Chronic Lung Disease in Early Infancy

Name: Chronic Lung Disease in Early Infancy
Brand: INFORMA MEDICAL
Price: 312.25 AUD
Availability: BackOrder

By: Richard D. Bland (Editor), Jacqueline J. Coalson (Editor)

Write A Review

Hardcover | 21 September 1999 | Edition Number 1

At a Glance

Hardcover
1096 Pages

Dimensions(cm)
22.86 x 16.51 x 4.45

Hardcover

RRP $441.00

$312.25

29%OFF

or 4 interest-free payments of $78.06 with

Available for Backorder. We will order this from our supplier however there isn't a current ETA.

This definitive volume presents the clinical and pathological features of bronchopulmonary dysplasia, a disease that accounts for the majority of long-term hospitalizations, slow growth, and recurrent early childhood respiratory ailments that are common in low-birth-weight newborns.
Highlights relevant animal models for studying the process of chronic lung disease through its evolution and during recovery!
Written by nearly 75 leading international authorities on lung disease during early childhood development who describe the clinical, radiographic, and pathological changes that have occurred in the 30 years since bronchopulmonary dysplasia was first discovered, Chronic Lung Disease in Early Infancy

focuses on the development of technology, notably changes in the application of assisted ventilation

traces the evolution and impact of new therapies, including prenatal glucocorticoids and postnatal surfactants

suggests effective therapeutic and preventive strategies

explains how the lungs develop structurally and functionally

explores how lung development is altered by injury and the repair process

critically examines research in the field of pediatric lung pathology

reviews what is known and emphasizes what needs to be learned about bronchopulmonary dysplasia

provides direction for future research into chronic lung disease

and more!

Industry Reviews

..".describes the clinical, radiographic, and pathologic changes that have occurred since the discovery of bronchopulmonary dysplasia 30 years ago....highlights include...animal models that can be used to study the process of chronic lung disease through its evolution and during recovery. "-Pulmonary Reviews ...an extensive and detailed review of bronchopulmonary dysplasia. -Doody's Health Sciences Book Reviews "clearly written. an extremely valuable source of information for anyone who has an interest in the biology of lung. should be available in the library of any hospital. "-Respiratory Care "valuable and well organized. ..should be an essential book for any chemist working in the area of solid state electrochemistry. "-Journal of Solid State Electrochemistry

Shipping

	Standard Shipping	Express Shipping
Metro postcodes:	$9.99	$14.95
Regional postcodes:	$9.99	$14.95
Rural postcodes:	$9.99	$14.95

How to return your order

At Booktopia, we offer hassle-free returns in accordance with our returns policy. If you wish to return an item, please get in touch with Booktopia Customer Care.

Additional postage charges may be applicable.

Defective items

If there is a problem with any of the items received for your order then the Booktopia Customer Care team is ready to assist you.

For more info please visit our Help Centre.

You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Paediatric Medicine Neonatal Medicine Respiratory Medicine Diseases & Disorders Infectious & Contagious Diseases

