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Merritt's Neurology
14th Edition
By: Elan D. Louis, Stephen Mayer, James Noble
Hardcover | 16 July 2021 | Edition Number 14
At a Glance
1718 Pages
Revised
28 x 22 x 6
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For more than 60 years, Merritt’s Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today’s practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.
- Contains more than 150 succinct chapters that offer essential information on signs and symptoms, diagnostic tests, and neurologic disorders of all etiologies.
- Includes a new section on the global burden of neurological disease, coverage of neurological implications of COVID-19, and new chapters covering:
- Addiction
- Sepsis associated encephalopathy
- New treatment modalities of previously incurable disorders, including inherited neuromuscular diseases
- New treatments with improved efficacy and tolerability in acute stroke and multiple sclerosis, among others
- Incorporation of new emerging and established biomarkers into practice
- Helps you quickly navigate the text and easily visualize neurologic topics with a vivid, highly illustrated, full-color format throughout. Many figures and tables have been incorporated throughout the text for quick reference.
- Electronic versions of the book will feature a series of new “Need to Know Neurology” video clips that focus on key take-home messages.
- The textbook can also be bundled with Merritt’s Neurology Board Review, a forthcoming companion book with over 500 sample board review questions and answers.
- Read directly on your preferred device(s), such as computer, tablet, or smartphone.
- Easily convert to audiobook, powering your content with natural language text-to-speech.
About the Author
Elan D. Louis MD, MS Professor of Neurology Linda and Mitch Hart Distinguished Chair in Neurology Chairman, Department of Neurology University of Texas Southwestern Medical Center Dallas, Texas
Stephan A. Mayer MD Director of Neurocritical Care and Emergency Neurological Services Westchester Medical Center Health Network Professor of Neurology and Neurosurgery New York Medical College Valhalla, New York
James M. Noble MD, MS, CPH, FAAN Associate Professor of Neurology at CUIMC Taub Institute for Research on Alzheimer’s Disease and the Aging Brain G.H. Sergievsky Center Department of Neurology Columbia University Irving Medical Center Columbia University Vagelos College of Physicians and Surgeons NewYork-Presbyterian Hospital New York, New York
- Contents
- SECTION I
- GLOBAL BURDEN OF NEUROLOGIC DISEASE 1
- Section Editor: Mitchell S. V. Elkind
- 1 Worldwide Epidemiology of Neurologic Disease 1
- Jennifer Sevush-Garcy and Mitchell S. V. Elkind
- 2 Global Delivery of Neurologic Care 9
- Hiral Shah, Serena Spudich, and Kiran T. Thakur
- SECTION II
- APPROACH TO THE NEUROLOGIC PATIENT 15
- Section Editor: James M. Noble
- 3 Neurologic History Taking, Localization, and Differential
