Preface 7
Contributors 8
Abbreviations 9
How To Use Your Textbook 12
About the Companion Website 15
Part 1 Cellular Structure and Function
1 Cells 16
Sebastiaan Winkler
2 Organisation of Cell Membranes 18
Sebastiaan Winkler
3 Cell Organelles 20
Sebastiaan Winkler
4 Protein Biochemistry 22
Fergus Doherty
5 Lipid Biochemistry 24
Jane Arnold
6 Carbohydrate Biochemistry 26
Fergus Doherty
7 Basic Mechanisms of Drug Action 28
Michael D Randall
Part 2 Cellular Metabolism
8 General Principles of Cellular Metabolism 30
Fergus Doherty
9 Enzymes 32
Michael D Randall
10 Central Metabolic Pathways 34
Fergus Doherty
11 Fat Metabolism 36
Fergus Doherty
12 Glucose Metabolism 38
Fergus Doherty
13 Amino Acid Metabolism 40
Jane Arnold
Part 3 Molecular and Medical Genetics
14 Principles of Molecular Genetics 42
Stuart Brown
15 DNA and RNA 44
Stuart Brown
16 Gene Expression 46
Stuart Brown
17 Medical Genetics 48
Stuart Brown
Part 4 Nerve and Muscle
18 Cell Excitability 50
Michael D Randall
19 Nervous Conduction 52
Michael D Randall
20 Synaptic Transmission 54
Michael D Randall
21 Autonomic Nervous System 56
Michael D Randall
22 Neuromuscular Transmission 58
Michael D Randall
Part 5 Respiratory System
23 Structure of the Respiratory System 60
Siobhan Loughna and Deborah Merrick
24 Respiratory Physiology 62
Steven Burr
25 Gas Transport 64
Steven Burr
26 Control of Breathing 66
Steven Burr
27 Acid-Base Physiology 68
Steven Burr
28 Respiratory Pathophysiology 70
Steven Burr
Part 6 Cardiovascular System
29 Structure of the Cardiovascular System 72
Siobhan Loughna and Deborah Merrick
30 Cardiac Physiology 74
Michael D Randall
31 Cardiovascular Physiology 76
Michael D Randall
32 Blood Pressure 78
Michael D Randall
33 Blood: 1 80
Michael D Randall
34 Blood: 2 82
Michael D Randall
35 Cardiovascular Pathophysiology 84
Michael D Randall
Part 7 Renal System
36 Structure of the Renal System 86
Deborah Merrick
37 Renal Physiology: Filtration and Tubular Function 88
Sue Chan
38 Renal Physiology: Loop of Henle 90
Sue Chan
39 Regulation of Body Fluids 92
Sue Chan
40 Bladder Function and Dysfunction 94
Michael D Randall
Part 8 Digestive System
41 Structure of the Gastrointestinal System 96
Deborah Merrick
42 Upper Gastrointestinal Physiology 98
Michael D Randall
43 Lower Gastrointestinal Physiology 100
Michael D Randall
44 The Liver 102
Michael D Randall
Part 9 Endocrine System
45 Hypothalamus and Pituitary 104
Sue Chan
46 Endocrine Pancreas 106
Sue Chan
47 Thyroid Gland 108
Sue Chan
48 Adrenal Glands and Steroid Hormones 110
Sue Chan
Part 10 Reproductive Function
49 The Genital System 112
Deborah Merrick
50 Reproductive Physiology 114
Michael D Randall
51 Human Embryology 116
Deborah Merrick
Part 11 Central Nervous System
52 Structure of the Central Nervous System 118
Deborah Merrick
53 The Sensory System 120
Deborah Merrick
54 The Motor System 122
Deborah Merrick
55 Hypothalamus and Thalamus 124
Deborah Merrick
56 Central Nervous System Function 126
Michael D Randall
57 CNS Disorders and Treatments 128
Michael D Randall
Part 12 Infections and Immunity
58 Pathogens 130
James Lazenby And Chien-Yi Chang
59 Recognition of Pathogens 134
Lucy Fairclough and Ian Todd
60 Defence Against Pathogens 136
Lucy Fairclough and Ian Todd
61 Integration of the Immune Response 138
Lucy Fairclough and Ian Todd
62 Immunopathology 140
Ian Todd and Lucy Fairclough
63 Immunodeficiency Disorders 142
Ian Todd and Lucy Fairclough
Part 13 Cancer
64 Cancer 145
Stuart Brown
65 Chemotherapy 148
Michael D Randall
Appendix 1 Cross References to Medicine at a Glance (Davey) 150
Index 154