Joint Replacement and Bone Resorption
Pathology, Biomaterials and Clinical Practice
By: Arun Shanbhag (Editor), Harry E. Rubash (Editor), Joshua J. Jacobs (Editor)
Hardcover | 9 November 2005 | Edition Number 1
At a Glance
822 Pages
22.86 x 15.24 x 4.29
Hardcover
RRP $431.00
$304.95
29%OFF
or 4 interest-free payments of $76.24 with
orAims to ship in 7 to 10 business days
When will this arrive by?
Enter delivery postcode to estimate
Foreword | p. v |
Foreword | p. vii |
Preface | p. xi |
Contributors | p. xxvii |
Clinical Picture | |
Periprosthetic Osteolysis Around Total Hips and Total Knees | p. 1 |
References | p. 8 |
Fixation of Implants | p. 13 |
Introduction | p. 13 |
Definitions | p. 14 |
Bone Ingrowth and Fracture Healing | p. 14 |
Surgically Induced Injury and the Biological Response | p. 14 |
Implant Stability and Micromotion | p. 17 |
Pore Size | p. 18 |
Interface Gaps | p. 19 |
Factors Known to Inhibit Cementless Fixation | p. 20 |
Clinical Behavior of Cementless Fixation | p. 21 |
Animal Studies | p. 25 |
Retrieval Studies | p. 27 |
Conclusion | p. 35 |
References | p. 36 |
Fixation of Implants with Bone Cement | p. 53 |
Introduction to the Use of Polymethylmethacrylate as Bone Cement | p. 53 |
Disadvantages of PMMA Bone Cement and Resultant Issues for Clinical Use | p. 54 |
Question of the Gold Standard | p. 60 |
References | p. 61 |
Total Hip Replacement: Incidence of Osteolysis and Clinical Presentation | p. 63 |
Introduction | p. 63 |
Incidence | p. 65 |
Diagnosis and Clinical Symptoms | p. 71 |
Radiographic Appearance | p. 72 |
References | p. 79 |
Total Knee Arthroplasty: Incidence of Osteolysis and Clinical Presentation | p. 89 |
Introduction | p. 89 |
Incidence | p. 90 |
Clinical Presentation | p. 91 |
Radiographic Evaluation | p. 93 |
Other Imaging Studies | p. 97 |
Laboratory Evaluation | p. 98 |
Treatment | p. 100 |
Summary | p. 101 |
References | p. 101 |
Histopathology of Periprosthetic Tissues | p. 105 |
Introduction | p. 105 |
Histopathology of Well-Fixed Joint Replacements | p. 105 |
Histopathology of Loose Joint Replacements | p. 110 |
Improving Osseointegration and Longevity of Joint Replacements: The Future | p. 115 |
References | p. 116 |
Basic Science | |
Properties of Biomaterials Used in Joint Replacements | p. 123 |
Introduction | p. 123 |
Metallic Alloys | p. 124 |
Polymers | p. 130 |
Ceramics | p. 136 |
Summary | p. 139 |
References | p. 140 |
Wear of Joint Replacements | p. 145 |
Introduction | p. 145 |
Lubrication, Friction, and Wear | p. 146 |
Basic Mechanisms, Types of Wear and Debris Generation | p. 148 |
Basic Laws of Wear and Factors that Influence Wear Rates | p. 154 |
Wear of Polyethylene in Hip Prostheses | p. 155 |
Wear of Stabilized and Cross-Linked Polyethylene in Hip Prostheses | p. 159 |
Wear of Ceramic-Ceramic Hips | p. 161 |
Wear of Metal-Metal Hips | p. 162 |
Wear of Polyethylene in Knee Prostheses | p. 162 |
Future Perspectives-Bearing Surfaces and Reduction in Wear | p. 164 |
References | p. 165 |
Human Motion and Its Relevance to Wear and Failure in Total Knee Arthroplasty | p. 777 |
Introduction | p. 171 |
The System Approach of Tribology | p. 172 |
Evolution of Knee Prosthesis Design | p. 174 |
Functional Knee Joint Kinematics and Kinetics | p. 175 |
Estimation of Contact Forces | p. 184 |