- Diagnosis 15
- James M. Noble
- 4 The Neurologic Examination 25
- James M. Noble
- SECTION III
- COMMON PROBLEMS IN NEUROLOGY 45
- Section Editor: J. Kirk Roberts
- 5 Dizziness, Vertigo, and Hearing Loss 45
- J. Kirk Roberts
- 6 Syncope 51
- Tina T. Shih
- 7 Seizures 57
- Michelle Bell, David J. Roh, and Jan Claassen
- 8 Pain, Numbness, and Paresthesias 64
- Comana M. Cioroiu
- 9 Headache and Facial Pain 70
- Ashhar S. Ali and Julio R. Vieira
- 10 Visual Disturbances 77
- Heather E. Moss
- 11 Delirium 88
- Merrick E. Miles, Christina J. Hayhurst, and
- Christopher G. Hughes
- 12 Dementia and Memory Loss 95
- Lawrence S. Honig and James M. Noble
- 13 Involuntary Movements 103
- Sara M. Schaefer and Elan D. Louis
- 14 Muscle Weakness, Cramps, and Stiffness 110
- Comana M. Cioroiu
- 15 Gait Disorders 122
- Ashwini K. Rao
- 16 Acute Stroke: The First Hour 132
- Barry M. Czeisler and Stephan A. Mayer
- 17 Acute Spinal Cord Syndromes 145
- Natalie Weathered and Noam Y. Harel
- 18 Focal Mass Lesions 152
- Michelle Bell, Alexander G. Khandji, and Fabio M. Iwamoto
- 19 Stupor and Coma 168
- Jan Claassen and John C. M. Brust
- 20 Brain Death 179
- Eelco F. M. Wijdicks
- SECTION IV
- DIAGNOSTIC TESTS 184
- Section Editor: James M. Noble
- 21 Computed Tomography 184
- Priya Shoor, Daniel S. Chow, and Angela Lignelli
- 22 Magnetic Resonance Imaging 189
- Eric Newman and Angela Lignelli
- 23 Positron Emission Tomography and Single-Photon Emission
- Computed Tomography 203
- William Charles Kreisl
- 24 Neurovascular Ultrasound 208
- Tatjana Rundek
- 25 Angiography and Neuroendovascular Surgery 217
- Katarina Dakay, Scott M. Woolf, Gurmeen Kaur,
- Daniel H. Sahlein, and Fawaz Al-Mufti
- 26 Electroencephalography and Evoked Potentials 230
- Nicolas Gaspard and Emily J. Gilmore
- 27 Electromyography, Nerve Conduction Studies, and
- Magnetic Stimulation 243
- Louis H. Weimer
- 28 Autonomic Testing 255
- Louis H. Weimer
- 29 Evaluation of the Special Senses (Vision, Hearing,
- Smell, Vestibular System) 259
- J. Kirk Roberts
- 30 Sleep Studies 264
- Andrew J. Westwood and Carl W. Bazil
- 31 Neuropsychological Evaluation 271
- Yaakov Sternxxvi Contents
- 32 Lumbar Puncture and Cerebrospinal Fluid Analysis 277
- Kiwon Lee
- 33 Brain, Muscle, Nerve, and Skin Biopsy 283
- John F. Crary, Thomas H. Brannagan III, and Kurenai Tanji
- 34 Intracranial Pressure and Neurocritical Care Monitoring 288
- Charles L. Francoeur and Stephan A. Mayer
- 35 Genetic Testing and DNA Diagnosis 297
- Jill S. Goldman and Jacinda B. Sampson
- SECTION V
- CEREBROVASCULAR DISEASES 301
- Section Editor: Stephan A. Mayer
- 36 Acute Ischemic Stroke 301
- Charles C. Esenwa and Stephan A. Mayer
- 37 Transient Ischemic Attack 320
- Setareh Salehi Omran and Jose Gutierrez
- 38 Hypoxic-Ischemic Encephalopathy 324
- Sachin Agarwal and Alexandra S. Reynolds
- 39 Intracerebral Hemorrhage 332
- Stephan A. Mayer and Fred Rincon
- 40 Subarachnoid Hemorrhage 342
