Membrane Receptors, Channels and Transporters in Pulmonary Circulation

Part I Ion Channels in the Pulmonary Vasculature: Basics and New Findings The Role of Ion Channels in Hypoxic Pulmonary Vasoconstriction E. Kenneth Weir, Jesus A. Cabrera, Saswati Mahapatra, Douglas A. Peterson, and Zhigang Hong Two-Pore Domain K+ Channels and Their Role in Chemoreception Keith J. Buckler Intricate Interaction Between Store-Operated Calcium Entry and Calcium-Activated Chloride Channels in Pulmonary Artery Smooth Muscle Cells Abigail S. Forrest, Jeff E. Angermann, Rajesh Raghunathan, Catherine Lachendro, Iain A. Greenwood, and Normand Leblanc The Role of Intracellular Ion Channels in Regulating Cytoplasmic Calciumin Pulmonary Arterial Mmooth Muscle: Which Store and Where? A. Mark Evans Ca2+ Oscillations Regulate Contraction Of Intrapulmonary Smooth Muscle Cells Michael J. Sanderson, Yan Bai, and Jose Perez-Zoghbi Part II TRP Channels in the Pulmonary Vasculature:Basics and New Findings Introduction to TRP Channels: Structure, Function, and Regulation Michael Y. Song and Jason X.-J. Yuan Physiological Functions of Transient Receptor Potential Channels in Pulmonary Arterial Smooth Muscle Cells Xiao-Ru Yang, Mo-Jun Lin, and James S. K. Sham The Contribution of TRPC1 and STIM1 to Capacitative Ca2+ Entry in Pulmonary Artery Lih Chyuan Ng, Judith A. Airey, and Joseph R. Hume Store-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1 Donna L. Cioffi, Christina Barry, and Troy Stevens TRPM2 Channel Regulates Endothelial Barrier Function Claudie M. Hecquet, Gias U. Ahmmed, and Asrar B. Malik Part III Pathogenic Role of Ion Channels in Pulmonary Vascular Disease A Proposed Mitochondrial--Metabolic Mechanism for Initiation and Maintenance of Pulmonary Arterial Hypertension in Fawn-Hooded Rats: The Warburg Model of Pulmonary Arterial Hypertension Jalees Rehman and Stephen L. Archer The Role of Classical Transient Receptor Potential Channels in the Regulation of Hypoxic Pulmonary Vasoconstriction B. Fuchs, A. Dietrich, T. Gudermann, H. Kalwa, F. Grimminger, and N. Weissmann Developmental Regulation of Oxygen Sensing and Ion Channels in the Pulmonary Vasculature David N. Cornfield Hypoxic Regulation of Ion Channels and Transporters in Pulmonary Vascular Smooth Muscle Larissa A. Shimoda CLC-3 Chloride Channels in the Pulmonary Vasculature Joseph R. Hume, Ge-Xin Wang, Jun Yamazaki, Lih Chyuan Ng, and Dayue Duan Part IV Receptors and Signaling Cascades in Pulmonary Arterial Hypertension Role of Bone Morphogenetic Protein Receptors in the Development of Pulmonary Arterial Hypertension Nicholas W. Morrell Cross Talk Between Smad, MAPK, and Actin in the Etiology of Pulmonary Arterial Hypertension James West Notch Signaling in Pulmonary Hypertension Patricia A. Thistlethwaite, Xiaodong Li, and Xiaoxue Zhang Rho Kinase-Mediated Vasoconstriction in Pulmonary Hypertension Ivan F. McMurtry, Kohtaro Abe, Hiroki Ota, Karen A. Fagan, and Masahiko Oka The Serotonin Hypothesis of Pulmonary Hypertension Revisited Margaret R. MacLean and Yvonne Dempsie Impaired Vascular Endothelial Growth Factor Signaling in the Pathogenesis of Neonatal Pulmonary Vascular Disease Steven H. Abman Part V Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction Mitochondrial Regulation of Oxygen Sensing Navdeep S. Chandel Reactive Oxygen Species and RhoA Signaling in Vascular Smooth Muscle: Role in Chronic Hypoxia-Induced Pulmonary Hypertension Thomas C. Resta, Brad R. S. Broughton, and Nikki L. Jernigan Polyamine Regulatory Pathways as Pharmacologic Targets in Pulmonary Arterial Hypertension Mark N. Gillespie, and Jack W. Olson 5-HT Receptors and KV Channel Internalization Angel Cogolludo and Francisco Perez-Vizcaino Part VI Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease KCNQ Potassium Channels: New Targets for Pulmonary Vasodilator Drugs? Alison M. Gurney, Shreena Joshi, and Boris Manoury Receptor Tyrosine Kinase Inhibitors in Rodent Pulmonary Hypertension Liliana Moreno-Vinasco and Joe G. N. Garcia PDGF Receptor and its Antagonists: Role in Treatment of PAH Friedrich Grimminger and Ralph Theo Schermuly PPARg and the Pathobiology of Pulmonary Arterial Hypertension Marlene Rabinovitch Targeting TASK-1 Channels as a Therapeutic Approach Andrea Olschewski Pharmacological Targets for Pulmonary Vascular Disease: Vasodilation versus Anti-Remodelling Matthew Thomas Index