Fatigue and Wear Due to Tractive Forces | p. 192 |
State-of-the-Art Knee Wear Testing | p. 199 |
Conclusions | p. 201 |
Appendix | p. 202 |
References | p. 203 |
Corrosion of Metallic Implants | p. 211 |
Introduction | p. 211 |
General Corrosion Concept | p. 212 |
In Vitro Corrosion Testing Methods | p. 218 |
Corrosion of Orthopaedic Alloys | p. 223 |
Metal Release | p. 233 |
Local Tissue Effects | p. 237 |
Remote and Systemic Effects | p. 239 |
Future Directions and Conclusions | p. 246 |
References | p. 247 |
Inflammation and the Role of Macrophages in the Foreign Body Reaction | p. 255 |
Introduction | p. 255 |
Early, Transient Tissue/Material Responses | p. 256 |
Late, Persistent Tissue Responses | p. 265 |
Future Perspectives | p. 275 |
References | p. 276 |
Cytokines and Mediators in Physiologic and Pathologic Bone Resorption | p. 281 |
Introduction | p. 281 |
Factors Regulating Peri-implant Osteoclast Formation | p. 288 |
Peri-implant Factors Which Influence Osteolytic Mediators | p. 301 |
Summary and Overview | p. 306 |
References | p. 308 |
Mechanisms of Peri-Implant Bone Loss | |
Wear Debris Mediated Osteolysis: An Overview | p. 327 |
Introduction | p. 327 |
Historical Perspective | p. 328 |
Analysis of Clinical Material | p. 330 |
Types of Wear Debris Involved in Osteolysis | p. 331 |
In Vitro Evidence of Wear Mediated Osteolysis | p. 333 |
In Vivo Models for Osteolysis | p. 336 |
Summary | p. 338 |
References | p. 338 |
Role of the Immune Response in Implant Loosening | p. 345 |
Introduction | p. 345 |
The Normal Immune Response | p. 346 |
Hypersensitivity-The Allergic Response | p. 350 |
Effects of Polymers on the Immune Response | p. 353 |
Immune Response to Metals | p. 356 |
Immune Response to Bone | p. 358 |
The Immune Response in Clinical Practice | p. 363 |
Summary | p. 368 |
References | p. 368 |
Stress-Related Bone Resorption | p. 375 |
Introduction | p. 375 |
Bone Resorption in the Hip-Femur | p. 377 |
Bone Resorption in the Hip-Acetabulum | p. 385 |
Bone Resorption in the Knee-Femur | p. 387 |
Bone Resorption in the Knee-Tibia | p. 388 |
Discussion and Conclusions | p. 390 |
References | p. 392 |
Pressure- and Motion-Induced Factors in Implant Loosening | p. 399 |
Introduction: A Lesson from the Dentists | p. 399 |
Early Migration Predicts Late Loosening | p. 400 |
When Initial Fixation Is Lost, Secondary Resorptive Stimuli Appear | p. 402 |
Particles Appear Less Important than Pressure and Instability | p. 406 |
Early Loss of Fixation Theory Implies New Means to Prevent Loosening | p. 407 |
References | p. 408 |
Role of Endotoxin in Implant Loosening | p. 413 |
Introduction | p. 413 |
Basic Science of LPS | p. 413 |
Role of LPS in Particle-Induced Osteolysis | p. 415 |
Effects of LPS on Particle-Cell Interactions In Vitro | p. 416 |
LPS in Clinical Osteolysis | p. 421 |
Summary | p. 423 |
References | p. 424 |
Signal Transduction and Gene Regulation in Cell-Material Interactions | p. 429 |
Introduction | p. 429 |
Intracellular Signal Transduction | p. 430 |
NF-[kappa]B/Rel Transcription Factor Family | p. 431 |
AP-1 Transcription Factor Family | p. 433 |
NF-IL6 Transcription Factor Family | p. 435 |
STAT Transcription Factor Family | p. 435 |
MAP Kinase Signaling Pathways | p. 437 |
Particle-Induced Signal Transduction | p. 438 |