- Stephan A. Mayer, Gary L. Bernardini, and
- Robert A. Solomon
- 41 Cerebral Venous and Sinus Thrombosis 353
- Jennifer A. Frontera and Natalie Organek
- 42 Vascular Malformations 361
- Fawaz Al-Mufti and Stephan A. Mayer
- 43 Central Nervous System Vasculitis 370
- Kavneet Kaur, Hussein Alshammari, Ramandeep Sahni,
- Steven Marks, Stephan A. Mayer, and Fawaz Al-Mufti
- 44 Posterior Reversible Encephalopathy Syndrome and
- Other Cerebrovascular Syndromes 384
- Claire S. Riley, Sara K. Rostanski, and Joshua Z. Willey
- 45 Primary and Secondary Stroke Prevention 401
- Charles C. Esenwa and Mitchell S. V. Elkind
- SECTION VI
- NEUROTRAUMA 413
- Section Editor: Neeraj Badjatia
- 46 Concussion and Chronic Traumatic Encephalopathy 413
- James M. Noble and John F. Crary
- 47 Traumatic Brain Injury 420
- Gunjan Y. Parikh, Neeraj Badjatia, and
- Stephan A. Mayer
- 48 Traumatic Spinal Cord Injury 441
- Christopher E. Mandigo, Michael G. Kaiser, and
- Peter D. Angevine
- 49 Traumatic Cranial and Peripheral Nerve Injury 451
- Dominique M. O. Higgins, Lillian Liao,
- and Christopher J. Winfree
- SECTION VII
- DEMENTIA 469
- Section Editor: Karen S. Marder
- 50 Mild Cognitive Impairment 469
- Lawrence S. Honig, Arash Salardini, William Charles Kreisl,
- and James M. Noble
- 51 Alzheimer Disease 476
- Lawrence S. Honig and James M. Noble
- 52 Frontotemporal Dementia 486
- Edward D. Huey, Megan S. Barker, and Stephanie Cosentino
- 53 Lewy Body Dementias 492
- Oren Levy, Richard A. Hickman, and Karen S. Marder
- 54 Vascular Dementia and Cognitive Impairment 500
- Nikolaos Scarmeas and Adam M. Brickman
- 55 Prion Diseases 506
- Boon Lead Tee and Michael Geschwind
- SECTION VIII
- HEADACHE AND PAIN SYNDROMES 521
- Section Editor: Richard B. Lipton
- 56 Primary and Secondary Headache Disorders 521
- Peter J. Goadsby and Richard B. Lipton
- 57 Facial Pain Disorders and Painful Cranial Neuralgias 538
- Paul G. Mathew and Zahid H. Bajwa
- 58 Complex Regional Pain Syndrome 549
- Steven P. Cohen, Michael L. Weinberger, and
- Thomas H. Brannagan III
- 59 Neuropathic Pain 557
- Jeffrey Shije and Thomas H. Brannagan III
- SECTION IX
- EPILEPSY AND PAROXYSMAL DISORDERS 567
- Section Editor: Carl W. Bazil
- 60 Classification of Seizures and Epilepsy 567
- Shraddha Srinivasan and Carl W. Bazil
- 61 Management of Epilepsy 578
- Carl W. Bazil and Shraddha Srinivasan
- 62 Ménière Syndrome, Benign Paroxysmal Positional Vertigo, and
- Vestibular Neuritis 597
- Ian S. Storper
- 63 Transient Global Amnesia 602
- John C. M. Brust
- SECTION X
- CENTRAL NERVOUS SYSTEM INFECTIONS 604
- Section Editor: Karen L. Roos
- 64 Acute Bacterial Meningitis 604
- Karen L. Roos Contents xxvii
- 65 Brain, Spinal, and Epidural Abscess and Other Parameningeal
- Infections 612
- Tracey A. Cho
- 66 Other Bacterial Central Nervous System Infections
- and Toxins 624
- Kyle J. Coleman
- 67 Chronic Meningitis 640
- Prashanth S. Ramachandran, Joseph R. Zunt,
- Kelly J. Baldwin, and Michael R. Wilson
