G Protein-Coupled Receptors

Structure, Function, and Ligand Screening

By: Tatsuya Haga (Editor), Shigeki Takeda (Editor)

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Hardcover | 4 August 2005 | Edition Number 6

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Hardcover
336 Pages

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23.4 x 15.6 x 1.91

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With contributions from international experts in the fields of pharmacology, neuroscience, and biochemistry, this text provides an in-depth exploration of GPCRs. Coverage includes the screening of ligands for GPCRs, physiological and molecular characterizations of GPCRs, and structures of GPCRs and their ligands. The book explores current research issues in the post-genome era, particularly the identification of endogenous ligands that may lead to finding new hormones or neurotransmitters. It also discusses the determination of the tertiary structure of GPCRs, useful for understanding GPCR interactions and for the theoretical modeling of drugs.

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Screening of Ligands for GPCRs
Screening of Endogenous Ligands for Orphan GPCRs	p. 3
Screening of Ligands for Human GPCRs by the Use of Receptor-G[alpha] Fusion Proteins	p. 37
Screening and Identification of Ghrelin, an Endogenous Ligand for GHS-R	p. 67
Ligand Screening of Olfactory Receptors	p. 85
Functions and Regulations of GPCRs
Generation and Phenotypical Analysis of Muscarinic Acetylcholine Receptor Knockout Mice	p. 113
Systematic Mutagenesis of M[subscript 1] Muscarinic Acetylcholine Receptors	p. 137
Analysis of the Regulation of Muscarinic Acetylcholine Receptors	p. 179
Single-Molecule Analysis of Chemotactic Signaling Mediated by cAMP Receptor on Living Cells	p. 197
Oligomerization of G Protein-Coupled Purinergic Receptors	p. 219
Tertiary Structure of GPCRs and Their Ligands
Methods and Results in X-Ray Crystallography of Bovine Rhodopsin	p. 243
Determination of Steric Structure of Muscarinic Ligands Bound to Muscarinic Acetylcholine Receptors: Approaches by TRNOE (Transferred Nuclear Overhauser Effect)	p. 261
Modeling of G Protein-Coupled Receptors for Drug Design	p. 283
Index	p. 303
Table of Contents provided by Ingram. All Rights Reserved.

G Protein-Coupled Receptors

Structure, Function, and Ligand Screening

At a Glance

Hardcover

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