Immune Interferon : Properties and Clinical Applications - Ivan Ivanov

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Immune Interferon

Properties and Clinical Applications

By: Ivan Ivanov, Roumen G. Tsanev

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Hardcover | 28 November 2001 | Edition Number 1

At a Glance

Hardcover
320 Pages

Dimensions(cm)
23.4 x 15.6 x 2.54

Hardcover

$842.25

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Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma). Immune Interferon: Properties and Clinical Applications is essential reading for anyone working with interferons.

Having developed their own brand of interferon-gamma, the authors have become well known for their research and significant contributions in the fields of molecular biology, biochemistry, and interferon-gamma. They bring together the extensive findings from years of research since the discovery of the drug. Focusing on the drug itself and not particular brands, the book presents data on the properties of interferon-gamma, experimental data on its effects in cell cultures in vitro and on animals in vivo, the role that IFN-gamma plays in different diseases, and the results of its clinical applications.

As interest in this versatile drug continues to grow, new avenues for its clinical use will continue to arise. Within a single source, Immune Interferon: Properties and Clinical Applications provides you with thorough information on all facets of interferon-gamma, from biological properties, to pharmaceutical processing, to clinical application.

Industry Reviews

"an excellent review of indications studied and under study and the outcomes of IFNg, as well as an exhaustive collection of references for these indications. A briefer overview of the preclinical and pharmacologic aspects of IFNg is provided." - James E. Talmidge, Ph.D., University of Nebraska Medical School in Doody's Notes

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You Can Find This Book In

Non-Fiction Medicine Other Branches of Medicine Pharmacology Clinical & Internal Medicine Diseases & Disorders Immunology Engineering & Technology Biochemical Engineering Biotechnology Science Biology, Life Sciences

Biochemistry Biochemical Immunology Infectious & Contagious Diseases Industrial Chemistry & Manufacturing Technologies Industrial Chemistry Pharmaceutical Technology

Characteristics, production, and biological activities of interferon gamma
Introduction	p. 3
The cytokine family	p. 5
Interferon gamma	p. 9
Differences between IFN[gamma] and IFN[alpha]/[beta]	p. 9
INF[gamma]-producing cells. Inducers and inhibitors. Effect of aging	p. 9
Structure and physicochemical properties of IFN[gamma]	p. 12
The molecule of human IFN[gamma]	p. 12
The IFN[gamma] gene	p. 16
Molecular structure and biological activity of IFN[gamma]	p. 17
IFN[gamma] receptors	p. 20
Biological activities of interferon gamma	p. 25
Antiviral activity	p. 25
Antiproliferative activity	p. 28
Immunostimulatory activity	p. 32
Modulation of gene activity	p. 34
Antibacterial activity	p. 35
Antitumor activity	p. 35
Molecular mechanisms of interferon gamma activities. Transmembrane signal transduction	p. 39
Production of interferon gamma	p. 41
Interferon gamma preparations	p. 45
IFN[gamma]-1b	p. 45
Gammaferon	p. 45
Others	p. 47
Interferon gamma in pathological processes and its clinical application
Indications and contraindications	p. 51
Routes of administration, pharmacokinetics, dosage	p. 53
Parenteral	p. 53
Sonophoresis/Phonophoresis	p. 55
Topical	p. 55
Inhalation	p. 56
Liposomes	p. 57
Other methods of delivery	p. 58
Side effects	p. 59
Frequent side effects	p. 59
Rare and very rare side effects	p. 59
Infectious diseases	p. 61
Viral infections	p. 61
Herpes simplex virus type 1 and type 2 (herpes genitalis)	p. 61
Herpes zoster	p. 66
Herpetic and adenoviral eye infections	p. 67
Respiratory viral infections	p. 71
Human papillomaviruses	p. 72
Condylomata accuminata	p. 72
Laryngeal papillomas	p. 74
Common warts	p. 74
Human immunodeficiency virus infection	p. 75
Changes in cytokine profile	p. 75
Effect of different cytokines	p. 80
Hepatitis	p. 81
Nonviral intracellular pathogens	p. 83
Bacterial infections	p. 83
Mycobacteria	p. 83
Tuberculosis	p. 83
Leprosy	p. 87
Chlamydia	p. 87
Protozoa	p. 88
Leishmaniasis	p. 89
Fungi	p. 89
Nonviral extracellular pathogens	p. 89
Noninfectious nonmalignant diseases	p. 91
Fibroproliferative diseases	p. 91
Fibrosis of different tissues and organs	p. 92
Keloids	p. 92
Fibrosis of the lung	p. 92
Fibrosis of the liver	p. 94
Systemic sclerosis and scleroderma	p. 94
Atherosclerosis	p. 95
Multiple sclerosis	p. 98
Psoriasis	p. 98
Chronic granulomatous disease	p. 99
Skin ulcers in autoimmune vasculitis	p. 101
Rheumatoid arthritis	p. 101
Osteopetrosis	p. 106
Allergic disorders	p. 107
Atopic dermatitis	p. 108
Asthma	p. 109
Other allergic reactions	p. 110
Lupus erythematosus	p. 111
Severe traumas, burns, and surgical operations	p. 113
Malignant diseases	p. 115
Background for using IFNgamma in malignancies	p. 115
Basocellular skin cancer (basalioma)	p. 122
Cancer of the Larynx	p. 123
Lung cancer	p. 123
Colorectal cancer	p. 127
Malignant melanoma	p. 130
Renal cell carcinoma (RCC)	p. 136
Breast cancer	p. 141
Cervical cancer	p. 145
Gastric cancer	p. 148
Prostate cancer	p. 149
Ovarian cancer	p. 150
Cancer of the bladder	p. 152
Hepatocellular carcinoma	p. 153
Sarcomas	p. 156
Kaposi's sarcoma	p. 157
Neuroblastoma	p. 158
Gliomas/glyoblastomas	p. 160
Hematological malignancies	p. 161
Chronic myelogenous leukemia	p. 161
B and T chronic lymphatic leukemias	p. 164
Acute leukemias	p. 164
Lymphomas	p. 168
Myelodysplastic syndrome (MDS)	p. 169
Multiple myeloma (MM)	p. 169
Conclusions on the use of IFNgamma in malignant diseases	p. 171
General conclusions	p. 175
References	p. 177
Index	p. 295
Table of Contents provided by Syndetics. All Rights Reserved.

Immune Interferon

Properties and Clinical Applications

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

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