| Preface to the Third Edition | p. xv |
| Introduction | |
| Origins and Early History of NMR | p. 2 |
| High Resolution NMR: An Overview | p. 5 |
| Additional Reading and Resources | p. 12 |
| The Theory of NMR | |
| Nuclear Spin and Magnetic Moment | p. 13 |
| Theoretical Descriptions of NMR | p. 14 |
| Steady-State Quantum Mechanical Description | p. 16 |
| Effect of the Boltzmann Distribution | p. 19 |
| Spin-Lattice Relaxation | p. 20 |
| Precession of Nuclear Magnetic Moments | p. 24 |
| Classical Mechanical Description of NMR | p. 27 |
| Magnetization in the Rotating Frame | p. 32 |
| Methods of Obtaining NMR Spectra | p. 33 |
| Dynamic Processes | p. 39 |
| Terminology, Symbols, Units, and Conventions | p. 43 |
| Additional Reading and Resources | p. 46 |
| Problems | p. 46 |
| Instrumentation and Techniques | |
| Advantages of Pulse Fourier Transform NMR | p. 49 |
| Basic NMR Apparatus | p. 51 |
| Requirements for High Resolution NMR | p. 52 |
| Detection of NMR Signals | p. 56 |
| Phase Cycling | p. 57 |
| Fourier Transformation of the FID | p. 60 |
| Data Acquisition | p. 61 |
| Data Processing | p. 68 |
| Digital Filtering | p. 72 |
| Alternatives to Fourier Transformation | p. 74 |
| Sensitivity and Size of Sample | p. 75 |
| Useful Solvents | p. 79 |
| Additional Reading and Resources | p. 80 |
| Problems | p. 81 |
| Chemical Shifts | |
| The Origin of Chemical Shifts | p. 83 |
| Theory of Chemical Shifts | p. 84 |
| Measurement of Chemical Shifts | p. 87 |
| Empirical Correlations of Chemical Shifts | p. 94 |
| Some Aspects of Proton Chemical Shifts | p. 94 |
| Nuclei Other Than Hydrogen | p. 107 |
| Compilations of Spectral Data and Empirical Estimates of Chemical Shifts | p. 108 |
| Isotope Effects | p. 109 |
| Effects of Molecular Asymmetry | p. 109 |
| Paramagnetic Species | p. 112 |
| Additional Reading and Resources | p. 114 |
| Problems | p. 115 |
| Coupling between Pairs of Spins | |
| Origin of Spin Coupling Interactions | p. 119 |
| General Aspects of Spin-Spin Coupling | p. 122 |
| Theory of Spin-Spin Coupling | p. 128 |
| Correlation of Coupling Constants with Other Physical Properties | p. 129 |
| Effect of Exchange | p. 132 |
| Spin Decoupling and Double Resonance | p. 133 |
| Additional Reading and Resources | p. 134 |
| Problems | p. 135 |
| Structure and Analysis of Complex Spectra | |
| Symmetry and Equivalence | p. 140 |
| Notation | p. 142 |
| Energy Levels and Transitions in an AX System | p. 143 |
| Quantum Mechanical Treatment | p. 145 |
| The Two-Spin System without Coupling | p. 148 |
| Factoring the Secular Equation | p. 150 |
| Two Coupled Spins | p. 151 |
| The AB Spectrum | p. 154 |
| AX, AB, and A[subscript 2] Spectra | p. 157 |
| "First-Order" Spectra | p. 158 |
| Symmetry of Spin Wave Functions | p. 161 |
| General Procedures for Simulating Spectra | p. 163 |
| Three-Spin Systems | p. 164 |
| Relative Signs of Coupling Constants | p. 168 |
| Some Consequences of Strong Coupling and Chemical Equivalence | p. 171 |
| "Satellites" from Carbon-13 and Other Nuclides | p. 175 |
| The AA'BB' and AA'XX' Systems | p. 176 |
| Additional Reading and Resources | p. 177 |
| Problems | p. 178 |
| Spectra of Solids | |
| Spin Interactions in Solids | p. 184 |
| Dipolar Interactions | p. 184 |
| "Scalar Coupling" | p. 187 |
| The Heteronuclear Two-Spin System | p. 187 |
| Dipolar Decoupling | p. 189 |
| Cross Polarization | p. 190 |
| The Homonuclear Two-Spin System | p. 191 |