Signaling Mechanisms: Particle Phagocytosis vs. Redox-Regulation | p. 440 |
Redox Mechanisms in Particle-Mediated Signaling | p. 443 |
Conclusions and Future Directions | p. 444 |
References | p. 445 |
In Vitro and In Vivo Models for Understanding Osteolysis | p. 453 |
Introduction | p. 453 |
Techniques in Analyzing Clinical Material | p. 454 |
In Vitro Models | p. 456 |
In Vivo Models | p. 463 |
Summary | p. 469 |
References | p. 470 |
Solutions and Treatments | |
Surgical Techniques: Modern Cementing Techniques | p. 479 |
Radiographic Analysis | p. 480 |
Evolution of Cement Technique | p. 482 |
Present Technique for the Insertion of Cemented Femoral Components | p. 492 |
Conclusions | p. 494 |
References | p. 494 |
Treating Hip and Pelvic Osteolysis | p. 497 |
Introduction | p. 497 |
Particle Generators | p. 498 |
Clinical Presentation | p. 498 |
Differential Diagnosis | p. 499 |
History | p. 499 |
Physical Examination | p. 501 |
Blood Tests | p. 501 |
Radiographs | p. 502 |
Cemented Femoral Components | p. 503 |
Noncemented Femoral Components | p. 505 |
Cemented Acetabular Components | p. 506 |
Noncemented Acetabular Components | p. 508 |
Radiographic Follow-Up | p. 508 |
Aspiration | p. 509 |
Intraoperative Tests | p. 509 |
Classification | p. 509 |
Femoral Defect Classification Systems | p. 512 |
Results | p. 514 |
Surgical Treatment | p. 518 |
Acetabular Osteolysis-Management | p. 518 |
Femoral Osteolysis-Management | p. 525 |
Conclusion | p. 533 |
References | p. 534 |
Managing Knee Osteolysis | p. 541 |
Introduction | p. 541 |
Pathophysiology and Natural History | p. 541 |
The Clinical Presentation of Osteolysis | p. 542 |
Prophylaxis: Anticipating and Preventing Osteolysis | p. 545 |
Management of Established Osteolysis | p. 547 |
Surgical Treatment of Osteolysis and Wear | p. 548 |
Conclusion | p. 555 |
References | p. 555 |
Advances in Metals | p. 559 |
Introduction | p. 559 |
Metal Manufacturing Processes | p. 562 |
Cobalt-Chromium Alloys | p. 568 |
Titanium and Titanium Alloys | p. 572 |
Stainless Steel Alloys | p. 574 |
Mechanical Properties | p. 577 |
Mechanical Integrity of Implants-Materials and Design Elements | p. 580 |
Porous Coatings for Bone Ingrowth | p. 582 |
Surface Treatments for Improved Wear Resistance | p. 586 |
Recent Advances in Metals | p. 587 |
Summary | p. 589 |
References | p. 589 |
Advances in Polyethylene | p. 593 |
Introduction | p. 594 |
UHMWPE Wear: HIP vs. Knee Components | p. 595 |
Polyethylene: Synthesis and Molecular Structure | p. 596 |
UHMWPE: A Hierarchy of Structures | p. 597 |
UHMWPE: The Role of Degree of Crystallinity or Density | p. 600 |
UHMWPE: Powder Morphology | p. 603 |
UHMWPE: Processing Techniques | p. 605 |
UHMWPE: The Sterilization Issue | p. 607 |
UHMWPE: Alternate Forms | p. 608 |
UHMWPE: Cross-Linking | p. 608 |
UHMWPE: Future Directions | p. 609 |
References | p. 612 |
Improving UHMWPE Using Electron Beam Irradiation | p. 619 |
Introduction | p. 619 |
Solutions to Polyethylene Oxidation and Wear | p. 620 |
Basics of Radiation Chemistry of Polyethylene | p. 622 |
Optimum Radiation Dose | p. 625 |
In Vitro Evidence in Total Hip | p. 628 |
In Vivo Evidence | p. 631 |
In Vitro Evidence in Total Knee | p. 633 |
Summary | p. 638 |
References | p. 638 |