- 68 Parasitic Infections 653
- Gustavo C. Román
- 69 Viral Infections 661
- Shibani S. Mukerji, Maria Martinez-Lage, and
- Kiran T. Thakur
- 70 Human Immunodeficiency Virus (HIV) and Acquired
- Immunodefciency Syndrome (AIDS) 690
- Anne Damian Yacoub, Deanna Saylor, Ned Sacktor,
- Kiran T. Thakur, Carolyn Barley Britton, and
- Barbara S. Koppel
- SECTION XI
- DEMYELINATING AND INFLAMMATORY
- DISEASES 711
- Section Editor: David A. Ha? er
- 71 Multiple Sclerosis and Related CNS
- Neuroimmune Diseases 711
- Erin E. Longbrake and Sarah F. Wesley
- 72 Transverse Myelitis 736
- Eoin P. Flanagan and Brian G. Weinshenker
- 73 Neuromyelitis Optica Spectrum Disorder 744
- Iris Vanessa Marin Collazo and Brian G. Weinshenker
- 74 Autoimmune Encephalitis and Meningitis 755
- Andrew McKeon, Divyanshu Dubey, Eoin P. Flanagan,
- Anastasia Zekeridou, and Sean J. Pittock
- 75 Neurosarcoidosis 773
- Siddharama Pawate and Barney J. Stern
- SECTION XII
- MOVEMENT DISORDERS 778
- Section Editor: Elan D. Louis
- 76 Essential Tremor 778
- Elan D. Louis
- 77 Tics and Tourette Syndrome 784
- Harvey S. Singer
- 78 Restless Legs Syndrome 793
- Brian B. Koo
- 79 The Dystonias 800
- Hyder A. Jinnah
- 80 Hemifacial Spasm 820
- Paul Greene
- 81 Myoclonus 824
- Pichet Termsarasab and Steven J. Frucht
- 82 Hereditary and Acquired Ataxias 831
- Sheng-Han Kuo and Vikram G. Shakkottai
- 83 Tardive Dyskinesia and Other Neuroleptic-Induced
- Syndromes 849
- Un Jung Kang and Stanley Fahn
- 84 Choreas 854
- Ruth H. Walker and Joseph Jankovic
- 85 Huntington Disease 861
- Karen S. Marder and Richard A. Hickman
- 86 Parkinson Disease 871
- Peter LeWitt
- 87 Parkinson-Plus Syndromes 893
- Paul Greene
- SECTION XIII
- NEUROMUSCULAR DISEASES 904
- Section Editor: Thomas H. Brannagan III
- 88 Amyotrophic Lateral Sclerosis and Motor
- Neuron Diseases 904
- Neil A. Shneider
- 89 Bell’s Palsy and Cranial Neuropathies 915
- Comana M. Cioroiu and Thomas H. Brannagan III
- 90 Mononeuropathies and Compression Neuropathies 927
- Thomas H. Brannagan III
- 91 Acquired Peripheral Neuropathies 936
- Thomas H. Brannagan III and Kurenai Tanji
- 92 Inherited Peripheral Neuropathies 955
- Chiara Pisciotta and Michael E. Shy
- 93 Myasthenia Gravis and Other Disorders of the
- Neuromuscular Junction 963
- Christina M. Ulane
- 94 Inflammatory and Autoimmune Myopathies 979
- Rebecca Traub, Kurenai Tanji, and Christina M. Ulane
- 95 Critical Illness Myopathy and Neuropathy 989
- Ahmad Riad Ramadan, Michio Hirano, and
- Louis H. Weimer
- 96 Endocrine and Toxic Myopathies 992
- Christina M. Ulane
- 97 Periodic Paralysis and Other Channelopathies 998
- Comana M. Cioroiu
- 98 Stiff Person Syndrome and Peripheral Nerve and Muscle
- Hyperexcitability 1004
- Jonathan Perk and Christina M. Ulane
- 99 Metabolic and Mitochondrial Myopathies in Adults 1011
- Michio Hirano, H. Orhan Akman, and
- Salvatore DiMauroxxviii Contents
- SECTION XIV
- NEUROONCOLOGY 1019
- Section Editor: Tobias Walbert
- 100 Gliomas 1019