Introduction	p. iii
Preface	p. v
Contributors	p. vii
Clinical Aspects
Historical Perspective: Early Observations and Subsequent Evolution of Bronchopulmonary Dysplasia	p. 1
Introduction and Background	p. 1
Historical Perspective	p. 2
Early Observations	p. 5
The Evolution of BPD	p. 8
References	p. 14
Epidemiology of Bronchopulmonary Dysplasia: Clinical Risk Factors and Associated Clinical Conditions	p. 21
Introduction	p. 21
Major Perinatal Clinical Risk Factors for BPD	p. 22
Clinical Risk Scoring Systems	p. 29
Postnatal Factors That Affect BPD	p. 32
Summary	p. 36
References	p. 36
Clinical Course and Lung Function Abnormalities During Development of Neonatal Chronic Lung Disease	p. 41
Introduction	p. 41
Definition and Incidence	p. 42
Clinical Presentation	p. 43
Differential Diagnosis of CLD	p. 53
Lung Function During Development of CLD	p. 54
Therapeutic Interventions and Lung Function During Development of CLD	p. 57
References	p. 59
Radiographic Features of BPD and Potential Application of New Imaging Techniques	p. 65
Introduction	p. 65
The Radiographic Progression of BPD	p. 65
BPD as a Chronic Lung Disease	p. 68
New Imaging Techniques	p. 72
Potential Applications	p. 74
References	p. 79
Pathology of Chronic Lung Disease of Early Infancy	p. 85
Introduction	p. 85
Comparison of Classic BPD Pathology with BPD Pathology in the 1990s	p. 86
Major Differences in "Old" BPD Versus "New" BPD Pathology: Airway and Interstitial Disease	p. 101
Alveolar Hypoplasia and Vascular Dysmorphic Changes: The Consistent Findings in New BPD	p. 108
Pathogenesis of BPD in the 1990s	p. 114
Summary	p. 117
References	p. 118
The Usefulness of Bronchoalveolar Lavage in Infants with Evolving Chronic Lung Disease	p. 125
Introduction	p. 125
General Considerations	p. 126
Inflammation: Marker or Protagonist of Injury?	p. 132
Clinical Usefulness of BAL in BPD	p. 139
Conclusion	p. 140
References	p. 141
Inflammatory Mediators in Neonatal Lung Disease	p. 147
Introduction	p. 147
Neutrophils and Macrophages	p. 148
Neutrophil and Macrophage Recruitment	p. 149
Cytokines	p. 150
Elastolytic Damage	p. 152
Inflammatory Mediators and Pulmonary Infections	p. 153
Pulmonary Protein Leaks	p. 154
Oxygen Toxicity	p. 155
Conclusions and Outlook	p. 156
References	p. 157
Infection in the Pathogenesis of Bronchopulmonary Dysplasia	p. 163
Introduction	p. 163
Epidemiological Correlations	p. 164
Pathogenetic Mechanisms	p. 167
References	p. 169
Ventilation Strategies and Bronchopulmonary Dysplasia	p. 173
Introduction	p. 173
Barotrauma Versus Volutrauma	p. 174
Site of Pathology and Ventilatory Strategy	p. 176
Modes of Conventional Ventilators	p. 181
High-Frequency Ventilation	p. 183
Strategies to Minimize Barotrauma	p. 186
Liquid Ventilation	p. 192
Weaning from Mechanical Ventilation	p. 195
Other Forms of Respiratory Support	p. 196
Future Needs	p. 198
Summary	p. 199
References	p. 200
Effect of Respiratory Care Practices on the Development of Bronchopulmonary Dysplasia	p. 209
Introduction	p. 209
Gas Temperature and Humidity	p. 210
Aspiration	p. 229
Conclusions	p. 232
References	p. 233
Influence of Surfactant Replacement on Development of Bronchopulmonary Dysplasia	p. 237
Statement of the Question	p. 237
Review of the Clinical Data	p. 238
Why Should Surfactant Treatments Decrease BPD?	p. 241
Why Surfactant Treatment Might Not Affect the Incidence of BPD	p. 246
Summary	p. 251
References	p. 252
Drug Treatment for Established BPD	p. 257
Introduction	p. 257
Oxygen Therapy	p. 259
Diuretic Therapy	p. 260
Inhaled Bronchodilator Therapy	p. 264
Anti-Inflammatory Therapy	p. 267
Nutrition Therapy	p. 269
Other Drug Treatments for BPD	p. 272
Future Research Directions	p. 273
Summary	p. 275
References	p. 276
Nutritional Issues in Chronic Lung Disease of Premature Infants	p. 285
Introduction	p. 285
Negative Influence of General Undernutrition and Protein Malnutrition on Oxygen-Induced Lung Injury	p. 286
Lipid and Oxygen-Induced Lung Injury: Helpful or Harmful?	p. 287
Influence of Additional Nutrients (Inositol, Selenium, and Vitamin A) on Oxygen-Induced Lung Injury	p. 291
Conclusion	p. 293
References	p. 293
Pulmonary Function in BPD and Its Aftermath	p. 297
Introduction	p. 297
Clinical Evaluation of Infants and Children with BPD	p. 298
