Mechanism in Protein Chemistry

By: Jack Kyte

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Hardcover | 1 August 1995 | Edition Number 1

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552 Pages

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29.21 x 22.86 x 3.18

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This book examines the chemical methods used to study the mechanisms of enzymatically catalyzed reactions with an emphasis on the crystallographic molecular models of active sites. The book traces the development of enzymatic mechanisms from physical organic studies of nonenzymatic catalysis through detailed examination of the specific interactions between catalytic amino acids and intermediate analogues in crystallographic molecular models. The strategies of enzymatic catalysis, such as coenzymatic assistance, approximation, strain, the use of general acid-bases, the involvement of intermediates, and conformational control, are the central topics around which the book is organized.

"The modern standard against which both graduate and reference texts will be judged". -- Paul A. Bartlett, University of California, Berkeley

"Indispensable for the serious student of enzyme catalysis and a splendid resource for investigators in the field". -- Paul D. Bayer, University of California, Los Angeles, Emeritus

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Preface
Stereo Drawings
Reaction Mechanisms	p. 1
Proton Transfer	p. 1
Nucleophilic Substitution	p. 6
Nucleophilic Addition to a Carbonyl	p. 11
Acyl Exchange	p. 17
Phosphoryl Exchange	p. 24
Formal Hydride Transfer	p. 27
One-Carbon Chemistry	p. 30
Enolates, Enols, and Enamines	p. 34
Dehydration-Hydration and Elimination-Addition	p. 42
Electrophilic Aromatic Substitution	p. 45
Concerted Reactions	p. 46
Coenzymes	p. 53
Pyridoxal Phosphate	p. 53
Thiamin Pyrophosphate	p. 62
Biotin	p. 69
Flavin	p. 72
One-Electron Transfer	p. 90
Transfer of Energy	p. 108
Coenzymes of the Metabolism of Molecular Oxygen	p. 110
Selenocysteine	p. 131
Coenzyme B[subscript 12]	p. 132
Binding of Substrates to the Active Site	p. 145
The Reaction or Reactions Catalyzed	p. 146
Steady-State Kinetics	p. 149
Binding	p. 175
Nonideal, Superstoichiometric, and Substoichiometric Behavior	p. 190
Contributions of Binding to Catalysis	p. 199
Crystallographic Studies of Active Sites	p. 214
Induced Fit	p. 233
Association of Reactants and Dissociation of Products	p. 237
Transfer of Substrates among Active Sites	p. 243
Appendix: Molecularity and Approximation	p. 251
Transfer of Protons	p. 257
General Acid Catalysis and General Base Catalysis	p. 257
Enzymatic pH-Rate Profiles	p. 271
Kinetic Isotope Effects	p. 284
Stereochemistry	p. 293
Modification and Labeling of the Active Site	p. 314
Acid-Bases in Crystallographic Molecular Models	p. 345
Metalloenzymes	p. 350
Intermediates in Enzymatic Reactions	p. 373
Chemical Identification of Intermediates	p. 375
Double Kinetic Isotope Effects	p. 412
Isotopic Exchange	p. 417
Flow Methods	p. 437
Conformational Changes	p. 461
Allosteric Control of Enzymatic Reactions	p. 465
Cooperativity	p. 473
Conformational Changes and Oligomeric Associations	p. 490
Rates of Conformational Changes	p. 495
Crystallographic Studies of Conformational Changes	p. 496
Systems for Pleiotropic Regulation	p. 500
Conformational Conversion of Energy	p. 507
Index	p. 521
Table of Contents provided by Blackwell. All Rights Reserved.

Mechanism in Protein Chemistry

At a Glance

Hardcover

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