Meselson, Stahl, and the Replication of DNA

A History of "The Most Beautiful Experiment in Biology"

By: Frederic Lawrence Holmes

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Hardcover | 10 November 2001 | Edition Number 1

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Hardcover
528 Pages

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25.2 x 16.5 x 3.3

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In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.

This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment.

Industry Reviews

"Holmes has written a remarkable history of one of molecular biology's most significant experiments. His recreation of a seminal time in the development of the field is masterful and detailed, and it is exciting reading for anyone interested in how experimentation is actually done in a molecular biology laboratory." David Baltimore, president, California Institute of Technology

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You Can Find This Book In

Non-Fiction Science Biology, Life Sciences Molecular Biology Science in General History of Science Life Sciences in General Genetics excluding Medical DNA & Genome Scientific Equipment Medicine Medicine in General

Medical Equipment & Techniques Medical Laboratory Testing & Techniques Biochemistry Biographies & True Stories Biographies Science, Technology & Medicine Biographies History

Preface	p. ix
Acknowledgments	p. xi
Introduction	p. 1
The Replication Problem	p. 11
Meselson and Stahl	p. 49
Twists and Turns	p. 75
Crossing Fields: Chemical Bonds to Biological Mutants	p. 116
Dense Solutions	p. 157
The Big Machine	p. 183
Working at High Speed	p. 215
The Unseen Band	p. 272
One Discovery, Three Stories	p. 303
An Extremely Beautiful Experiment	p. 319
Centrifugal Forces	p. 352
The Subunits of Semiconservative Replication	p. 388
Images of an Experiment	p. 412
Afterword	p. 435
Abbreviations Used in Notes	p. 448
Notes	p. 449
Index	p. 497
Table of Contents provided by Syndetics. All Rights Reserved.

Meselson, Stahl, and the Replication of DNA

A History of "The Most Beautiful Experiment in Biology"

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

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