Alternate Bearing Materials: Metal-on-Metal | p. 643 |
Introduction | p. 643 |
Frictional Torque | p. 644 |
Materials and Design Considerations | p. 644 |
Lubrication | p. 645 |
Hip Simulator Tests | p. 646 |
Retrieval Studies | p. 647 |
Second-Generation Metal-on-Metal Bearings | p. 652 |
Metal-on-Metal Wear Particles | p. 653 |
Biological Considerations | p. 654 |
Serum and Urine Ions | p. 655 |
Hypersensitivity | p. 656 |
Cancer Risk | p. 657 |
Summary | p. 657 |
References | p. 658 |
Alternate Bearing Materials: Ceramic-on-Ceramic | p. 665 |
History | p. 665 |
Biomechanics and Material Properties | p. 669 |
Biocompatibility | p. 673 |
Future Considerations and Summary | p. 683 |
References | p. 684 |
Future Perspectives | |
Tissue Engineering Alternatives to Joint Replacement | p. 687 |
Introduction | p. 687 |
Cartilage Repair Procedures: Historical Perspective | p. 688 |
Cell-Based Therapies Currently Employed in the Clinic | p. 691 |
Comparison of Results from Cartilage Repair Procedures Currently Employed in the Clinic | p. 699 |
Novel Tissue Engineering Approaches for Cartilage Repair Currently Undergoing Investigation | p. 700 |
Summary | p. 713 |
References | p. 713 |
Enhancing Cementless Fixation | p. 727 |
Introduction | p. 727 |
Cellular Environment of Fixation | p. 728 |
Use of Growth Factors | p. 734 |
Implant Surface Modification | p. 737 |
Other Enhancing Agents | p. 741 |
Conclusion | p. 742 |
References | p. 743 |
Genome Sciences in Clinical Orthopaedics | p. 755 |
Introduction | p. 755 |
Modern Genomic Techniques | p. 757 |
Understanding the Pathogenesis of Osteoarthritis | p. 763 |
Diagnosis by Gene Expression Profiling | p. 765 |
Improving Orthopaedic Implants | p. 767 |
Pharmogenomics | p. 769 |
Summary | p. 773 |
References | p. 774 |
Index | p. 779 |
Table of Contents provided by Ingram. All Rights Reserved. |
ISBN: 9780824729547
ISBN-10: 0824729544
Published: 9th November 2005
Format: Hardcover
Language: English
Number of Pages: 822
Audience: Professional and Scholarly
Publisher: Taylor & Francis Ltd
Country of Publication: US
Edition Number: 1
Dimensions (cm): 22.86 x 15.24 x 4.29
Weight (kg): 1.23
Shipping
Standard Shipping | Express Shipping | |
---|---|---|
Metro postcodes: | $9.99 | $14.95 |
Regional postcodes: | $9.99 | $14.95 |
Rural postcodes: | $9.99 | $14.95 |
How to return your order
At Booktopia, we offer hassle-free returns in accordance with our returns policy. If you wish to return an item, please get in touch with Booktopia Customer Care.
Additional postage charges may be applicable.
Defective items
If there is a problem with any of the items received for your order then the Booktopia Customer Care team is ready to assist you.
For more info please visit our Help Centre.
You Can Find This Book In
SIGNED COPY
Paperback
RRP $36.99
$33.25
OFF
Taking Charge of Adult ADHD: 2 Edition
Proven Strategies to Succeed at Work, at Home, and in Relationships
Paperback
RRP $51.99
$38.25
OFF
This product is categorised by
- Non-FictionMedicineComplementary MedicineChiropractic & Osteopathy
- Non-FictionMedicineSurgeryOrthopaedics & Fractures
- Non-FictionMedicineSurgerySurgical Techniques
- Non-FictionMedicineSurgeryGeneral Surgery
- Non-FictionMedicinePre-Clinical Medicine & Basic SciencesAnatomy
- Non-FictionMedicineMedicine in General