Cyclic DNA Adducts

By: Helmut Bartsch (Editor), Bea Singer (Editor)

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Paperback | 1 December 1999

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A major goal in the fight against cancer is the reduction of cancer mortality rates. This can only be achieved in one of two ways: reducing incidence rates, and increasing the chances of cure. The chances of cancer being cured can be estimated from the probability of survival. Measures of incidence, survival and mortality are critical to the interpretation of data on progress in the fight against cancer, and in the evaluation of the overall effectiveness of cancer controlprogrammes. The present volume includes survival comparisons based on data from 40 populations in 17 European countries and shows important differences, both between countries and over time. The differences revealed between populations will help European countries to establish reasonable and attainable goalsfor cancer diagnosis and treatment. National health authorities will wish to promote further research in order to understand full y the reasons for differences in survival so that suitable action may be taken to correct them.

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Non-Fiction Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical Chemistry Organic Chemistry Medicine Clinical & Internal Medicine Diseases & Disorders Oncology Medicine in General

Public Health & Preventive Medicine Epidemiology & Medical Statistics Infectious & Contagious Diseases Pre-Clinical Medicine & Basic Sciences Medical Genetics Medical Equipment & Techniques Medical Laboratory Testing & Techniques

Contributors
Foreword
Acknowledgements
Abbreviations
Keynote address: Exocyclic adducts as new risk markers for DNA damage in man	p. 1
Chemistry and biology of DNA damage by malondialdehyde
Formation and repair of DNA adducts in vinyl chloride- and vinyl fluoride-induced carcinogenesis	p. 29
Role of 1,N[superscript 2]-propanodeoxyguanosine adducts as endogenous DNA lesions in rodents and humans	p. 45
Lipid peroxidation-induced etheno-DNA adducts in humans	p. 55
Detection of 1,N[superscript 6]-etheno-2'-deoxyadenosine and 3,N[superscript 4]-etheno-2'-deoxycytidine occurring endogenously in DNA	p. 63
Possible mechanisms of carcinogenesis after exposure to benzene
Synthesis of para-benzoquinone and 1,3-bis(2-chloroethyl)-nitrosourea adducts and their incorporation into oligonucleotides	p. 89
Purine DNA adducts of 4,5-dioxovaleric acid and 2,4-decadienal	p. 103
Adducts of chlorohydroxyfuranones and of aldehyde conjugates	p. 115
Cyclic adducts and intermediates induced by simple epoxides	p. 123
Formation of etheno adducts and their effects on DNA polymerases
Reactions of [alpha]-acetoxy-N-nitrosopyrrolidine and crotonaldehyde with DNA	p. 147
Glyoxal - guanine DNA adducts: Detection, stability and formation in vivo from nitrosamines	p. 155
Effects of 3,N[superscript 4]-etheno-deoxycytidine on duplex stability and energetics
Solution structures of DNA duplexes containing the exocyclic lesion 3,N[superscript 4]-etheno-2'-deoxycytidine	p. 179
Thermal destabilization of DNA oligonucleotide duplexes by exocyclic adducts on adenine or cytosine depends on both the base and the size of the adduct	p. 191
A sensitive immunoslot-blot assay for detection of malondialdehyde - deoxyguanosine in human DNA
[superscript 32]P-Postlabelling with high-performance liquid chromatography for analysis of abundant DNA adducts in human tissues	p. 205
Cancer risk assessment for crotonaldehyde and 2-hexenal: An approach	p. 219
Mammalian enzymatic repair of etheno and para-benzoquinone exocyclic adducts derived from the carcinogens vinyl chloride and benzene
Enzymology of the repair of etheno adducts in mammalian cells and in Escherichia coli	p. 249
Cellular response to exocyclic DNA adducts	p. 263
Role of base excision repair in protecting cells from the toxicity of chloroethylnitrosoureas	p. 271
Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis	p. 279
Cancer-prone oxyradical overload disease
Role of etheno DNA adducts in carcinogenesis induced by vinyl chloride in rats	p. 303
Vinyl chloride-specific mutations in humans and animals	p. 315
Solution conformation and mutagenic specificity of 1,N[superscript 6]-ethenoadenine	p. 325
Genetic effects of exocyclic DNA adducts in vivo: Heritable genetic damage in comparison with loss of heterozygosity in somatic cells	p. 335
Distortion of the double helix by para-benzoquinone adducts	p. 351
Subject index	p. 357
Table of Contents provided by Blackwell. All Rights Reserved.

Cyclic DNA Adducts

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