| Lessons from H3, A Model Autosomal Mouse Minor Histocompatibility Locus | p. 1 |
| Minor H-Congenic Mouse Strains | p. 1 |
| The H3 Conundrum | p. 2 |
| The Advent of In Vitro Techniques | p. 4 |
| A Simple Model for the Greater H3 Complex Based on T-Cell Collaboration | p. 8 |
| Lessons Learned from H3 | p. 9 |
| Application of the Lessons Learned to Human Transplantation | p. 11 |
| Sizing Up the Set of H Genes in Mice | p. 15 |
| The Basis of Transplantation | p. 15 |
| Snell's Laws | p. 16 |
| Grafting Methodology | p. 16 |
| H-Mutation Project | p. 16 |
| Genetically-Defined Strains | p. 17 |
| Mutation Study Outcome | p. 18 |
| Hidden H Genes | p. 21 |
| Significance of Set Size | p. 23 |
| Some Personal Reflections on the History of Minor Histocompatibility Research | p. 27 |
| The Start: Minor H Antigens as Models for Tumor Antigens | p. 27 |
| The Hypothesis: Minor H Antigens are Short Processed Peptides | p. 30 |
| MHC-Binding Motifs | p. 31 |
| Conclusion | p. 34 |
| Identifying T Cell-Defined Histocompatibility Antigens by Expression Cloning | p. 37 |
| Minor Histocompatibility Antigens Identified at the Molecular Level | p. 39 |
| Expression Cloning: Identification of the H13 Antigen | p. 41 |
| Conclusion | p. 44 |
| Mitochondrially-Encoded Minor Histocompatibility Antigens | p. 47 |
| The Mouse Mta System: Discovery and Description | p. 47 |
| Other Mitochondrial Minor H Antigens: Rat MTA | p. 49 |
| Identification of the Rat MTF | p. 51 |
| Factors Influencing the Immunogenicity of Mitochondrial Minor H Antigens In Vivo and In Vitro | p. 52 |
| Processing and Presentation of Mitochondrial Peptides | p. 54 |
| The Male-Specific Minor Histocompatibility Antigen, HY | p. 59 |
| IR Gene Effects on In Vivo and In Vitro Responses to HY | p. 60 |
| HY-Specific MHC Class I and II Restricted T Cells | p. 61 |
| Tolerance to HY | p. 61 |
| Chromosomal Mapping of HY Genes | p. 62 |
| Expression Cloning of HY Genes | p. 64 |
| Conclusion | p. 66 |
| Mechanisms and Implications of Immunodominance | p. 71 |
| Definition of Immunodominance | p. 71 |
| Immunodominance In Vitro and In Vivo | p. 72 |
| Mechanisms of Immunodominance | p. 73 |
| Immunologic Role and Therapeutic Implications of Immunodominance | p. 74 |
| Human Minor Histocompatability Antigens: Towards Clinical Benefits | p. 79 |
| Human Minor H Antigens: From the Bedside to the Bench | p. 79 |
| Human Minor H Antigens: From Bench to Bedside | p. 82 |
| Conclusion | p. 83 |
| Mapping Human Minor Histocompatibility Genes | p. 87 |
| Genomics | p. 88 |
| Localizing Human Minor H Loci | p. 88 |
| Conclusion | p. 91 |
| Applicability of Matching for Minor Histocompatibility Antigens in Human Bone Marrow Transplantation | p. 97 |
| Rationale for Development of a Seven Locus Model | p. 98 |
| Further Evaluation of a Seven Locus Model | p. 98 |
| Rationale for Development of a Thirteen Locus Model | p. 100 |
| Potential Benefits of Typing and Matching | p. 101 |
| Conclusion | p. 102 |
| Genetic Linkage Analysis to Identify Minor Histocompatibility Loci Contributing to Graft Versus Host Disease | p. 105 |
| Candidate Human Minor H Genes Contributing to GVHD | p. 105 |
| Genome scan to Map GVHD Genes | p. 106 |
| Is CD31 a GVHD Gene? | p. 109 |
| Looking to the Future | p. 111 |
| Mouse Models for Graft-Versus-Host Disease | p. 113 |
| Bone Marrow Transplantation | p. 113 |
| Minor Histocompatibility Antigens and GVHD | p. 113 |
| Different Immunodominant Minor H Antigens Detected In Vitro and in GVHD | p. 113 |
| Potential Mechanisms of Immunodominance | p. 114 |
| Analysis of T-Cell Receptor Gene Usage During GVHD | p. 115 |
| TCR V[beta] CDR3 Spectratype Analysis | p. 116 |
| Donor CD4+ T-Cell Responses Have Limited V[beta] Usage | p. 119 |
| CDR3 Sequence Analysis in Reactive CD4+ T-Cell V[beta] Families | p. 120 |
| Conclusion | p. 121 |
| The Diversity and Characteristics of T-Cell Receptors Specific for Single Non-H2 Histocompatibility Antigens | p. 125 |
| Dichotomy Between Requirements for Allograft Rejection and CTL Generation | p. 126 |
| H4-Specific TCRs Expressed by CTLs | p. 127 |
| H4-Specific TCRs Expressed by Graft-Infiltrating CD8+ T Cells | p. 131 |
| HY-Specific TCR [beta] Chains | p. 134 |
| Conclusion | p. 136 |
| Infectious Tolerance with CD4 Monoclonal Antibodies: A Role for Minors in Linked Suppression | p. 141 |
| Introduction | p. 141 |
| Evidence for Dominant Tolerance Mediated by CD4 T Cells | p. 142 |
| How is Dominant Tolerance Maintained Life-Long? | p. 142 |
| How is Dominant Tolerance Achieved? | p. 142 |
| Therapeutic Application | p. 143 |
| Skin-Specific Minor Histocompatibility Antigens: A Critical Appraisal | p. 149 |
| Discovery of Putative Skin-Specific Histocompatibility Antigens | p. 149 |
| The Number and Mapping of Skn Loci | p. 150 |
| Problems with Skn Antigens | p. 151 |
| Detection and Analysis of Epidermal H Antigens | p. 153 |
| Evidence for Additional Epa Antigens | p. 155 |
| Antigens Encountered During Organ Transplantation | p. 159 |
| Evidence for Tissue-Specific Alloantigens | p. 159 |
| Identification of T Cells Recognizing Tissue-Specific MHC Alloantigens | p. 161 |
| Conventional and Tissue-Specific Minor H Antigens | p. 165 |
| Tissue-Specific Autoantigens and Utoimmunity | p. 165 |
| Conclusion | p. 166 |
| Human Tumor Antigens Recognizes by Cytolytic T Lymphocytes: Towards Vaccination | p. 171 |
| Isolation of T Cells Recognizing Human Tumor Antigens | p. 171 |
| Strategies for the Identification of Human Tumor Antigens | p. 171 |
| Nature of Human Tumor Antigens Recognized by CTLS | p. 174 |
| Antigens Resulting from Mutations | p. 177 |
| Towards Vaccination | p. 178 |
| Index | p. 183 |
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