Part I. Introduction Introduction to Experimental Bone and Cartilage Histology Yuehuei H. An and Helen E. Gruber Part II. Structure and Function of Bone and Cartilage Cell Structure and Biology of Bone and Cartilage William R. Walsh, Mark Walton, Warwick Bruce, Yan Yu, Ronald M. Gillies, and Martin Svehla Normal Structure and Function of Bone Torben Steiniche and Ellen M. Hauge Structure and Function of Articular Cartilage Jerry C. Y. Hu and Kyriacos A. Athanasiou Part III. Tissue Harvesting, Fixation, and Preparation Bone-Labeling Techniques Reinhold G. Erben Human Bone Biopsy Robert S. Weinstein Biopsy Issues for Bone and Cartilage Tumors John L. Eady Tissue Harvesting and Fixation Linda L. Jenkins and Karen J. L. Burg Common Fixatives in Hard-Tissue Histology Antonio Scarano, Giovanna Iezzi, and Adriano Piattelli Decalcification of Bone Tissue Robert A. Skinner Principles of Embedding and Common Protocols Yuehuei H. An, Patricia L. Moreira, Qian K. Kang, and Helen E. Gruber Infiltration Techniques and Results in Different Types of Resin Antonio Scarano, Giovanna Orsini, and Adriano Piattelli Part IV. Sectioning Techniques Histological Techniques for Decalcified Bone and Cartilage Qian K. Kang, Jackie C. LaBreck, Helen E. Gruber, and Yuehuei H. An Techniques for Sectioning Undecalcified Bone Tissue Using Microtomes William L. Ries Cutting and Grinding Methods for Hard-Tissue Histology Thomas W. Bauer and Diane Mahovlic Bone Sectioning Using the Exakt System Karl Donath and Michael Rohrer Bone Sectioning Using a Modified Inner Diamond Saw Joop G. C. Wolke, Jan-Paul C. M. van der Waerden, Christel P. A. T. Klein, and John A. Jansen Bone Sectioning Using the Precise 1 Automated Cutting System Antonio Scarano, Manlio Quaranta, and Adriano Piattelli Bone, Cement, and Metal Implant Interface Preparation with a High-Pressure Water Cutter Jian-Sheng Wang and Lars Lidgren Part V. Staining Techniques Basic Staining and Histochemical Techniques and Immunohistochemical Localizations Using Bone Sections Helen E. Gruber and Jane A. Ingram Basic Staining Techniques for Cartilage Sections Helen E. Gruber and Jane A. Ingram Histochemical and Immunohistochemical Staining of Cartilage Sections Andreas G. Nerlich Staining Techniques for Plastic-Embedded Specimens Antonio Scarano, Giovanna Petrone, and Adriano Piattelli In Situ Hybridization of Bone and Cartilage Shintaro Nomura and Seiichi Hirota Part VI. Analysis Techniques Bone Histomorphometry: Concepts and Common Techniques Jean E. Aaron and Patricia A. Shore Histological Analysis of Bone-Implant Interface John A. Jansen Histomorphometric Analysis of Bone-Cement and Cement-Metal Interface Jian-Sheng Wang, Gonzalo G. Valdivia, Michael J. Dunbar, Cecil H. Rorabeck, Robert B. Bourne, and Suzanne Maher Histologic Analysis of Bone Healing Ryland B. Edwards, III, Mandi J. Lopez, and Mark D. Markel Histomorphometry of Metabolic Bone Conditions Ellen M. Hauge, Torben Steiniche, and Troels T. Andreassen Histology of Articular Cartilage Repair Stefan Nehrer and Myron Spector Histological Analysis of Cartilage Conditions Theodore R. Oegema, Jr., Cathy S. Carlson, and Ada A. Cole Histological Analysis of Soft-Tissues Biomaterial Interface: Relevance to Dental Implants Antonio Scarano, Gian Antonio Favero, Elisabetta Fiera, and Adriano Piattelli Pathological Diagnosis of Common Tumors of Bone and Cartilage Jasvir S. Khurana and Krishnan K. Unni Part VII. Electron Microscopy and Radiography Methods for Transmission and Scanning Electron Microscopy of Bone and Cartilage Helen E. Gruber and Winston W. Wiggins SEM Methods for Observation of the Bone-Implant Interface Masashi Neo and Takashi Nakamura TEM Methods for Observation of the Bone-Implant Interface Joseph Hemmerle Radiological Examination of Calcified Tissues with Emphasis on Bone Victor Fornasier and Charles L. Ho Microangiography, Macrosectioning, and Preparation for Contact Radiography Yebin Jiang, Yunzhao Wang, Dianmin Xue, and Yuming Yin Part VIII. Recognizing and Avoiding Artifacts Recognizing and Interpreting Histology Artifacts in Hard-Tissue Research Thomas W. Bauer Index.