DNA Conjugates and Sensors

By: Keith R Fox (Editor), Tom Brown (Editor)

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Hardcover | 18 October 2012

At a Glance

Hardcover
316 Pages

Dimensions(cm)
25.4 x 15.88 x 2.54

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$458.75

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Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book is relevant to researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.

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Nucleic Acid Sensors for SERRS
Quadruplexes as sensors
Click Chemistry
Fluorophore conjugates for single-molecule work
Chromophore-functionalized LNAs and their use in exploratory diagnostic applications
Small molecule-DNA conjugates
DNAzymes
Electrochemical aptamer based sensors
Small molecule-RNA conjugates
DNA pH sensors
Oligonucleotide-conjugates for detection
Oligonucleotide-conjugates as artificial Enzymes
Aptamers as diagnostic and therapeutic reagents
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.

DNA Conjugates and Sensors

At a Glance

Hardcover

Shipping

How to return your order

Defective items

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