Hedgehog Signaling

Name: Hedgehog Signaling
Brand: Academic Press
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Volume 88

By: Gerald Litwack

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Hardcover | 12 March 2012 | Edition Number 1

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584 Pages

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22.9 x 15.2 x 3.18

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hedgehog signaling.

Contributions from leading authorities
Informs and updates on all the latest developments in the field

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Non-Fiction Science Biology, Life Sciences Molecular Biology Engineering & Technology Agriculture & Farming Aquaculture & Fish-Farming Practice & Techniques Zoology & Animal Sciences Life Sciences in General

Contributors	p. xv
Preface	p. xxi
Hedgehog Signaling	p. 1
Hedgehog Ligands	p. 2
Hedgehog Signaling	p. 4
Hedgehog Signaling in Zebrafish Eye Vesicle Patterning	p. 5
Hedgehog Signaling in Zebrafish Photoreceptor Differentiation	p. 7
Hedgehog Signaling in Zebrafish Inner Nuclear Layer	p. 10
Hedgehog Signaling in Zebrafish Ganglion Cell Differentiation	p. 11
References	p. 18
Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies	p. 25
Hedgehog Introduction	p. 26
Regulation of Canonical HH Signaling and Its Implication in Cancer	p. 26
SMO-Independent Modulation of GLI Activity	p. 32
Hedgehog in Hematopoiesis and Hematopoietic Stem Cells	p. 35
From HSC to CML	p. 38
T- and B-Cell Malignancies	p. 39
Outlook	p. 44
Acknowledgments	p. 46
References	p. 46
Noncanonical Hedgehog Signaling	p. 55
Definition	p. 56
Type I Noncanonical Signaling: Pathways Engaged Exclusively by Ptc1	p. 56
Type II Noncanonical Signaling: Pathways Engaged by Smoothened	p. 61
Noncanonical Hh Signaling in Drosophila	p. 67
Concluding Remarks	p. 68
References	p. 68
Gli Protein Nuclear Localization Signal	p. 73
Introduction	p. 74
Nuclear Localization Signal and Nuclear Export Signal	p. 74
NLS and NES Mapping	p. 75
Sequence Comparison of Gli NLSs-NLSs in ZF Domains	p. 79
Predicted 3D Structure of Gli NLS	p. 81
NLS Control of Gli/Ci Subcellular Localization in Hh Signaling	p. 83
Perspectives	p. 86
References	p. 86
Mammalian Homologues of Drosophila Fused Kinase	p. 91
Introduction	p. 92
The Major Steps of Hh Signaling	p. 93
Ci/Gli Proteins are Transcription Factors Mediating Hh Activities	p. 94
Hedgehog Signaling Complex is Responsible for Regulation of ci Protein	p. 96
Regulation of Gli Proteins	p. 98
Fu is a Protein Kinase Playing Catalytic and Regulatory Roles in ci regulation	p. 99
Protein Kinases Participating in the Regulation of Gli Proteins	p. 100
Controversial Roles of Stk36	p. 101
The Role of Ulk3 in Shh Signaling Pathway	p. 103
An Emerging Shh Signaling Model Involving Ulk3	p. 106
Acknowledgments	p. 107
References	p. 107
Identification, Functional Characterization, and Pathobiological Significance of GLl1 Isoforms in Human Cancers	p. 115
Introduction	p. 116
Structures and Properties of GLl1 Isoforms	p. 117
Regulation of GLli Isoforms by Canonical and Noncanonical Pathways	p. 121
GLli Isoforms and Malignant Phenotypes of Cancer	p. 126
Conclusion and Future Directions	p. 133
Acknowledgments	p. 135
References	p. 135
Gli-Similar Proteins: Their Mechanisms of Action, Physiological Functions, and Roles in Disease	p. 141
Introduction	p. 142
Mechanism of Action of Glis Proteins	p. 144
Role of Glis Proteins in Renal Physiology and Pathology	p. 151
Role of Glis3 in Pancreas Physiology and Pathology	p. 155
Glis Functions in Other Tissues	p. 160
Conclusion	p. 163
Acknowledgments	p. 163
References	p. 163
Sonic Hedgehog Regulates Wnt Activity During Neural Circuit Formation	p. 173
Introduction	p. 174
Shh and Wnt Signaling: Canonical Signaling Pathways	p. 174
Patterning and Morphogenesis of the Neural Tube	p. 177
Establishment of Neuronal Polarization	p. 184
Axon Guidance	p. 186
Synapse Formation	p. 195
Other Factors Influencing Shh and Wnt Pathways	p. 197
Conclusions and Future Directions	p. 200
References	p. 201
Hedgehog/Gli Control by Ubiquitination/Acetylation Interplay	p. 211
Introduction	p. 212
Ubiquitin-Dependent Regulation of Hh Signaling	p. 213
Increasing the Complexity of Hh Signaling in Vertebrates: The Cul1- and Cul3-Dependent Ubiquitination Processes	p. 214
An Alternative Gli1 Control by the HECT-Type Itch E3 Ubiquitin Ligase-Based Processing	p. 215
Activation of Itch Function by Numb	p. 216
Acetylation to Ubiquitination Connection in Hh Signaling	p. 217
Implications of Ubiquitin-Dependent Events for Cell Development and Tumorigenesis	p. 218
Implications for Ubiquitination/Acetylation Interplay in Cell Development and Cancer Control	p. 220
Conclusions	p. 221
