Colorectal Cancer

Dedication...Preface...Table of Contents...Contributing Authors...Part I Molecular Basis of Colorectal Cancer 1 Cell Line Models of Molecular Subtypes of Colorectal Cancer Jennifer Mooi, Ian Luk, and John Mariadason2 Dissecting Oncogenic RTK Pathways in Colorectal Cancer Initiation and Progression Stephen McManus, Walid Chababi, Dominique Arsenault, Claire M. Dubois, and Caroline Saucier3 Identification of Response Elements on Promoters Using Site Directed Mutagenesis and Chromatin Immunoprecipitation Salah Boudjadi, Julie C. Carrier, and Jean-Francois Beaulieu4 Identification and Functional Analysis of Gene Regulatory Sequences Interacting with Colorectal Tumor Suppressors Katja Dahlgaard and Jesper Thorvald Troelsen5 Methods for In Vivo Functional Studies of Chromatin-Modifying Enzymes in Early Steps of Colon Carcinogenesis Martine Chevillard-Briet and Fabrice Escaffit6 The Colorectal Cancer Microenvironment: Strategies for Studying the Role of Cancer Associated Fibroblasts Rahul Bhome, Massimiliano Mellone, Katherine Emo, Gareth Thomas, Emre Sayan, and Alex H. Mirnezami7 Methods for Assessing Apoptosis and Anoikis in Normal Intestine/Colon and Colorectal Cancer Pierre H. Vachon8 Molecular Analysis of the Microbiome in Colorectal Cancer Fiona Clegg, Susan H. Berry, Richard Hansen and Georgina L. Hold9 Proteomic Analysis of Colorectal Cancer Cells Anais Chauvin and Francois-Michel Boisvert10 Autophagic Flux Assessment in Colorectal Cancer Cells Annie Lauzier and Steve Jean Part II New Developments in Colorectal Cancer Diagnostics and Screening11 Classification of Colorectal Cancer in Molecular Subtypes by Immunohistochemistry Sanne ten Hoorn, Anne Trinh, Joan de Jong, Lianne Koens, and Louis Vermeulen12 Stool DNA Integrity Method for Colorectal Cancer Detection Claudia Rengucci, Giulia De Maio, Maura Menghi, and Daniele Calistri13 RT-qPCR for Fecal Mature microRNA Quantification and Validation Farid E. Ahmed, Nancy C. Ahmed, Mostafa M. Gouda, Paul W. Vos, and Chris Bonnerup14 A Stool Multi-Target mRNA Assay for the Detection of Colorectal Neoplasms Elizabeth Herring, Shigeru Kanaoka, Eric Tremblay, and Jean-Francois Beaulieu15 Colorectal Cancer Detection Using Targeted LC-MS Metabolic Profiling Danijel Djukovic, Jiangjiang Zhang, and Daniel Raftery16 Proteomic Profiling for Colorectal Cancer Biomarker Discovery Paula Alvarez-Chaver, Loretta De Chiara, and Vicenta Soledad Martinez-Zorzano17 Tumor-Derived Microparticles to Monitor Colorectal Cancer Evolution Diane Mege, Laurence Panicot-Dubois, and Christophe DuboisPart III Recent Advances in Colorectal Cancer Therapeutics18 Molecular Testing for the Treatment of Advanced Colorectal Cancer: An Overview Patrick S. Lin and Thomas J. Semrad19 Testing Cell-Based Immunotherapy for Colorectal Cancer Jong Soon Kang, Yeo Dae Yoon, Myeong Youl Lee, Chang Woo Lee, Suk Jong Lee, and Sang-Bae Han20 Patient-Derived Xenograft Models of Colorectal Cancer: Procedures for Engraftment and Propagation Danielle M. Burgenske, David J. Monsma, and Jeffrey P. MacKeigan21 Use of Organoids to Characterize Signaling Pathways in Cancer Initiation Christina Oatway, Calley L. Hirsch, and Alex Gregorieff22 Identification of Novel Molecules Targeting Cancer Stem Cells Yannick D. Benoit