaminergic Neurons of Substantia Nigra | p. 195 |
| Heteromerization of Adenosine and Dopamine Receptor Subtypes: Relevance for Neuronal Integration In Normal and Pathological States | p. 199 |
| Developmental Neurobiology of Catecholaminergic Systems | |
| Neuronal Gene Regulation By the Neural - Restrictive Silencer (NRS): Is the Catecholaminergic System Excluded from Control By NRS? | p. 205 |
| Prenatal Lipopolysaccharide Alters Postnatal Dopamine in the Laboratory Rat | p. 209 |
| Transcriptional Cascades to Regulate Neuronal Differentiation By Mammalian Barh1 (MBH1) | p. 213 |
| Brain-Specific Migration and Protective Roles in Brain Damage of Microglia: A New Therapeutic Approach For Catecholamine Neuronal Disfunctions | p. 217 |
| Mechanisms Underlying Neuronal Death Induced By Activated Microglia | p. 221 |
| Adrenergic Control of Microglia | p. 225 |
| Dopa Is a Causal Factor for Glutamate Release and Delayed Neuron Death By Transient Ischemia in Striatum and Hippocampal CA1 of Conscious Rats | p. 229 |
| Stimulation of Neurotrophin Synthesis By 4-METHYL Catechol: An Approach to the Treatment of Neurodegeneration | p. 233 |
| Neurotoxic Factors Targeting the Dopaminergic System | p. 237 |
| Anti-Apoptotic Function of Propargylamines | p. 241 |
| Melatonin, Nitric Oxide Synthase and Oxidative Stress: Implications in Aging | p. 245 |
| Regulation of Cell Death by the BCL-2 Family of Proteins | p. 249 |
| G-Protein-Mediated Regulation of P/Q-Type Calcium Channels by [alpha subscript 2] and [beta] Adrenergic Receptors Exogenously Expressed in Xenopus Oocytes | p. 253 |
| [alpha subscript 1]-Adrenergic Receptors of MDCK-D[subscript 1] Cells Utilize Multiple Signalling Components | p. 257 |
| Differential Regulation of Myocardial Cell Apoptosis by [alpha]- and [beta]-Adrenergic Pathways | p. 261 |
| Behavioral and Histochemical Studies in Repeated Cerebral Ischemia in Rats | p. 265 |
| Structure and Function of Neuromelanin | p. 269 |
| Biosynthesis of Neuromelanin and Melanin: The Potential Involvement of Macrophage Inhibitory Factor and Dopachrome Tautomerase as Rescue Enzymes | p. 273 |
| Hypothalamo-Sympathetic Control of Cellular Immunity | p. 277 |
| Physiological Effects of Catecholamines | |
| Vasoactive Hormones and Regulation of the Hypothalamic-Pituitary-Adrenal Axis | p. 281 |
| [alpha subscript 1D]-Adrenergic Receptor Knockout Mice Display Impaired Vascular Contractile Response to Catecholamines | p. 285 |
| Cathecolaminergic Neurons in the Olfactory Bulb | p. 289 |
| Involvement of Ionotropic Glutamate Receptors and Nitric Oxide in Dopa-Induced Depressor Responses in the Nucleus Tractus Solitarii | p. 293 |
| Methodological Advances | |
| Efficient Gene Transfer to Neural Stem Cells by High Titer Retroviral Vectors | p. 297 |
| The Evolution of in Vivo Voltammetry and Microdialysis | p. 301 |
| Fast-Scan Cyclic Voltammetry in Freely-Moving Rats | p. 305 |
| Determination of Subnanomolar Concentrations of Dopamine and Norepinephrine in Nanovolume Samples Using an Automated Capillary Zone Electrophoresis with Laser Induced Fluorescence Detection | p. 309 |
| Catecholamines, Stress, and Behavior | |
| The Role of Angiotensin II AT[subscript 1] Receptors in the Sympathoadrenal Response to Stress | p. 313 |
| Differential Gene Expression of Tyrosine Hydroxylase in Rats Exposed Long-Term to Various Stressors | p. 317 |
| Dynamics of Transcriptional Events in Stress-Triggered Regulation of Adrenal Catecholamine Biosynthetic Enzymes | p. 321 |
| The Role of the Central Catecholamine System in the Organization of Neuronal and Neurohumoral Responses to Various Stressful Stimuli | p. 325 |
| Emotional Stress- and Catecholamine-Induced Molecular and Electrocardiographic Responses in the Heart | p. 329 |
| Stressor-Specific Activation of Catecholamine Systems in Humans | p. 333 |
| Brain Norepinephrine Systems and Anxiety | p. 337 |
| Monoamines and Fear-Related Behaviors | p. 341 |
| Dopaminergic Effects on Acquisition and Consolidation: A Microdialysis Study | p. 345 |
| The Locus Coeruleus/Noradrenergic System: Its Role In Regulating Working Memory / Attention and Interaction with the Cholinergic System | p. 349 |
| Noradrenergic Control of Long-Term Memory Consolidation | p. 353 |
| Role of the Locus Coeruleus-Norepinephrine System in Attention and Behavioral Flexibility | p. 357 |
