Lessons from H3, A Model Autosomal Mouse Minor Histocompatibility Locus | p. 1 |
Minor H-Congenic Mouse Strains | p. 1 |
The H3 Conundrum | p. 2 |
The Advent of In Vitro Techniques | p. 4 |
A Simple Model for the Greater H3 Complex Based on T-Cell Collaboration | p. 8 |
Lessons Learned from H3 | p. 9 |
Application of the Lessons Learned to Human Transplantation | p. 11 |
Sizing Up the Set of H Genes in Mice | p. 15 |
The Basis of Transplantation | p. 15 |
Snell's Laws | p. 16 |
Grafting Methodology | p. 16 |
H-Mutation Project | p. 16 |
Genetically-Defined Strains | p. 17 |
Mutation Study Outcome | p. 18 |
Hidden H Genes | p. 21 |
Significance of Set Size | p. 23 |
Some Personal Reflections on the History of Minor Histocompatibility Research | p. 27 |
The Start: Minor H Antigens as Models for Tumor Antigens | p. 27 |
The Hypothesis: Minor H Antigens are Short Processed Peptides | p. 30 |
MHC-Binding Motifs | p. 31 |
Conclusion | p. 34 |
Identifying T Cell-Defined Histocompatibility Antigens by Expression Cloning | p. 37 |
Minor Histocompatibility Antigens Identified at the Molecular Level | p. 39 |
Expression Cloning: Identification of the H13 Antigen | p. 41 |
Conclusion | p. 44 |
Mitochondrially-Encoded Minor Histocompatibility Antigens | p. 47 |
The Mouse Mta System: Discovery and Description | p. 47 |
Other Mitochondrial Minor H Antigens: Rat MTA | p. 49 |
Identification of the Rat MTF | p. 51 |
Factors Influencing the Immunogenicity of Mitochondrial Minor H Antigens In Vivo and In Vitro | p. 52 |
Processing and Presentation of Mitochondrial Peptides | p. 54 |
The Male-Specific Minor Histocompatibility Antigen, HY | p. 59 |
IR Gene Effects on In Vivo and In Vitro Responses to HY | p. 60 |
HY-Specific MHC Class I and II Restricted T Cells | p. 61 |
Tolerance to HY | p. 61 |
Chromosomal Mapping of HY Genes | p. 62 |
Expression Cloning of HY Genes | p. 64 |
Conclusion | p. 66 |
Mechanisms and Implications of Immunodominance | p. 71 |
Definition of Immunodominance | p. 71 |
Immunodominance In Vitro and In Vivo | p. 72 |
Mechanisms of Immunodominance | p. 73 |
Immunologic Role and Therapeutic Implications of Immunodominance | p. 74 |
Human Minor Histocompatability Antigens: Towards Clinical Benefits | p. 79 |
Human Minor H Antigens: From the Bedside to the Bench | p. 79 |
Human Minor H Antigens: From Bench to Bedside | p. 82 |
Conclusion | p. 83 |
Mapping Human Minor Histocompatibility Genes | p. 87 |
Genomics | p. 88 |
Localizing Human Minor H Loci | p. 88 |
Conclusion | p. 91 |
Applicability of Matching for Minor Histocompatibility Antigens in Human Bone Marrow Transplantation | p. 97 |
Rationale for Development of a Seven Locus Model | p. 98 |
Further Evaluation of a Seven Locus Model | p. 98 |
Rationale for Development of a Thirteen Locus Model | p. 100 |
Potential Benefits of Typing and Matching | p. 101 |
Conclusion | p. 102 |
Genetic Linkage Analysis to Identify Minor Histocompatibility Loci Contributing to Graft Versus Host Disease | p. 105 |
Candidate Human Minor H Genes Contributing to GVHD | p. 105 |
Genome scan to Map GVHD Genes | p. 106 |
Is CD31 a GVHD Gene? | p. 109 |
Looking to the Future | p. 111 |
Mouse Models for Graft-Versus-Host Disease | p. 113 |
Bone Marrow Transplantation | p. 113 |
Minor Histocompatibility Antigens and GVHD | p. 113 |
Different Immunodominant Minor H Antigens Detected In Vitro and in GVHD | p. 113 |
Potential Mechanisms of Immunodominance | p. 114 |
Analysis of T-Cell Receptor Gene Usage During GVHD | p. 115 |
TCR V[beta] CDR3 Spectratype Analysis | p. 116 |
Donor CD4+ T-Cell Responses Have Limited V[beta] Usage | p. 119 |
CDR3 Sequence Analysis in Reactive CD4+ T-Cell V[beta] Families | p. 120 |
Conclusion | p. 121 |
The Diversity and Characteristics of T-Cell Receptors Specific for Single Non-H2 Histocompatibility Antigens | p. 125 |
Dichotomy Between Requirements for Allograft Rejection and CTL Generation | p. 126 |
H4-Specific TCRs Expressed by CTLs | p. 127 |
H4-Specific TCRs Expressed by Graft-Infiltrating CD8+ T Cells | p. 131 |
HY-Specific TCR [beta] Chains | p. 134 |
Conclusion | p. 136 |
Infectious Tolerance with CD4 Monoclonal Antibodies: A Role for Minors in Linked Suppression | p. 141 |
Introduction | p. 141 |
Evidence for Dominant Tolerance Mediated by CD4 T Cells | p. 142 |
How is Dominant Tolerance Maintained Life-Long? | p. 142 |
How is Dominant Tolerance Achieved? | p. 142 |
Therapeutic Application | p. 143 |
Skin-Specific Minor Histocompatibility Antigens: A Critical Appraisal | p. 149 |
Discovery of Putative Skin-Specific Histocompatibility Antigens | p. 149 |
The Number and Mapping of Skn Loci | p. 150 |
Problems with Skn Antigens | p. 151 |
Detection and Analysis of Epidermal H Antigens | p. 153 |
Evidence for Additional Epa Antigens | p. 155 |
Antigens Encountered During Organ Transplantation | p. 159 |
Evidence for Tissue-Specific Alloantigens | p. 159 |
Identification of T Cells Recognizing Tissue-Specific MHC Alloantigens | p. 161 |
Conventional and Tissue-Specific Minor H Antigens | p. 165 |
Tissue-Specific Autoantigens and Utoimmunity | p. 165 |
Conclusion | p. 166 |
Human Tumor Antigens Recognizes by Cytolytic T Lymphocytes: Towards Vaccination | p. 171 |
Isolation of T Cells Recognizing Human Tumor Antigens | p. 171 |
Strategies for the Identification of Human Tumor Antigens | p. 171 |
Nature of Human Tumor Antigens Recognized by CTLS | p. 174 |
Antigens Resulting from Mutations | p. 177 |
Towards Vaccination | p. 178 |
Index | p. 183 |
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