| Introduction to Ion Mobility Spectrometry | |
| Background | |
| Methods of Ion Mobility Spectrometry | |
| Emerging Patterns in the Development of Ion Mobility Methods Summary Comments | |
| History of Ion Mobility Spectrometry | |
| Introduction | |
| The Formative Years of Discovery (1895 to 1960) | |
| Ion Mobility Spectrometry for Chemical Measurements (1960 to 1990) Mobility Methods beyond Military and Security Venues (1990 to 2000) Commercial Production of Mobility-Based Analyzers (2000 to Present) The Society for Ion Mobility Spectrometry and Journal | |
| Sample Introduction Methods | |
| Introduction | |
| Vapor Samples | |
| Semivolatile Samples | |
| Aqueous Samples | |
| Solid Samples | |
| Summary | |
| Ion Sources | |
| Introduction | |
| Radioactivity: Nickel, Americium, and Tritium | |
| Corona Discharges | |
| Photoionization: Discharge Lamps and Lasers | |
| Electrospray Ionization and Its Derivatives | |
| Matrix-Assisted Laser Desorption Ionization | |
| Surface Ionization Sources | |
| Flames | |
| Plasma-Based Ion Sources | |
| Glow Discharge Ion Source | |
| Other Ion Sources | |
| Summary | |
| Appendix | |
| Ion Injection and Pulsed Sources | |
| Introduction | |
| Operation and Structures of Ion Shutters | |
| Models and Modes of Operation | |
| Ion Injection to Drift Regions without Wire-Based Ion Shutters Mobility Methods with Continuous Flow of Ions into the Drift Region Summary and Conclusions | |
| Drift Tubes in Ion Mobility Spectrometry | |
| Introduction | |
| Traditional Drift Tubes with Stacked-Ring Designs | |
| High Field Asymmetric Drift Tubes | |
| Aspirator Drift Tubes | |
| Traveling Wave Drift Tubes | |
| Tandem Mobility Spectrometers | |
| Other Drift Tube Designs | |
| Selection of Materials | |
| Summary and Conclusions | |
| Ion Detectors | |
| Introduction | |
| Ambient Detection of Mobility-Separated Ions | |
| Low-Pressure Detection of Mobility-Separated Ions | |
| Summary | |
| The Ion Mobility Spectrum | |
| Introduction | |
| Mobility, Electric Field, and Pressure | |
| Ion Mobility Spectra | |
| IMS as a Separation Device | |
| Quantitative Aspects to Response | |
| Summary | |
| Ion Mobility-Mass Spectrometry | |
| Combining Mobility with Mass | |
| Low-Pressure Drift Tube Ion Mobility Spectrometry-Mass Spectrometry Atmospheric Pressure Drift Tube Ion Mobility Mass Spectrometry Differential Mobility Spectrometry-Mass Spectrometry | |
| Aspiration Ion Mobility Spectrometry-Mass Spectrometry | |
| Ion Mobility MS and the Future | |
| Ion Characterization and Separation: Mobility of Gas PhaseIons in Electric Fields | |
| Introduction | |
| Motion of Slow Ions in Gases | |
| Models for Ion-Neutral Interactions | |
| Linear Ion Mobility Spectrometers: Models and Experimental Evidence | |
| Differential Mobility Spectrometer and the Dependence of Ion Mobility on the Electric Field Strength | |
| Traveling Wave IMS | |
| Summary | |
| Control and Effects of Experimental Parameters | |
| Introduction | |
| Chemical Composition of the Support Gas Atmosphere | |
| Moisture and Temperature of the Supporting Gas Atmosphere | |
| Effects of Pressure | |
| Effects of Field Strength and Ion Residence Time | |
| Effects of Analyte Concentration | |
| Summary | |
| Detection of Explosives by IMS | |
| General Comments on Detection of Explosives | |
| The Chemistry Underlying Detection of Explosives by IMS | |
| Sampling and Preconcentration Techniques for Detection of Explosives | |
| Measurement with Handheld Devices, Portable Instruments, and Portals | |
| Research and Operational Experience | |
| Walk-Through Portals and Systems for Luggage Screening | |
| Homemade and Alternate Explosives | |
| Standards for Calibration of Explosive Detectors | |
| Database for Explosives | |
| Chemical Weapons | |
| Introduction and General Comments on Detection of Chemical Warfare Agents | |
| The Ion Chemistry Underlying Detection of Chemical Weapons | |
| Sampling and Preconcentration Techniques | |
| Research, Operational Experience, and Historical Perspective of Instrumentation | |
| State-of-the-Art Commercial Instruments, Standards, and Calibration | |
| Summary | |
| Drugs of Abuse | |
| Introduction and General Comments on Detection of Drugs | |
| The Ion Chemistry Underlying Detection of Drugs | |
| Sampling and Preconcentration Techniques | |
| Research, Operational Experience, and Instrumentation | |
| Standards and Calibration | |
| Database for Drugs | |
| Pharmaceuticals | |
| Introduction | |
| Compound Identification | |
| Formulation Validation | |
| Cleaning Validation | |
| Reaction Monitoring | |
| Monitoring Biological Samples | |
| Summary and Conclusion | |
| Industrial Applications | |
| Introduction | |
| Industrial Processes | |
| Industrial Feedstock or Products | |
| Food Production | |
| Conclusions | |
| Environmental Monitoring | |
| Introduction | |
| Airborne Vapors | |
| Water | |
| Soil | |
| Conclusions | |
| Biological and Medical Applications of IMS | |
| Introduction and General Comments on Biological and Medical Applications | |
| Medical Diagnostics Using IMS | |
| Food Freshness, Molds, and Odor Detection | |
| Macromolecules: Biomolecules and Biopolymers | |
| Detection and Determination of Bacteria | |
| Other Biological Applications | |
| Conclusion | |
| Current Assessments and Future Developments in Ion Mobility Spectrometry | |
| State of the Science and Technology of IMS | |
| Next Generation in Ion Mobility Methods | |
| Directions for IMS | |
| Final Thoughts | |
| Table of Contents provided by Publisher. All Rights Reserved. |
