Chlamydia Pneumoniae and Chronic Diseases : Proceedings of the State-of-the-Art Workshop, Held at the Robert Koch-Institut Berlin, on 19 and 20 March 1999

By: Johanna L'age-Stehr (Editor)

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International specialists in Microbiology, Infectious Diseases, Internal Medicine, Cardiology Immunology, Pneumonology, Neurology and Epidemiology gathered to this workshop to discuss and enhance interdisciplinary knowledge on the possible etiological role of Chlamydia pneumoniae, a widespread human respiratory infection, in the pathogenesis of chronic inflammatory diseases with major public health impact such as atherosclerosis, cardiovascular disease, adult-onset asthma bronchiale, chronic obstructive pulmonary diseases, reactive arthritis, morbus Alzheimer and multiple sclerosis. Current deficits and goals in the standardisation of diagnostic tools, basic and applied research, design of epidemiological and monitoring of therapy studies were identified. A special feature of this book is the comprehensive collection of state-of-the-art review articles in the various fields with many references.

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Introduction	p. 1
Pathogenic mechanisms of chronic Chlamydia infections	p. 3
Biology, immunology and persistence of Chlamydia pneumoniae: Links to chronic disease	p. 8
Animal models for Chlamydia pneumoniae infection	p. 19
Molecular biology and serodiagnostics of Chlamydia pneumoniae - potential way to a vaccine	p. 25
Direct detection of Chlamydia pneumoniae in atherosclerotic plaques	p. 33
Detection of Chlamydia pneumoniae DNA in white blood cells	p. 42
Detection of Chlamydia pneumoniae in clinical specimens by PCR-EIA	p. 48
State of the art in the diagnosis of acute and chronic Chlamydia pneumoniae infection	p. 52
Epidemiological data on respiratory tract infection with Chlamydia pneumoniae and clinical complications	p. 63
Role of C. pneumoniae in severe asthma and COPD: Epidemiology and treatment	p. 68
Chlamydia pneumoniae in atherosclerosis	p. 73
Prevalence of Chlamydia pneumoniae in human coronary plaques with acute coronary syndrome	p. 84
Chlamydial lipopolysaccharide and Atherosclerosis	p. 91
Clinical trial designs to study antibiotic intervention in atherosclerosis	p. 97
Why antibiotics against Chlamydia pneumoniae for treatment of atherosclerotic disease could fail	p. 103
Atherosclerosis: Why the search for a causative infectious agent is not warranted	p. 108
Chlamydia infections and arthritis	p. 112
Chlamydia pneumoniae, APOE genotype, and Alzheimer's disease	p. 121
Association of Chlamydia pneumoniae with Multiple Sclerosis: Protocol for detection of C. Pneumoniae in the CSF and summary of preliminary results	p. 137
Trends and variations of chronic diseases in populations - Can infectious agents help to solve the puzzles?	p. 153
The epidemiology of Chlamydia pneumoniae versus the epidemiology of potential Chlamydial diseases (Atherosclerosis, Multiple Sclerosis, M. Alzheimer)	p. 163
The high male mortality of coronary heart diseases can be explained as a result of chronic infection	p. 171
The Spandauer Gesundheitstest - Retrospective cohort study on Chlamydia pneumoniae infections and cardiovascular disease - A study concept	p. 178
Public health impact of atherosclerosis and Chlamydia pneumoniae infections - What do we know and what to expect from future research	p. 184
Table of Contents provided by Blackwell. All Rights Reserved.

Chlamydia Pneumoniae and Chronic Diseases : Proceedings of the State-of-the-Art Workshop, Held at the Robert Koch-Institut Berlin, on 19 and 20 March 1999

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Paperback

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