Cytokine Knockouts

By: Giamila Fantuzzi

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Hardcover | 30 July 2003 | Edition Number 2

At a Glance

Hardcover
492 Pages

Edition Type
Revised

Dimensions(cm)
25.4 x 17.78 x 2.69

Hardcover

$349.17

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Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.

Industry Reviews

Foreword by Scott K. Durum
Reviews of the first edition:
...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. -from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne
". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal

"...essential reading for...laboratory scientists, including immunologists, developmental and cell biologists, and experimental pathologists..."
-Modern Pathology

"...a very nice compendium of research in a very important area...should be on the shelves of all life science/biomedical libraries."
-Doody's Health Sciences Book Review Journal

"This remarkable book is a powerful source of information and ideas."
-Annales de Biologie Clinique

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Foreword
Preface
List of Contributors
Cytokine Knockouts in Inflammation	p. 3
The Use of Cytokine Knockouts to Study Host Defense Against Infection	p. 11
The Use of Cytokine Knockouts in Animal Models of Autoimmune Disease	p. 33
The Use of Cytokine Knockout Mice in Cancer Research	p. 57
The Use of Cytokine Knockout Mice in Neuroimmunology	p. 73
The Role of IL-1 in the Immune System	p. 95
IL-1 Receptor Antagonist-Deficient Mice	p. 111
A Unique Role for IL-2 in Self-Tolerance	p. 135
Molecular Basis for Binding Multiple Cytokines by [gamma]c: Implications for X-SCID and Impaired [gamma]c-Dependent Cytokine Receptor Function	p. 151
G-CSF, GM-CSF, and IL-3 Knockout Mice	p. 171
IL-4 Knockout Mice	p. 187
Role of IL-5 in Immune and Pathological Responses in the Mouse	p. 203
IL-6 Knockout Mice	p. 213
IL-10 and IL-2 Knockout Mice: Effect on Intestinal Inflammation	p. 237
IL-12-Deficient Mice	p. 253
IL-13 and Double IL-4/IL-13 Knockout Mice	p. 269
IL-15: Insights from Characterizing IL-15-Deficient Mice	p. 281
IL-18 and IL-18 Receptor Knockout Mice	p. 303
Mice Knockouts for Chemokines and Chemokine Receptors	p. 323
IFN-[gamma] and IFN-[gamma] Receptor Knockout Mice	p. 347
Macrophage Migration Inhibitory Factor (MIF)-Deficient Mice	p. 361
Osteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout Mice	p. 379
RANKL, RANK, and OPG	p. 395
Targeting the TGF-[beta] Pathway In Vivo: Defining Complex Roles for TGF-[beta] Signaling in Immune Function, Wound Healing, and Carcinogenesis	p. 421
Physiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout Models	p. 439
Index	p. 461
Table of Contents provided by Blackwell. All Rights Reserved.

Cytokine Knockouts

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

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