Clinical Applications of Mass Spectrometry
Methods and Protocols
By: Uttam Garg (Editor), Catherine A. Hammett-Stabler (Editor)
Paperback | 23 August 2016
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556 Pages
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As mass spectrometric methods now offer a level of specificity and sensitivity unrealized by spectrophotometric- and immunoassay-based methods, mass spectrometry has entered the clinical laboratory where it is being used for a wide range of applications. In Clinical Applications of Mass Spectrometry: Methods and Protocols, expert researchers provide detailed step-by-step procedures for the analysis of number of analytes of clinical importance. This versatile and expansive volume covers mass spectrometry methods for analytes including a variety of drugs, hormones, and metabolic compounds spanning the disciplines of toxicology, therapeutic drug monitoring, endocrinology, and pediatric metabolism. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include brief introductions to the analytes, lists of the necessary materials and reagents, readily reproducible analytical protocols, and detailed notes on troubleshooting and avoiding known pitfalls.
Comprehensive and dependable, Clinical Applications of Mass Spectrometry: Methods and Protocols offers its readers a wide array of valuable methods for experienced mass spectrometric labs that are looking to introduce new analyses as well as for those laboratories currently considering the addition of this resourceful and vital technology.
Industry Reviews
From the reviews:
"This book provides a collection of over 50 applications of GC-MS, LC-MS, and ICP-MS for screening, identification, and quantification of clinically relevant analytes in body samples. ... It can be recommended ... to critical practitioners in laboratory medicine." (Hans H. Maurer, Analytical and Bioanalytical Chemistry, Vol. 399, 2011)
"Clinical Applications of Mass Spectrometry Methods and Protocols is a compilation of ready-to-use protocols for the determination of clinically relevant analytes in various biological matrices. ... the book is a straightforward compilation of diverse protocols written in a very user-friendly format. It is especially valuable for labs that have just started implementing mass spectrometry or for those planning to do so in the near future. For labs with more experience in mass spectrometry, the protocols can save many hours of precious method development time." (Robert Jansen, Journal of the American Society for Mass Spectrometry, Vol. 22, 2011)
2. Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry Nathalie Lepage and Susan Aucoin
3. Comprehensive Determination of Amino Acids for Diagnosis of Inborn Errors of Metabolism Dennis J. Dietzen and Annette L. Weindel
4. Identification and Quantitation of Amphetamine, Methamphetamine, MDMA, Pseudoephedrine, and Ephedrine in Blood, Plasma, and Serum Using Gas Chromatography-Mass Spectrometry (GC/MS) Josh Gunn, Scott Kriger, and Andrea R. Terrell
5. Quantification of Antidepressants Using Gas Chromatography-Mass Spectrometry Ruth E. Winecker
6. Quantitation of Argatroban in Plasma using Liquid Chromatography Electrospray Tandem Mass Spectrometry (UPLC-ESI-MS/MS) Ross J. Molinaro
7. Quantitation of Amobarbital, Butalbital, Pentobarbital, Phenobarbital, and Secobarbital in Urine, Serum, and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Leonard L. Johnson and Uttam Garg
8. Quantitation of Benzodiazepines in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves
9. LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium Stephanie J. Marin and Gwendolyn A. McMillin
10. Simultaneous Determination and Quantification of 12 Benzodiazepines in Serum or Whole Blood Using UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell
11. Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS) Jeff M. Knoblauch, David K. Scott, Laurie D. Smith, and Uttam Garg
12. Quantification of Busulfan in Plasma Uing Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Marion L. Snyder and James C. Ritchie
13. Quantitation of Total 11-Nor-9-Carboxy-Delta 9-Tetrahydrocannabinol in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) C. Clinton Frazee III, Michael Kiscoan, and Uttam Garg
14. Quantitation of Cocaine, Benzoylecgonine, Ecgonine Methyl Ester, and Cocaethylene in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Steven W. Fleming, Amitava Dasgupta, and Uttam Garg
15. Identification and Quantitation of Cocaine, Benzoylecgonine, and Cocaethylene in Blood, Serum, and Plasma Using Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry (UPLC-MS/MS) Scott Kriger, Josh Gunn, and Andrea R. Terrell
16. Detection and Quantification of Cocaine and Benzoylecgonine in Meconium Using Solid Phase Extraction and UPLC/MS/MS Josh Gunn, Scott Kriger, and Andrea R. Terrell
17. Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma and Urine Qin Sun and William E. O'Brien
18. Broad Spectrum Drug Screening Using Electron-Ionization Gas Chromatography-Mass Spectrometry (EI-GCMS) Judy Stone
19. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry Judy Stone
20. High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS Mark M. Kushnir, Alan L. Rockwood, Bingfang Yue, and A. Wayne Meikle
21. 3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett
22. Quantitation of Fentanyl in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves
23. Determination of Total Homocysteine in Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC/MS/MS) Bruno Casetta
24. Quantitation of Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine Using Gas Chromatography-Mass Spectrometry (GC/MS) Ryan Allenbrand and Uttam Garg
25. Quantitation of 17-OH-Progesterone (OHPG) for Diagnosis of Congenital Adrenal Hyperplasia (CAH) Ravinder J. Singh
26. Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC/MS) David K. Scott, Kathleen Neville, and Uttam Garg
27. Quantitation of Ibuprofen in Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Gerry Huber and Uttam Garg
28. Quantitation of Indomethacin in Serum and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS) Sarah Thomas, Amanda Sutton, and Uttam Garg
29. Quantitation of Iothalamate in Urine and Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Ross J. Molinaro and James C. Ritchie
30. Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Megan Gamble, and Kim Cox
31. Measurement of Filter Paper Bloodspot Lead by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) Denise M. Timko and Douglas F. Stickle
32. Multiplex Lysosomal Enzyme Activity Assay on Dried Blood Spots Using Tandem Mass Spectrometry X. Kate Zhang, Carole S. Elbin, Frantisek Turecek, Ronald Scott, Wei-Lien Chuang, Joan M. Keutzer, and Michael Gelb
33. Gas Chromatography-Mass Spectrometry Method for the Determination of Methadone and 2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine (EDDP) Christine L.H. Snozek, Matthew W. Bjergum, and Loralie J. Langman
34. Liquid Chromatography-Tandem Mass Spectrometry (LC-MSMS) Method for Monitoring Methotrexate in the Setting of Carboxypeptidase-G2 Therapy Vikram S. Kumar, Terence Law, and Mark Kellogg
35. Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett
36. Quantitation of Methylmalonic Acid in Plasma Using Liquid Chromatography-Tandem Mass Spectrometry Claudine Fasching and Jasbir Singh
37. Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry Catherine A. Hammett-Stabler, Diane Ciuffetti Geis, James Ritchie, and Christine Papadea
38. Quantitation of Nicotine, Its Metabolites, and Other Related Alkaloids in Urine, Serum, and Plasma Using LC-MS/MS Bingfang Yue, Mark M. Kushnir, Francis M. Urry, and Alan L. Rockwood
39. Quantitation of Opioids in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves
40. Quantitation of Morphine, Codeine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, and 6-Monoacetylmorphine (6-MAM) in Urine, Blood, Serum, or Plasma Using Liquid Chromatography with Tandem Mass Spectrometry Detection Tim Dahn, Josh Gunn, Scott Kriger, and Andrea R. Terrell
41. Urine Organic Acid Analysis for Inherited Metabolic Disease Using Gas Chromatography-Mass Spectrometry Patricia M. Jones and Michael J. Bennett
42. Identification of Urine Organic Acids for the Detection of Inborn Errors of Metabolism Using Urease and Gas Chromatography-Mass Spectrometry (GC/MS) Stanley F. Lo, Velta Young, and William J. Rhead
43. Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry Jie Chen and Michael J. Bennett
44. Quantitation of Oxycodone in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS) Bruce A. Goldberger, Chris W. Chronister, and Michele L. Merves
45. Quantitation of Phencyclidine (PCP) in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS) Angela M. Ferguson and Uttam Garg
46. Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) Magdalena Korecka and Leslie M. Shaw
47. Quantitation of Tacrolimus in Whole Blood Using High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC/MS/MS) Keri J. Donaldson and Leslie M. Shaw
48. Analysis of Testosterone in Serum Using Mass Spectrometry Robert L. Fitzgerald, Terrance L. Griffin, and David A. Herold
49. Determination of Tetrahydrozoline in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC/MS) Judy Peat and Uttam Garg
50. Quantitation of 25-OH-Vitamin D (25OHD) Using Liquid Tandem Mass Spectrometry (LC-MS/MS) Ravinder J. Singh
51. Identification and Quantitation of Zolpidem in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Lydia A. Harryman, and Melissa C. Norton
52. Identification and Quantitation of Zopiclone in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS) Timothy P. Rohrig, Melissa C. Norton, and Lydia A. Harryman
ISBN: 9781493957422
ISBN-10: 1493957422
Series: Methods in Molecular Biology
Published: 23rd August 2016
Format: Paperback
Language: English
Number of Pages: 556
Audience: Professional and Scholarly
Publisher: Springer Nature B.V.
Country of Publication: US
Dimensions (cm): 25.4 x 17.78 x 2.87
Weight (kg): 0.95
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