Acknowledgments	p. 222
References	p. 222
Palmitoylation of Hedgehog Proteins	p. 229
Introduction to Protein Palmitoylation	p. 230
Palmitoylation of Hedgehog Proteins	p. 231
Palmitoylation of Other Secreted Proteins	p. 240
The MBOAT Family of Acyltransferases	p. 242
Conclusions and Future Directions	p. 246
Acknowledgments	p. 246
References	p. 246
Phosphorylation Regulation of Hedgehog Signaling	p. 253
Introduction	p. 253
Phosphorylation of the Transcription Factor in Hh Signaling	p. 255
Phosphorylation of Smo Receptor in Hh Signaling	p. 257
Other Phosphorylation Events in Hh Signaling	p. 260
Nonconserved Phosphorylation	p. 262
Phosphatases in Hh Signaling	p. 263
Differential Phosphorylation of Hh Signaling Components	p. 264
Acknowledgments	p. 266
References	p. 266
Protein Kinase A Activity and Hedgehog Signaling Pathway	p. 273
Introduction	p. 274
Function of PKA in Hedgehog-Responsive Cells	p. 275
Activation of PKA	p. 279
PKA Activity in Hedgehog-Responding Cells	p. 284
Perspectives	p. 286
Acknowledgments	p. 287
References	p. 287
Phosphorylation of Gli by cAMP-Dependent Protein Kinase	p. 293
Introduction	p. 294
cAMP-Dependent Protein Kinase	p. 295
Hedgehog Signaling and cAMP-Dependent Protein Kinase	p. 297
Gli Transcription Factors and cAMP-Dependent Protein Kinase	p. 298
Conclusions	p. 301
References	p. 304
ZFP932 Suppresses Cellular Hedgehog Response and Patched1 Transcription	p. 309
Introduction	p. 310
Zfp932 Characterization	p. 312
ZFP932 Represses Ptch1 Expression	p. 315
ZFP932 Represses Cellular Hedgehog-Signaling Response	p. 327
ZFP932 Regulates Osteoblast Differentiation	p. 328
Conclusion	p. 330
Acknowledgments	p. 330
References	p. 331
A New Era for an Ancient Drug: Arsenic Trioxide and Hedgehog Signaling	p. 333
Historic Use of Arsenic in Medicine	p. 334
Molecular Mechanisms of Arsenic in Cancer Therapy	p. 335
Role of Hedgehog Signaling in Cancer	p. 339
Effect of Arsenic on Hh Signaling	p. 342
Conclusions	p. 345
References	p. 347
Aberrations and Therapeutics Involving the Developmental Pathway Hedgehog in Pancreatic cancer	p. 355
Introduction	p. 356
The Hedgehog Pathway	p. 357
Hedgehog Therapeutics	p. 362
Conclusion	p. 375
References	p. 375
Sonic Hedgehog Signaling and Potential Therapeutic Indications	p. 379
Sonic Hedgehog Discovered (Shh)	p. 380
Shh Signaling in Vertebrates	p. 380
Shh Second Messenger Systems	p. 383
Shh in Stem Cell Proliferation	p. 385
Shh in Oncogenesis	p. 387
Shh in Injury of the CNS	p. 389
Conclusion	p. 393
References	p. 393
Sonic Hedgehog on Microparticles and Neovascularization	p. 395
Introduction	p. 396
Neovascularization	p. 397
Sonic Hedgehog	p. 405
Microparticles	p. 415
Conclusion	p. 424
References	p. 425
"Patch"-ing up the Neurons: Revival or Enervation?	p. 439
Introduction	p. 440
The "Patched" Transmission	p. 442
Ptch1 Expression in Neural Tissues	p. 443
Ptch1 in Disease, Development, and Injury	p. 445
Conclusion	p. 453
Acknowledgments	p. 454
References	p. 454
Activation of Hedgehog Pathway in Gastrointestinal Cancers	p. 461
Introduction	p. 461
Activation of the Hh Pathway in Esophageal Cancer	p. 462
Activation of the Hh Pathway in Gastric Cancer	p. 464
Activation of the Hh Pathway in Colorectal Cancer	p. 466
Summary	p. 467
References	p. 467
The Role of Sonic Hedgehog as a Regulator of Gastric Function and Differentiation	p. 473
Introduction	p. 474
Hh in the Adult Stomach	p. 474
The Potential Role of Sonic Hh as a Gastric Hormone	p. 481
Conclusions and Future Directions	p. 484
Acknowledgment	p. 485
References	p. 485
Sonic Hedgehog-Mediated Synergistic Effects Guiding Angiogenesis and Osteogenesis	p. 491
General Introduction	p. 492
General Aspects of Shh Signaling	p. 492
The Role of Hh Morphogens in Bone Development and Repair	p. 493
Shh: Potential Candidate Linking Angiogenesis and Osteogenesis	p. 494
Effects of Shh on Angiogenesis, Vessel Maturation, and Osteogenesis	p. 494
Coculture Models as In Vitro Models to Investigate Effects of Shh on Osteogenesis and Angiogenesis	p. 496
Effects of Shh on Angiogenesis in a Coculture Model	p. 497
Effects of Shh on Osteogenesis in a Coculture Model	p. 499
Future Therapeutical Options and Delivery Strategies	p. 501
References	p. 502
Hedgehog Inhibition as an Anti-Cancer Strategy	p. 507
Introduction	p. 508
Hh Signaling in Normal Development	p. 508
Hh Pathway Alterations in Cancer	p. 509
Targeted Therapies for Hedgehog Dependent Cancers	p. 512
Conclusions and Future Directions	p. 516
Acknowledgments	p. 518
References	p. 519
Index	p. 523
Table of Contents provided by Ingram. All Rights Reserved.

Hedgehog Signaling

Volume 88

At a Glance

Hardcover

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How to return your order

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