Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors

By: Eric Wickstrom (Editor)

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Hardcover | 21 April 1998 | Edition Number 1

At a Glance

Hardcover
448 Pages

Dimensions(cm)
23.39 x 15.6 x 2.54

Hardcover

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An important new collection of clinical and preclinical reports on genetic therapy, this book describes illustrative examples of diseases in which gene-based interventions are presently plausible, and presents case studies of current research using both synthetic oligonucleotides and biological vectors.
Combining the insights of over 50 contributors, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors

furnishes a historical overview of genetic therapy

highlights official Food and Drug Administration positions on the preparation of oligonucleotides and vectors

offers practical models of agent preparation, animal testing, pharmacokinetics, toxicology, and clinical trials

discusses both synthetic DNA and biological vector approaches to cancer, viral, and cardiological indications

illustrates for new practitioners how each stage of genetic therapy is developed

details genetic treatment of leukemia; lymphoma; cancer of the brain, breast, colon, kidney, and lung; melanoma; HIV; and coronary restenosis

includes examples of antisense, ribozyme, tumor suppressor, immunostimulation, and gene replacement therapy

and addresses questions of preparation, delivery, toxicity, mechanism, and specificity.

Industry Reviews

"This volume clearly demonstrates that genetic therapy is underway, and that the efforts described are soundly based in rationale and feasibilityOur increasing understanding of the mechanisms of conversion of the genetic code into function indicate that gene based therapy will become a mainstay of disease control in the 21st century. "-O. Michael Colvin, Duke University Medical Center, Durham, North Carolina

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A Brief History of Genetic Therapy: Gene Therapy
Technology, and Genomics
Preclinical Development of Oligonucleotide Therapeutics for Cancer: Regulatory Aspects
Commercial Scale Manufacturing of Oligonucleotides Under Good Manufacturing Practices
The Regulatory Process and Gene
Table of Contents provided by Publisher. All Rights Reserved.

Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

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