Inhibitors of the Ras Superfamily G-Proteins

*The Ras superfamily G-proteins Fuyuhiko Tamanoi*NMR Study to Identify a Ligand-Binding Pocket in Ras Till Maurer and Weiru Wang*The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules Christian W. Johnson and Carla Mattos*State 1(T) Inhibitors of Activated Ras Hans Robert Kalbitzer and Michael Spoerner*Sugar-Based Inhibitors of Ras Activation: Biological Activity and Identification of Ras-Inhibitor Binding Interface Alessandro Di Domizio and Francesco Peri *Development of EHop-016, a Small Molecule Inhibitor of Rac Suranganie Dharmawardhane *Aptamer-Derived Peptide Inhibitors of Rho Guanine Nucleotide Exchange Factors Susanne Schmidt and Anne Debant*Targeting the Dbl and Dock-Family RhoGEFs: a Yeast-Based Assay to Identify Cell-Active Inhibitors of Rho-Controlled Pathways Anne Blangy and Philippe Fort*Inhibitors of the ROCK Serine/Threonine Kinases: Key Effectors of the RhoA Small GTPase Dominico Vigil and Channing J. Der*A Two-Hybrid Approach to Identify Inhibitors of the RAS-RAF Interaction Vladimir Khazak, Susanne Eyrisch, Juran Kato, Fuyuhiko Tamanoi and Erica A. Golemis *Inhibitors of K-Ras Plasma Membrane Localization Kwang-jin Cho, Dharini van der Hoeven and John F. Hancock *Ras Chaperons: New Targets for Cancer and Immunotherapy Yoel Kloog, Galit Elad-Sfadia, Roni Haklai and Adam Mor