| Adjusting Behavior to Context: Striatal Network Functions In Learning and Memory | p. 361 |
| Bdnf-Dependent Behavioral Sensitization in Hemiparkinsonian Rats | p. 365 |
| Reinforcement Neuronal Signals and Dimensionality Reduction in the Cortico-Basal Ganglia System | p. 369 |
| Effects of Histaminergic Drugs on Dopaminergic and Cholinergic Brain Activity in the Rat: Relevance For Mechanisms of Memory and Reward | p. 373 |
| Involvement of the Basal Ganglia and Dopamine System in Learning and Execution of Goal-Directed Behavior | p. 377 |
| Molecular Mechanism of the Regulation of the Biological Clock in Mammals | p. 381 |
| Activation of Hypocretin Neurons and Sleep | p. 385 |
| Catecholamines and Drugs of Abuse | |
| N-Methyl-D-Aspartate Receptors in Opioid Dependence and Withdrawal | p. 389 |
| The Mechanisms of Morphine Dependence and it's Withdrawal Syndrome--Study in Mutant Mice: Catecholamines and Addiction | p. 393 |
| Involvement of Enhanced Gene Expression of Antiopioid Systems in Morphine Tolerance and Dependence | p. 397 |
| Neocortical Gene Expression Associated with Behavioral Sensitization to Psychostimulants | p. 401 |
| Neuroimaging on Methamphetamine Users with Psychiatric Symptoms | p. 405 |
| Involvement of Catecholamines in Clinical Medicine | |
| Dopamine Psychosis in Schizophrenia? Molecular Genetic Study on Delusional Disorder | p. 409 |
| Dopamine Receptors in Schizophrenia | p. 413 |
| The Dopamine Hypothesis of Schizophrenia: New Aspects | p. 417 |
| Molecular Genetic Analysis of Plasma Dopamine [beta]-Hydroxylase in Depression: New Implications for An Old Biomarker | p. 423 |
| Dopaminergic Hyperactivity in Striatum in Schizophrenia: A Failure of Cortical Glutamatergic Control? | p. 427 |
| Tetrahydrobiopterin Differentially Regulates the Biosynthesis of Catecholamines and Serotonin: Implication in Neuropsychiatric Disorders | p. 431 |
| Lithium and Signal Transduction | p. 435 |
| Platelet Monoamine Oxidase, Transcription Factor AP-2 and Personality--A Functional Triangle? | p. 439 |
| Cardiac Sympathetic Denervation in Parkinson's Disease | p. 443 |
| Dopaminergic Impairment is Related to Cortical Dysfunction in Parkinson's Disease: A Pet Study | p. 449 |
| Aliphatic Propargylamines as Treatments for Neurodegenerative Diseases: Catecholamine Research--From Molecular Insights to Clinical Medicine | p. 455 |
| [beta]-Carbolines and N-Methylation Underlying Parkinson's Disease | p. 459 |
| Neuroprotective Actions of Green Tea Polyphenol, (-)-Epigallocatechin-3-Gallate in Models of Parkinson's Disease: Gene Targets | p. 463 |
| Dopamine Transporter and Parkinson's Disease | p. 467 |
| L-Dopa Responsive Dystonia/Infantile Parkinsonism Associated with Mutations at the Human Tyrosine Hydroxylase Locus | p. 471 |
| Dopamine is a Pathogenetic Factor in Hiv-Induced Neuro-Aids | p. 475 |
| Models of Parkinson's Disease | p. 479 |
| The Effect of Acute Loading with Selegiline and Selegiline with Levodopa on Blood Pressure and Plasma Norepinephrine Levels in Chronic Parkinsonian Patients | p. 483 |
| Cardiac Sympathetic Imaging with Radiolabelled Metaiodobenzylguanidine (Mibg) in Patients with Parkinson's Disease | p. 487 |
| Mibg Scintigraphy in Parkinsonian Syndromes | p. 491 |
| Evaluation of Sympathetic Nerve Function in Patients with Heart Failure by Mibg Myocardial Scintigraphy | p. 495 |
| Familial Orthostatic Tachycardia Due to Norepinephrine Transporter (SLC6A2) Deficiency | p. 499 |
| Sympathetic Innervation and Blood Flow in the Diabetec Heart | p. 505 |
| Dynamic Monitoring of Neurological Diseases by Csf Clinical Markers | p. 509 |
| Comparative Physiology and Morphology of Catecholamine Systems: Beta Adrenergic Receptor-Mediated Attenuation of TNF[alpha]-Stimulated ICAM-1 Expression on Human Brain Microvascular Endothelial Cells | p. 513 |
| Cloning of Novel Genes from the Human Spinal Cord by Molecular Profiling | p. 517 |
| Molecular Biology of Conformational Diseases | p. 521 |
| An Approach to Establish Antemortem Diagnosis of Dementia with Lewy Bodies | p. 525 |
| Sympathoadrenal Activity and Cardiovascular Responses During Space Flight | p. 529 |
| Estrogen Metabolism: Does the Formation of Estrogen Quinone Provide a Potential Pathway to Breast Carcinogenesis? | p. 533 |
| Index | p. 537 |
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