Growth Failure in Infants with BPD	p. 299
Exacerbations with Intercurrent Illness	p. 300
Techniques, Interpretation, and Limits of Pulmonary Function Testing in Infants with BPD	p. 301
Pulmonary Function in BPD: Infancy and Beyond	p. 306
Conclusions and Future Directions	p. 313
References	p. 314
Cardiovascular Abnormalities in Bronchopulmonary Dysplasia	p. 321
Introduction	p. 321
Disturbances in Cardiovascular Function	p. 323
Therapeutic Strategies	p. 336
Summary	p. 346
References	p. 346
Long-Term Recovery from Bronchopulmonary Dysplasia	p. 357
Introduction	p. 357
Physical Examination	p. 359
Pulmonary Function	p. 359
Airway Hyperreactivity	p. 361
Radiographic Study of the Chest	p. 362
Concluding Remarks	p. 364
References	p. 364
The Goal: Prevention of BPD	p. 367
Introduction	p. 367
Predisposing Factors	p. 369
References	p. 374
Normal and Abnormal Alveolar and Airway Development
Unique Features of the Immature Lung That Make It Vulnerable to Injury	p. 377
Introduction	p. 377
The Airways	p. 378
The Parenchyma	p. 387
References	p. 396
Hormonal Effects on Lung Maturation and Disease	p. 405
Introduction	p. 405
Prenatal Corticosteroid Therapy and Newborn Lung Disease	p. 406
Effects of Thyroid Hormones on Lung Maturation	p. 408
Combined Glucocorticoid and Thyroid Hormone Treatment	p. 409
Clinical Trials of Antenatal Corticosteroid Plus TRH Therapy	p. 419
Summary	p. 422
References	p. 423
Mechanisms and Physiological Sequelae of Reactive Species Injury to the Alveolar Epithelium	p. 431
Introduction and Purpose	p. 431
Structure of the Newborn and Adult Alveolar Epithelium	p. 432
Oxidant Stress in the Developing Lung	p. 433
Biology of Reactive Oxygen and Nitrogen Species	p. 434
NO-Derived Effects on the Alveolar Epithelium	p. 439
Lesson from Basic Research: Development of Rational Therapeutic Interventions to Limit Oxidant Injury	p. 449
References	p. 450
Surfactant in Chronic Lung Injury	p. 457
Introduction	p. 457
Composition and Functions of Pulmonary Surfactant	p. 458
Experimental Studies on Surfactant in Chronic Lung Injury	p. 462
Involvement of Surfactant in Patients with Chronic Lung Injury	p. 469
Conclusions	p. 471
References	p. 472
The Regulation of the Formation of Pulmonary Alveoli	p. 479
Introduction	p. 479
Architectural Maturation of the Lung's Gas-Exchange Region: From Saccules to Alveoli	p. 480
Formation of Alveoli	p. 481
Relation of Experimental Work to the Lung and Its Development in Prematurely Born Infants with Bronchopulmonary Dysplasia	p. 488
References	p. 489
Factors Mediating Cell Growth in Lung Injury	p. 493
Introduction	p. 493
Regulation of Cell Division	p. 494
Regulation of Normal Lung Growth by Growth Factors	p. 498
The Influence of Physical Factors on Lung Cell Growth	p. 503
The Influence of Oxygen on Lung Cell Growth	p. 506
Epithelial-Mesenchymal Interactions in Lung Injury	p. 509
Specific Growth Factors in Lung Injury	p. 510
Problems of Interpretation	p. 513
Foci for Future Research	p. 514
References	p. 515
Developmental Airway Structure and Function in Health and Chronic Lung Injury	p. 535
Introduction	p. 535
Developmental Morphology	p. 536
Functional Characteristics of the Immature Airway	p. 547
Clinical Assessment of Airway Function	p. 555
Summary	p. 561
References	p. 562
Normal and Abnormal Development of the Lung Circulation and Interstitium
Lung Development and the Effects of Chronic Hypoxia	p. 569
Introduction	p. 569
Normal Development of the Human Lung	p. 569
Effect of Chronic Hypoxia on Lung Development	p. 579
The Future: Where Do We Go from Here?	p. 589
References	p. 591
Altered Development of the Pulmonary Circulation in Chronic Lung Injury	p. 597
Introduction	p. 597
Structural Changes in Pulmonary Arteries	p. 598
Acute and Chronic Infection	p. 598
Hypoxia	p. 609
Oxygen Toxicity and Barotrauma	p. 610
High Flow and Pressure	p. 610
Chronic Lung Injury: Questions to Be Solved	p. 614
References	p. 614
Pulmonary Hypertension in Chronic Lung Disease of Infancy: Pathogenesis, Pathophysiology, and Treatment	p. 619
Introduction	p. 619
Perinatal Pulmonary Circulation: Developmental Aspects	p. 621
Effects of Lung Injury on the Developing Pulmonary Circulation	p. 626