- J. Ricardo McFaline-Figueroa and Patrick Y. Wen
- 101 Metastatic Tumors 1034
- Rupesh Kotecha and Minesh P. Mehta
- 102 Meningiomas 1050
- Thomas J. Kaley
- 103 Primary Central Nervous System Lymphoma 1056
- Lakshmi Nayak and Tracy T. Batchelor
- 104 Tumors of the Pituitary Gland 1064
- Pamela U. Freda, John Ausiello, and Jeffrey N. Bruce
- 105 Pineal Region Tumors 1072
- Jeffrey N. Bruce
- 106 Acoustic Neuroma and Other Skull Base Tumors 1080
- Randy S. D’Amico and Michael B. Sisti
- 107 Spinal Tumors 1089
- David Cachia, Claudio E. Tatsui, and Mark R. Gilbert
- 108 Paraneoplastic Syndromes 1100
- Erika Santos Horta and Tobias Walbert
- 109 Complications of Cancer Therapy 1106
- Jasmin Jo and David Schiff
- SECTION XV
- HYDROCEPHALUS AND CEREBRAL
- EDEMA 1114
- Section Editor: Fred Rincon
- 110 Hydrocephalus 1114
- Kumud Sharma and Fred Rincon
- 111 Brain Edema and Increased Intracranial Pressure 1127
- Stephan A. Mayer
- 112 Spontaneous Intracranial Hypotension 1139
- Kevin E. Immanuel, Tiffany R. Chang,
- and Kiwon Lee
- SECTION XVI
- SPINAL CORD DISORDERS 1145
- Section Editor: Paul C. McCormick
- 113 Intervertebral Disk Disease and Radiculopathy 1145
- Hani Malone and Peter D. Angevine
- 114 Cervical and Lumbar Spinal Stenosis 1153
- Brian J.A. Gill and Paul C. McCormick
- 115 Acquired and Hereditary Myelopathies 1159
- Natalie Weathered and Noam Y. Harel
- SECTION XVII
- AUTONOMIC AND SLEEP DISTURBANCES 1170
- Section Editor: Louis H. Weimer
- 116 Autonomic Failure, Autonomic Neuropathy, and
- Orthostatic Intolerance 1170
- Louis H. Weimer
- 117 Paroxysmal Sympathetic Hyperactivity After Acute
- Brain Injury 1178
- Sophie Samuel and Huimahn Alex Choi
- 118 Sleep Disorders 1183
- Andrew J. Westwood and Carl W. Bazil
- SECTION XVIII
- SYSTEMIC ORGAN FUNCTION AND THE
- NERVOUS SYSTEM 1195
- Section Editor: Kiwon Lee
- 119 Heart-Brain Interactions 1195
- Shouri Lahiri and Stephan A. Mayer
- 120 Sepsis-Associated Encephalopathy 1201
- Aurélien Mazeraud, Cássia Righy, Stephan A. Mayer,
- and Tarek Sharshar
- 121 Respiratory Support for Neurologic Diseases 1207
- David B. Seder and Stephan A. Mayer
- 122 Endocrine Diseases and the Brain 1215
- Spyridoula Tsetsou and Alexandra S. Reynolds
- 123 Hematologic Diseases and the Brain 1227
- Andreas H. Kramer
- 124 Hepatic Disease and the Brain 1245
- Charles L. Francoeur and Stephan A. Mayer
- 125 Renal Disease, Electrolyte Disorders, and the
- Nervous System 1253
- J. Kirk Roberts and Stephan A. Mayer
- 126 Gastric and Genitourinary Function and the Brain 1262
- Alden Doerner Rinaldi and Charles C. Esenwa
- 127 Bone Diseases and the Central Nervous System 1270
- Roger N. Rosenberg and Alison M. Pack
- 128 Malnutrition, Malabsorption, and Vitamin De? ciencies 1277
- Rebecca Traub and Inna Kleyman
- 129 Neurologic Disease During Pregnancy 1286
- Alison M. Pack
- 130 Neurologic Complications of Organ Transplantation 1298
- Eelco F. M. Wijdicks Contents xxix
- SECTION XIX
- NEUROLOGIC TOXIDROMES 1303
