Handbook of Small Animal Imaging

SECTION I: INTRODUCTION TO SMALL ANIMAL IMAGING, THERAPY AND APPLICATIONS. Defining Small Animal Imaging, Therapy and Applications. Ethics in Small Animal Imaging, Therapy and Translational Medicine. Small Animal Handling, Care and Anesthesia. Preclinical Models. SECTION II: SMALL ANIMAL IMAGING; IONIZING RADIATION. Early Years: Autoradiography and Radionuclide Imaging Employing Non-Tomographic. Techniques. Micro CT Imaging. Digital Subtraction Angiography (DSA). Single Photon Emission Computed Tomography (SPECT). Positron Emission Tomography (PET). SECTION III: SMALL ANIMAL IMAGING; NON-IONIZING RADIATION. MR Imaging. Ultrasound (US). Optical Imaging. SECTION IV: HYBRID IMAGING. Combined Anatomical - Functional Imaging. Optical - CT Imaging. CT - SPECT. PET - CT. MR - PET. Trimodality Imaging (SPECT - CT - PET, PET - CT - MRI). Exotic Imaging Approaches (Neutron Imaging, Terahertz Imaging). SECTION V: IMAGING AGENTS. Contrast Agents (CT, MRI, US). Radiochemistry. Molecular Targets and Optical Probes. SECTION VI: THERAPEUTIC RESEARCH PLATFORMS. Developing Technologies for Small Animal Therapy. Small Animal Dosimetry. Treatment Planning for Small Animals. Agents for Imaging and Therapy. SECTION VII: IMAGE QUANTIFICATION. Quantification of Small Animal Imaging. Performance Assessment of Small Animal Imaging Systems and Common Standards. Monte Carlo Simulation in Imaging. Monte Carlo Simulation in Therapy. SECTION VIII: APPLICATIONS. Small Animal Imaging and Therapy: How They Affect Patient Care. Drug Development. New Device Development: Surgical, Endoscopic and Intravascular Devices. Imaging of Intracellular Targets. Imaging of Cell Trafficking and Cell Tissue Homing. Imaging of Cardiovascular Disease. Imaging of Angiogenesis. Imaging in Oncology. Imaging of Hypoxia, Apoptosis, and Inflammation. Imaging of Brain / CNS Diseases. Vessel Wall Imaging. What is the Future of Small Animal Imaging, Therapy, and Translational Medicine?