Pulmonary Hypertension in Premature Neonates with Severe RDS	p. 633
Pulmonary Hypertension in CLD of Infancy	p. 636
Conclusions and Future Directions	p. 649
References	p. 650
Connective Tissues in Lung Development and Diseases in Early Infancy	p. 669
Introduction	p. 669
Extracellular Matrix: General	p. 670
ECM Proteins in Lung Development	p. 685
Connective Tissue Changes in Lung Diseases of Early Infancy	p. 688
Future Directions	p. 695
References	p. 697
Pulmonary Edema After Premature Birth: Progression from Acute to Chronic Lung Disease	p. 711
Introduction	p. 711
Lung Fluid Balance During Fetal Development	p. 713
Postnatal Lung Fluid Balance	p. 718
Lingering Questions	p. 735
References	p. 737
Mechanisms of Lung Injury and Repair During Development
Molecular Mechanisms of Oxygen-Induced Lung Injury	p. 749
Introduction	p. 749
Possible Roles of Hyperoxic Lung Injury in CLD	p. 750
Reactive Oxygen Species in Hyperoxic Lung Injury	p. 753
Biomarkers of Reactive Oxygen Species in Biological Systems	p. 754
Roles of Iron Metabolism in Reactive Oxygen-Mediated Tissue Injury	p. 768
Summary and Conclusions	p. 769
References	p. 769
Assessment of Tissue Injury from Reactive Oxygen Metabolites	p. 779
Introduction	p. 779
Methods	p. 783
Future Directions	p. 786
References	p. 786
Chronic Lung Disease of Early Infancy: Role of Neutrophils	p. 793
Introduction	p. 793
Mechanisms of Neutrophil-Mediated Injury and Recruitment to the Lung	p. 793
Pathological and Clinical Studies of Neutrophil Involvement in BPD	p. 796
The Role of Neutrophils in Animal Models of BPD	p. 801
Conclusions	p. 804
References	p. 806
The Role of Pulmonary Macrophages in Chronic Lung Disease of Early Infancy	p. 813
Introduction	p. 813
Emergence of Pulmonary Macrophage Populations and the Pathophysiology of CLD of Early Infancy	p. 814
The Role of Pulmonary Macrophages and Lung Infection in the Pathophysiology of CLD of Early Infancy	p. 816
Interactions of Lung Macrophages with Other Pulmonary Cells by Direct Cell-to-Cell Communication and Secretory Activity	p. 822
Limitations to the Study of Alveolar Macrophages in CLD of Early Infancy and Future Directions	p. 830
References	p. 832
Oxidants and Antioxidants: What Role Do They Play in Chronic Lung Disease?	p. 841
Introduction	p. 841
General Principles of Oxidants and Antioxidants	p. 842
Evidence Linking Oxygen Radicals and CLD	p. 845
Development of the AOE System in the Fetal Lung	p. 845
Vulnerability of the Premature Infant Relative to Antioxidant Defenses	p. 847
Experimental and Potential Therapeutic Modification of Antioxidant Defenses	p. 849
Oxygen Toxicity, Antioxidant Enzymes, and CLD: Unanswered Questions and Future Clinical Applications	p. 852
References	p. 853
Proteolytic Enzymes and Their Inhibitors in Lung Health and Disease	p. 859
Introduction	p. 859
Classification of Proteases	p. 860
Control of Proteolytic Enzymes	p. 863
Functions of Proteolytic Enzymes	p. 868
Proteases and Pulmonary Diseases	p. 870
Proteases and Chronic Lung Disease of Early Infancy	p. 872
What Lies Ahead?	p. 873
References	p. 875
Site- and Mechanism-Directed Interventions for Tissue Free Radical Injury	p. 883
Introduction	p. 883
Oxidant-Protective Reactions of Nitric Oxide	p. 884
Targeting Catalytic Radical Scavengers to the Extracellular Compartment	p. 890
Targeting Catalytic Radical Scavengers to the Intracellular Compartment	p. 894
Gene Therapy Strategies for Enhancing Pulmonary Antioxidant Defenses	p. 898
Summary	p. 900
References	p. 901
Models of Lung Injury and Repair During Development
Genetic Models for the Study of Autocrine--Paracrine Signaling in Lung Development and Repair	p. 911
Introduction	p. 911
Role of Fibroblast Growth Factors	p. 912
TGF-[alpha] and EGF-R Signaling and Pulmonary Fibrosis and Airspace Remodeling	p. 917
Bronchopulmonary Dysplasia	p. 923
Summary	p. 924
References	p. 924
Animal Models of Chronic Lung Injury	p. 927
Introduction	p. 927
What Is the Human Disease That Needs to Be Modeled?	p. 928
Contributors to the Development of BPD	p. 929
Potential Uses of Transgenic Models for Future Studies	p. 941
Summary and Future Needs	p. 945
References	p. 946
Author Index	p. 957
Subject Index	p. 1043
Table of Contents provided by Syndetics. All Rights Reserved.

