Preface to the Series | p. iii |
Preface to Volume 30 | p. v |
Contributors | p. xiii |
Contents of Previous Volumes | p. xv |
Handbook on Toxicity of Inorganic Compounds | p. xxxii |
Handbook on Metals in Clinical and Analytical Chemistry | p. xxxiii |
Free Radicals and Metalloenzymes: General Considerations | p. 1 |
Introduction: A Survey of Biologically Relevant Free Radicals | p. 2 |
Necessity of Free Radicals and Metal Ions | p. 4 |
Reactivities of Free Radicals | p. 7 |
Summary of Free Radical-Dependent Metalloenzymes | p. 11 |
Abbreviations | p. 21 |
References | p. 22 |
Peroxidases: Structure, Function, and Engineering | p. 25 |
Introduction | p. 26 |
Peroxidase Crystal Structures | p. 30 |
Peroxidase Catalytic Mechanisms | p. 48 |
Peroxidase Engineering | p. 56 |
Conclusions | p. 65 |
Abbreviations | p. 66 |
References | p. 67 |
Photosystem II | p. 77 |
Introduction | p. 78 |
Identification and Spectroscopic Studies of the Tyrosine Radicals | p. 83 |
Electron Transfer Reactions of the Tyrosine Radicals--Both O[subscript 2]-Evolving and Inhibited Photosystem II | p. 89 |
Other Radicals in Photosystem II | p. 95 |
Concluding Remarks | p. 99 |
Abbreviations | p. 100 |
References | p. 100 |
Ribonucleotide Reductase in Mammalian Systems | p. 109 |
Introduction | p. 110 |
Mammalian Ribonucleotide Reductase | p. 110 |
Herpes Simplex Virus Ribonucleotide Reductase | p. 115 |
Comparison of Amino Acid Sequences and Spectroscopic Properties for Different Species | p. 116 |
Formation, Properties, and Stability of the Fe-Tyrosyl Radical Center | p. 120 |
Inhibitors; Radical Scavengers; Iron Chelators; Specific Peptides | p. 121 |
Subunit Interaction and Electron Transfer | p. 124 |
Abbreviations | p. 125 |
References | p. 125 |
Manganese-Dependent Ribonucleotide Reduction and Overproduction of Nucleotides in Coryneform Bacteria | p. 131 |
Introduction: The Diversity of Ribonucleotide Reductase Systems | p. 132 |
Effects of Manganese Depletion in Coryneform Bacteria | p. 136 |
The Manganese-Containing Ribonucleotide Reductase of Brevibacterium ammoniagenes | p. 142 |
Distribution of Manganese Ribonucleotide Reductases | p. 153 |
Concluding Remarks--Ribonucleotide Reduction: Universal but Not Uniform | p. 156 |
Abbreviations | p. 158 |
References | p. 158 |
Prostaglandin Endoperoxide Synthases | p. 163 |
Introduction | p. 164 |
PGH Synthase Isozymes | p. 167 |
Cyclooxygenase Catalysis | p. 171 |
Peroxidase Catalysis | p. 179 |
Cyclooxygenase-Peroxidase Interrelationships | p. 184 |
PGH Synthase Structure | p. 186 |
Abbreviations | p. 192 |
References | p. 192 |
Diol Dehydrase from Clostridium Glycolicum: The Non-B[subscript 12]-Dependent Enzyme | p. 201 |
Introduction | p. 202 |
Diol Metabolism in C. glycolicum | p. 203 |
Properties of Membrane bound Diol Dehydrase from C. glycolicum | p. 206 |
Characterization of Diol Dehydrase | p. 209 |
Conclusions | p. 213 |
Abbreviations | p. 214 |
References | p. 214 |
Diol Dehydrase and Glycerol Dehydrase, Coenzyme B[subscript 12]-Dependent Isozymes | p. 217 |
Introduction | p. 218 |
Purification, Properties, and Structures | p. 219 |
Catalytic Properties and Mechanism of Action | p. 223 |
Formation of Free Radicals | p. 232 |
Inactivation and Reactivation | p. 240 |
Physiological Roles | p. 244 |
Concluding Remarks | p. 247 |
Abbreviations | p. 248 |
References | p. 249 |
Adenosylcobalamin (Vitamin B[subscript 12] Coenzyme)-Dependent Enzymes | p. 255 |
Survey of Adenosylcobalamin-Dependent Enzymes | p. 256 |
Mechanisms of the Co-C Bond Cleavage | p. 259 |
Mechanisms of the Subsequent Reactions | p. 269 |
Conclusion | p. 275 |
Abbreviations | p. 275 |
References | p. 276 |
S-Adenosylmethionine-Dependent Radical Formation in Anaerobic Systems | p. 279 |
Introduction | p. 280 |
Pyruvate Formate Lyase-Activating Enzyme | p. 280 |
Lysine 2,3-Aminomutase | p. 300 |
Anaerobic Ribonucleotide Reductase | p. 306 |
Concluding Remarks | p. 308 |
Abbreviations | p. 309 |
References | p. 309 |
The Free Radical-Coupled Copper Active Site of Galactose Oxidase | p. 315 |
Introduction | p. 316 |
Historical Survey | p. 318 |
Recent Developments | p. 322 |
Model Reactions and the Role of the Radical in Catalysis | p. 352 |
Abbreviations and Definitions | p. 356 |
References | p. 356 |
Amine Oxidases | p. 361 |
Introduction | p. 362 |
Structural Properties of Amine Oxidases | p. 365 |
Catalytic Mechanism of Amine Oxidases | p. 380 |
Biological Roles of Amine Oxidases | p. 392 |
Conclusions and Prospects | p. 395 |
Abbreviations | p. 396 |
References | p. 397 |
Bacterial Transport of and Resistance to Copper | p. 405 |
Introduction | p. 406 |
Copper in Bacterial Nutrition | p. 407 |
Copper Transport and Uptake | p. 409 |
Bacterial Systems Conferring Resistance to Excess Copper | p. 415 |
Concluding Remarks | p. 428 |
Definitions and Abbreviations | p. 429 |
References | p. 430 |
Author Index | p. 435 |
Subject Index | p. 469 |
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