PREFACE.
CONTRIBUTORS.
PART I: INTRODUCTION.
1. Introduction to Zinc Enzymes as Drug Targets (Claudiu T.
Supuran and Jean-Yves Winum).
PART II: DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND
ACTIVATORS.
2. Carbonic Anhydrases as Drug Targets: General Presentation
(Claudiu T. Supuran).
3. Zinc Binding Functions in the Design of Carbonic Anhydrase
Inhibitors (Jean-Yves Winum, Jean-Louis Montero, Andrea
Scozzafava, and Claudiu T. Supuran).
4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and
Its Importance in Drug Design (Vincenzo Alterio, Anna Di Fiore,
Katia D?Ambrosio, Claudiu T. Supuran, and Giuseppina De
Simone).
5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic
Drugs (Francesco Mincione, Andrea Scozzafava, and Claudiu T.
Supuran).
6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward
Novel Applications for Sulfonamide Drugs (Daniela Vullo, Alessio
Innocenti, and Claudiu T. Supuran).
7. Drug Design of Carbonic Anhydrase Inhibitors as
Anticonvulsant Agents (Anne Thiry, Jean-Michel Dogne,
Claudiu T. Supuran, and Bernard Masereel).
8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic,
Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII
(Silvia Pastorekova, Monika Barathova, Juraj Kopacek, and
Jaromir Pastorek).
9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for
Carbonic Anhydrase IX (Alessandro Cecchi, Laura Ciani, Sandra
Ristori, and Claudiu T. Supuran).
10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors
(Giuseppina De Simone and Claudiu T. Supuran).
11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition
(Jean-Michel Dogne, Anne Thiry, Bernard Masereel, and
Claudiu T. Supuran).
12. Advances in the Inhibitory and Structural Investigations on
Carbonic Anhydrase Isozymes XIII and XV (Mika Hilvo, Giuseppina
De Simone, Claudiu T. Supuran, and Seppo Parkkila).
13. Mechanism and Inhibition of the b-Class and c-Class Carbonic
Anhydrases (James G. Ferry and Claudiu T. Supuran).
14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in
Drug Design (Rebecca A. Hall and Fritz. A.
M?uhlschlegel).
15. Crystallographic Studies on Carbonic Anhydrases from Fungal
Pathogens for Structure-Assisted Drug Development (Uta-Maria
Ohndorf, Christine Schlicker, and Clemens Steegborn).
16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in
the Development of Novel Therapies of Malaria (Jerapan
Krungkrai, Sudaratana R. Krungkrai, and Claudiu T.
Supuran).
17. Inhibitors of Helicobacter pylori a- and b-Carbonic
Anhydrases as Novel Drugs for Gastroduodenal Diseases (Isao
Nishimori, Hiroaki Takeuchi, and Claudiu T. Supuran).
18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on
Drug Design (Adriano Martinelli and Tiziano Tuccinardi).
19. Selectivity Issues in the Design of CA Inhibitors
(Claudiu T. Supuran and Jean-Yves Winum).
20. Bicarbonate Transport Metabolons (Danielle E. Johnson and
Joseph R. Casey).
21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase
Inhibitors (Marc A. Ilies).
22. Drug Design Studies of Carbonic Anhydrase Activators
(Claudia Temperini, Andrea Scozzafava, and Claudiu T.
Supuran).
PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE
INHIBITORS.
23. Matrix Metalloproteinases: An Overview (Hideaki Nagase
and Robert Visse).
24. MMP Inhibitors Based on Earlier Succinimide Strategies: From
Early to New Approaches (M. Amelia Santos).
25. Drug Design of Sulfonylated MMP Inhibitors (Armando
Rossello and Elisa Nuti).
26. ADAMs and ADAMTs Selective Synthetic Inhibitors (Armando
Rossello, Elisa Nuti, and Alfonso Maresca).
27. QSAR Studies of MMP Inhibitors (Tiziano Tuccinardi and
Adriano Martinelli).
PART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE
INHIBITORS.
28. Bacterial Zinc Proteases as Orphan Targets (Claudiu T.
Supuran).
29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor
Inhibitors (Antonio Mastrolorenzo and Claudiu T.
Supuran).
30. Clostridium histolyticum Collagenase Inhibitors in the Drug
Design (Claudiu T. Supuran).
31. Other Bacterial Zinc Peptidases as Potential Drug Targets
(Kunihiko Watanabe).
PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING
ENZYMES.
32. Angiotensin Converting Enzyme (ACE) Inhibitors (Ana
Camara-Artigas, Vicente Jara-Perez, and Montserrat
Andujar-Sanchez).
33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops
leucurus Venom: Isolation and Possible Inhibition (Eladio F.
Sanchez and Johannes A. Eble).
34. CaaX-Protein Prenyltransferase Inhibitors (Martin
Schlitzer, Regina Ortmann, and Mirko Altenkamper).
35. Histone Deacetylase Inhibitors (Paul W. Finn).
36. Recent Development of Diagnostic and Therapeutic Agents
Targeting Glutamate Carboxypeptidase II (GCPII) (Youngjoo Byun,
Ronnie C. Mease, Shawn E. Lupold, and Martin G. Pomper).
37. Targeting HIV-1 Integrase Zinc Binding Motif (Mario
Sechi, Mauro Carcelli, Dominga Rogolino, and Nouri
Neamati).
38. Inhibitors of Histidinol Dehydrogenases as Antibacterial
Agents (Pascale Joseph, Franc¸ois Turtaut, Stephan
K?ohler, and Jean-Yves Winum).
39. Dihydroorotase Inhibitors (Mihwa Lee, Megan J. Maher,
Richard I. Christopherson, and J. Mitchell Guss).
40. APOBEC3G: A Promising Antiviral Target (Claudiu T.
Supuran and Jean-Yves Winum).
Index.