Chronic Lung Disease in Early Infancy

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

More in Paediatric Medicine

Paediatric Handbook

10th edition

The Australian Autism Handbook

The essential guide to parenting a child on the autism spectrum

Advanced Paediatric Life Support, Australia and New Zealand

The Practical Approach

Mary Sheridan's From Birth to Five Years

5th Edition - Children's Developmental Progress

The Handbook of Child and Adolescent Clinical Psychology

A Contextual Approach

Illustrated Textbook of Paediatrics

6th edition

The Circle of Security Intervention

Enhancing Attachment in Early Parent-Child Relationships

Life Story Therapy with Traumatized Children

A Model for Practice

Creative Interventions with Traumatized Children: 2nd Edition

Creative Arts and Play Therapy

Helping Your Child with PDA Live a Happier Life

Asperger's Syndrome

A Guide for Parents and Professionals

Play Therapy

The Art of the Relationship

Child and Adolescent Mental Health

3rd Edition - Theory and Practice

Case-Smith's Occupational Therapy for Children and Adolescents

8th edition

Pediatric Audiology : 3rd Edition

Diagnosis, Technology, and Management

Pediatric Audiology Casebook

2nd Edition

Pediatric Endoscopic Endonasal Skull Base Surgery

Smart Foods for ADHD and Brain Health

How Nutrition Influences Cognitive Function, Behaviour and Mood

Creative Play-Based DBT Activities for Children and Their Caregivers

From Birth to Five Years

2nd Edition - Practical Developmental Examination

The Survival Guide for Kids with Autism Spectrum Disorder (and Their Parents)

Survival Guides for Kids

Nelson Textbook of Pediatrics, 2-Volume Set

Nelson Textbook of Pediatrics

RadCases Plus Q &A Pediatric Imaging

Second Edition

Handbook of Pediatric Orthopaedics

Third Edition

This product is categorised by