Clinical Proteomics

By: Antonia Vlahou (Editor)

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Hardcover | 1 April 2008

At a Glance

Hardcover
424 Pages

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23.39 x 15.6 x 2.39

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The field of clinical proteomics has rapidly evolved during the past few years and is continuously growing as new methodologies and technologies emerge. In Clinical Proteomics , a select group of leading researchers has contributed their state-of-the-art methodologies on protein profiling and identification of disease biomarkers in tissues, microdissected cells and body fluids. Experimental approaches involving the application of two-dimensional electrophoresis, multi-dimensional liquid chromatography, SELDI/MALDI mass spectrometry and protein arrays, as well as the bioinformatic and statistical tools pertinent to the analysis of proteomics data, are thoroughly detailed in these readily reproducible methods and protocols, explained through the step-by-step instructional format of the highly successful Methods in Molecular Biologya?? series. With its multi-disciplinary approach, Clinical Proteomics provides integrated, cutting-edge techniques sure to be invaluable to a wide range of researchers including clinicians, molecular biologists, chemists, bioinformaticians and computational biologists.

Industry Reviews

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"Clinical proteomics is a fledgling field that is struggling to define its standards and whose underlying technologies continue to evolve at a very rapid pace. ... This multiauthored book provides state-of-the-art information and practical protocols on these topics and many other related areas. ... provides a wealth of background information and underlying principles. ... Overall, this is an excellent book whose natural readership includes both newcomers to the field and seasoned biomarker hunters who wish to update their knowledge or explore new techniques." (Marco Crescenzi, Annali dell'Istituto Superiore di Sanita, Vol. 44 (3), November, 2008)

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You Can Find This Book In

Non-Fiction Science Biology, Life Sciences Molecular Biology Medicine Clinical & Internal Medicine Pre-Clinical Medicine & Basic Sciences Physiology Medicine in General Medical Equipment & Techniques Medical Research Anatomy

Cytology Biochemistry Proteins

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Paperback

Published: 19th November 2010

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Preface	p. v
Acknowledgments	p. vii
Contributors	p. xiii
Overview and Introduction to Clinical Proteomics	p. 1
Specimen Collection for Clinical Proteomics
Specimen Collection and Handling: Standardization of Blood Sample Collection	p. 35
Tissue Sample Collection for Proteomics Analysis	p. 43
Clinical Proteomics by 2DE and Direct MALDI/SELDI MS Profiling
Protein Profiling of Human Plasma Samples by Two-Dimensional Electrophoresis	p. 57
Analysis of Laser Capture Microdissected Cells by 2-Dimensional Gel Electrophoresis	p. 77
Optimizing the Difference Gel Electrophoresis (DIGE) Technology	p. 93
MALDI/SELDI Protein Profiling of Serum for the Identification of Cancer Biomarkers	p. 125
Urine Sample Preparation and Protein Profiling by Two-Dimensional Electrophoresis and Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy	p. 141
Combining Laser Capture Microdissection and Proteomics Techniques	p. 159
Clinical Proteomics by LC-MS Approaches
Comparison of Protein Expression by Isotope-Coded Affinity Tag Labeling	p. 181
Analysis of Microdissected Cells by Two-Dimensional LC-MS Approaches	p. 193
Label-Free LC-MS Method for the Identification of Biomarkers	p. 209
Analysis of the Extracellular Matrix and Secreted Vesicle Proteomes by Mass Spectrometry	p. 231
Clinical Proteomics and Antibody Arrays
Miniaturized Parallelized Sandwich Immunoassays	p. 247
Dissecting Cancer Serum Protein Profiles Using Antibody Arrays	p. 263
Statistics and Bioinformatics in Clinical Proteomics Data Analysis
2D-PAGE Maps Analysis	p. 291
Finding the Significant Markers: Statistical Analysis of Proteomic Data	p. 327
Web-Based Tools for Protein Classification	p. 349
Open-Source Platform for the Analysis of Liquid Chromatography-Mass Spectrometry (LC-MS) Data	p. 369
Pattern Recognition Approaches for Classifying Proteomic Mass Spectra of Biofluids	p. 383
Index	p. 397
Table of Contents provided by Ingram. All Rights Reserved.

Clinical Proteomics

At a Glance

Hardcover

Industry Reviews

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Defective items

You Can Find This Book In

Other Editions and Formats

Paperback

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