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200 Pages
18.0 x 25.4 x 1.8
Hardcover
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Industry Reviews
1. History and Nomenclature
Pick's Disease: The Contributions of Arnold Pick
Maintaining Early Traditions and Refining Diagnosis: Delay, Brion, Escourolle, Malamud and Constantinidis
Splintering of Pick's Disease into Multiple Subtypes
Corticobasal Degeneration (CBD) - Rebeiz, Gibbs, Riley & Lang
Frontal Lobar Dementia of the Non-Alzheimer Type, Dementia of the Frontal Type, Frontotemporal Dementia & Frontotemporal Lobar Degeneration: Brun Gustafson, Neary, Bowen, Snowden, Mann
Primary Progressive Aphasia (PPA): Marsel Mesulam, Norman Geschwind, John Hodges, Julie Snowden, Karalyn Patterson and Marilu Gorno-Tempini
UCLA and UCSF Studies
The Biological Revolution
Genetics
Neuropathology
FTD Now: Where Are We?
The Future
References
2. The Clinical Syndrome of bvFTD
Overview
Case History
Comment
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Alzheimer's Disease
Psychiatric Disorders
Movement Disorders
Chronic Traumatic Encephalopathy
Other FTD Clinical Phenotypes
Vascular Dementia
Metabolic Causes
Structural Brain Abnormalities
Treatment
Medications used to alleviate bvFTD symptoms
bvFTD: Current State and Research Advances
References
3. The Temporal Variant of FTD
Overview
Case History
Comment
Clinical Features and Anatomy
Right Temporal Lobe Syndrome
Creativity
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
svPPA: Current State and Research Advances
Semantic Knowledge and the Anterior Temporal Lobes
Autoimmunity, Left-Handedness, Head Trauma and svPPA
Summary
References
4. Progressive Nonfluent/Agrammatic Aphasia
Overview
Case History
Comment
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
nfvPPA: Current State and Research Advances
Diagnosis from Clinical Syndrome to Molecular Diagnosis
Neurolinguistic and Neuroplasticity Discoveries
References
5. Related Disorders: FTD-ALS
Overview
Amyotrophic Lateral Sclerosis
Case History
Comment
Clinical Features and Anatomy
El Escorial Criteria
Genetic and Pathological Correlates
Neuropathology
Differential Diagnosis
Treatment
FTD-ALS: Current State and Research Advances
Clinical-Pathological Considerations
Molecular Considerations
References
6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy
Overview
Corticobasal Syndrome (CBS) and Corticobasal Degeneration (CBD)
Case History
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
Progressive Supranuclear Palsy (PSP)
Case History
Clinical Features and Anatomy
Genetic and Pathological Correlates
Differential Diagnosis
Treatment
CBD and PSP: Current State and Research Advances
Clinical Dilemmas
New Discoveries on the Pathogenesis of CBD, PSP and other Tauopathies
Neuroimaging
Basic Biological Advances
Clinical Trials for Tauopathies
References
7. A Primer of FTLD Neuropathology
General Features
Overview of Tau-Related Neuropathology in FTLD
Overview of TDP-43 and FUS Related Neuropathology in FTLD
Gross Anatomical and Microscopic Changes in FTLD
Tau Aggregates
Pick's Disease
PSP and CBD
Argyrophilic Grain Disease
FTLD with Ubiquitin- and TDP-43-positive Inclusions
FTLD with Tau and TDP-43-Negative but FUS-Positive Inclusions
SQSTM1 and FTLD
Dementia Lacking Distinctive Histopathology (DLDH)
Special Features of FTLD Pathology
Hippocampal Sclerosis
Von Economo Neurons
FTLD Neuropathology: Current State and Research Advances
What is the Role of TDP-43 in Non-FTLD Degenerative Conditions: Alzheimer's Disease and Chronic Traumatic Encephalopathy?
Basic Mechanisms in TDP-43, FUS and C9ORF72
Does FTLD Spread in a Prion-like Fashion?
FTD Pathology Glossary
References
8. FTD Genes
Overview
Genes Implicated in FTD
MAPT
GRN
C9ORF72
Valosin-containing-Protein ATPase (VCP)
TARDBP
FUS
CHMP2B
SQSTM1 and Ubiquilin 2
Genes That Modify FTD Expression
Management and Genetic Counseling
References
9. FTD Reflections Upon Psychology and Philosophy
Emotions
The Self
Free Will
Religious Beliefs
Psychology
Social and Emotional Functioning
Executive Control
von Economo Neurons
References
10. Treatments
Diagnosis
bvFTD: Targeting Symptoms, Educating the Family
svPPA: Targeting Symptoms, Educating the Family
nfvPPA: Targeting Symptoms and Educating the Family
Late Stages of FTD
Early Interventions
Pharmacological Review
Selective Serotonin Reuptake Inhibitors (SSRIs)
Atypical Antipsychotics
Acetylcholinesterase inhibitors (AChEIs)
NMDA-Receptor Antagonist
Dextromethorphan Hydrobromide and Quinidine Sulfate for Pseudobulbar Affect
Valproic Acid
Gabapentin
Oxytocin
Non-Pharmacological Therapies
Complementary and Alternative Medicine
Language Impairment
Future Treatments
Tau
Progranulin
TDP-43, FUS, C9ORF72
Conclusions
References
ISBN: 9780195380491
ISBN-10: 0195380495
Series: Contemporary Neurology Series
Published: 15th May 2014
Format: Hardcover
Language: English
Number of Pages: 200
Audience: Professional and Scholarly
Publisher: Oxford University Press USA
Country of Publication: US
Dimensions (cm): 18.0 x 25.4 x 1.8
Weight (kg): 0.66
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