- Section Editor: John C. M. Brust
- 131 Alcoholism 1303
- John C. M. Brust
- 132 Drug Intoxication and Withdrawal 1313
- John C. M. Brust
- 133 Neurotoxicology 1319
- Christopher Zammit and Stephan A. Mayer
- 134 Radiation Injury 1335
- Matthew R. Leach and Christopher Zammit
- 135 Electrical and Lightning Injury 1347
- Imad Khan and Christopher Zammit
- 136 Decompression Illness 1350
- Matthew R. Leach and Christopher Zammit
- SECTION XX
- PEDIATRIC NEUROLOGY 1355
- Section Editor: Arthur M. Mandel
- 137 Neonatal Neurology 1355
- Arthur M. Mandel
- 138 Nervous System Formation and Malformation 1366
- Gary D. Clark
- 139 Inherited Metabolic Diseases 1385
- Marc C. Patterson
- 140 Chromosomal Disorders and Disorders of DNA 1410
- Marc C. Patterson
- 141 The Floppy Infant 1417
- Maryam Oskoui, Laurent Servais, and
- Darryl C. De Vivo
- 142 Disorders of Motor and Cognitive Development 1424
- Jason B. Carmel, Toni S. Pearson, and Reet Sidhu
- 143 Autism Spectrum Disorders 1433
- Sylvie Goldman and Jennifer M. Bain
- 144 Mitochondrial Encephalomyopathies 1441
- Salvatore DiMauro, Emanuele Barca, and
- Michio Hirano
- 145 Neurocutaneous Syndromes 1456
- Marc C. Patterson
- 146 Spinal Muscular Atrophies of Childhood 1467
- Basil T. Darras, Richard S. Finkel, and Darryl C. De Vivo
- 147 Muscular Dystrophies and Congenital Myopathies 1474
- James J. Dowling, Hernan D. Gonorazky, Dimah N. Saade,
- Michael W. Lawlor, and Darryl C. De Vivo
- 148 Seizures and Epilepsies in Neonates and Children 1502
- Tristan T. Sands and M. Roberta Cilio
- 149 Pediatric Stroke 1515
- Sally M. Sultan and Robert H. Fryer
- 150 Brain Tumors in Children 1528
- James H. Garvin, Jr
- 151 Pediatric Brain Injury and Shaken Baby Syndrome 1572
- Joshua Cappell and Steven G. Kernie
- 152 Human Immunode? ciency Virus, Fetal Alcohol Syndrome,
- and Drug Effects 1579
- Claudia A. Chiriboga
- SECTION XXI
- PSYCHIATRY AND NEUROLOGY 1588
- Section Editor: David H. Strauss
- 153 Psychosis 1588
- Jacob S. Ballon and T. Scott Stroup
- 154 Mood Disorders 1596
- Andrés Barrera, Licínia Ganança, Alejandro S. Cazzulino,
- and Maria A. Oquendo
- 155 Anxiety Disorders, Posttraumatic Stress Disorder, and
- Obsessive-Compulsive Disorder 1606
- Franklin R. Schneier
- 156 Somatic Symptom Disorders 1615
- Anna L. Dickerman, Philip R. Muskin, and Vivian Liu
- SECTION XXII
- RECOVERY AND END-OF-LIFE CARE 1629
- Section Editor: Joel Stein
- 157 Neurologic Rehabilitation 1629
- Joel Stein and Heidi Schambra
- 158 End-of-Life and Palliative Care in Neurology 1636
- Tobias Walbert, Fred Rincon, and James M. Noble
- Index 1645
ISBN: 9781975141226
ISBN-10: 1975141229
Published: 16th July 2021
Format: Hardcover
Language: English
Number of Pages: 1718
Audience: Professional and Scholarly
Publisher: Wolters Kluwer Health
Country of Publication: US
Edition Number: 14
Edition Type: Revised
Dimensions (cm): 28 x 22 x 6
Weight (kg): 3.63
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