| Line Narrowing by Multiple Pulse Methods | p. 192 |
| Anisotropy of the Chemical Shielding | p. 194 |
| Magic Angle Spinning | p. 195 |
| Quadrupole Interactions and Line-Narrowing Methods | p. 198 |
| Other Aspects of Line Shapes | p. 200 |
| Orientation Effects in Liquids: Liquid Crystals | p. 201 |
| Additional Reading and Resources | p. 203 |
| Problems | p. 203 |
| Relaxation | |
| Molecular Motions and Processes for Relaxation in Liquids | p. 206 |
| Nuclear Magnetic Dipole Interactions | p. 209 |
| Nuclear Overhauser Effect | p. 212 |
| Relaxation via Chemical Shielding Anisotropy | p. 215 |
| Electric Quadrupole Relaxation | p. 216 |
| Scalar Relaxation | p. 217 |
| Spin-Rotation Relaxation | p. 219 |
| Relaxation by Paramagnetic Substances | p. 220 |
| Other Factors Affecting Relaxation | p. 221 |
| Additional Reading and Resources | p. 224 |
| Problems | p. 224 |
| Pulse Sequences | |
| The Spin Echo | p. 228 |
| The Carr-Purcell Pulse Sequence | p. 233 |
| Correcting for Pulse Imperfections | p. 234 |
| Spin Locking | p. 236 |
| Selective Excitation | p. 237 |
| Decoupling | p. 242 |
| Polarization Transfer Methods | p. 243 |
| Additional Reading and Resources | p. 249 |
| Problems | p. 249 |
| Two-Dimensional NMR | |
| General Aspects of 2D Spectra | p. 251 |
| A Survey of Basic 2D Experiments | p. 259 |
| Data Acquisition and Processing | p. 268 |
| Sensitivity Considerations | p. 274 |
| Additional Reading and Resources | p. 277 |
| Problems | p. 277 |
| Density Matrix and Product Operator Formalisms | |
| The Density Matrix | p. 280 |
| Transformations of the Density Matrix | p. 287 |
| The One-Spin System | p. 289 |
| The Two-Spin System | p. 293 |
| INEPT and Related Pulse Sequences | p. 298 |
| Product Operators | p. 302 |
| Coherence Transfer Pathways | p. 311 |
| Additional Reading and Resources | p. 316 |
| Problems | p. 316 |
| Selected 1D, 2D, and 3D Experiments: A Further Look | |
| Spectral Editing | p. 317 |
| Double Quantum Filtering Experiments | p. 322 |
| COSY | p. 327 |
| Heteronuclear Correlation by Indirect Detection | p. 334 |
| Three- and Four-Dimensional NMR | p. 339 |
| Additional Reading and Resources | p. 345 |
| Problems | p. 346 |
| Elucidation of Molecular Structure and Macromolecular Conformation | |
| Organic Structure Elucidation | p. 348 |
| Application of Some Useful 2D Methods | p. 352 |
| Structure and Configuration of Polymers | p. 355 |
| Three-Dimensional Structure of Biopolymers | p. 358 |
| Additional Reading and Resources | p. 367 |
| NMR Imaging and Spatially Localized Spectroscopy | |
| Use of Magnetic Field Gradients to Produce Images | p. 369 |
| Use of 2D NMR Methods in Imaging | p. 371 |
| k Space; Echo Planar Imaging | p. 374 |
| Factors Affecting Image Contrast | p. 375 |
| Chemical Shift Imaging and in Vivo Spectroscopy | p. 378 |
| NMR Imaging in Solids | p. 379 |
| Additional Reading and Resources | p. 380 |
| Properties of Common Nuclear Spins | p. 381 |
| ABX and AA'XX' Spectra | p. 385 |
| The ABX System | p. 385 |
| The AA'XX' System | p. 389 |
| Review of Relevant Mathematics | p. 393 |
| Complex Numbers | p. 393 |
| Trigonometric Identities | p. 394 |
| Vectors | p. 394 |
| Matrices | p. 395 |
| Spin Matrices | p. 397 |
| One Spin | p. 397 |
| Two-Spin System | p. 397 |
| Selected Answers to Problems | p. 401 |
| References | p. 411 |
| Index | p. 417 |
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