| A Phylogenetic View of Bacterial Ribonucleases | p. 1 |
| Functions for Life | p. 2 |
| Ribonucleases of the Paleome | p. 4 |
| Ribonucleases of the Cenome | p. 26 |
| Provisional Conclusion | p. 30 |
| References | p. 32 |
| RNA Processing and Decay in Bacteriophage T4 | p. 43 |
| Introduction | p. 44 |
| Part 1: Mechanisms and Regulation of mRNA Degradation During T4 Development | p. 45 |
| Part 2: Transfer RNA Processing | p. 66 |
| References | p. 78 |
| Endonucleolytic Initiation of mRNA Decay in Escherichia coli | p. 91 |
| Background | p. 92 |
| General Features of mRNA Degradation in E. coli | p. 97 |
| Evidence for Diverse Pathways of mRNA Degradation in E. Coli | p. 102 |
| The Structure of RNase E | p. 106 |
| Substrate Specificity and Catalytic Mechanism of RNase E | p. 112 |
| Modulators and Adaptors of RNase E | p. 118 |
| Other Endoribonucleases in E. coli | p. 119 |
| Phylogenetic Distribution of RNase E and The RNA Degradosome | p. 123 |
| References | p. 125 |
| Poly(A)-Assisted RNA Decay and Modulators of RNA Stability | p. 137 |
| Introduction | p. 138 |
| Regulation of Gene Expression in Response to Environmental Signals | p. 139 |
| Polyadenylation and Poly(A)-Dependent Decay | p. 142 |
| Other Modulators of RNA Stability | p. 158 |
| Conclusions and Open Questions | p. 167 |
| References | p. 169 |
| The Role of 3'-5' Exoribonucleases in RNA Degradation | p. 187 |
| Introduction | p. 188 |
| Polynucleotide Phosphorylase (PNPase) | p. 193 |
| RNase II | p. 200 |
| RNase R | p. 205 |
| Oligoribonuclease | p. 210 |
| Mechanisms of RNA Degradation | p. 212 |
| Concluding Remarks | p. 217 |
| References | p. 218 |
| Messenger RNA Decay and Maturation in Bacillus Subtilis | p. 231 |
| Introduction and Historical Perspective | p. 232 |
| The 5' End | p. 234 |
| Body of The Message | p. 251 |
| The 3' End | p. 258 |
| Regulated mRNA Decay | p. 264 |
| Conclusion | p. 267 |
| References | p. 267 |
| RNA Degradation in Archaea and Gram-Negative Bacteria Different from Escherichia coli | p. 275 |
| Introduction | p. 276 |
| RNA Degradation Mechanisms in Bacteria and Eukarya | p. 277 |
| Features of mRNA in Archaea | p. 287 |
| Archaeal Proteins with Unexpected Endoribonucleolytic Activities | p. 293 |
| Archaeal Proteins with Similarities to Bacterial or Eukaryotic Proteins Involved in RNA Degradation-A Short Overview | p. 299 |
| The Archaeal Exosome | p. 300 |
| RNA Degradation in Archaea | p. 308 |
| Concluding Remarks | p. 310 |
| References | p. 311 |
| The Making of tRNAs and More - RNas P and tRNase Z | p. 319 |
| Introduction | p. 320 |
| Processing by RNase P | p. 324 |
| Removal of the tRNA 3'-Trailer | p. 347 |
| References | p. 358 |
| Maturation and Degradation of Ribosomal RNA in Bacteria | p. 369 |
| Introduction | p. 369 |
| Early Studies of rRNA Maturation and Degradation | p. 370 |
| Current Understanding of rRNA Processing | p. 373 |
| Degradation of rRNA | p. 383 |
| References | p. 388 |
| RNA Polyadenylation and Decay in Mitochondria and Chloroplasts | p. 393 |
| Introduction | p. 394 |
| Polyadenylation of RNA | p. 395 |
| The Enzymes | p. 399 |
| RNA Degradation and Polyadenylation in Chloroplasts | p. 408 |
| RNA Degradation and Polyadenylation in Mitochondria | p. 409 |
| Conclusions and Perspectives | p. 413 |
| References | p. 414 |
| Killer and Protective Ribosomes | p. 423 |
| Introduction | p. 424 |
| Nucleolytic Versus Non-nucleolytic Inactivation of mRNAs | p. 426 |
| Translation-Degradation Interplay: Conceptual Ambiguities and Technical Caveats | p. 430 |
| Killer Ribosomes | p. 436 |
| Protective Ribosomes | p. 446 |
| Concluding Remarks | p. 457 |
| References | p. 458 |
| mRNA Interferases, Sequence-Specific Endoribonucleases from the Toxin-Antitoxin Systems | p. 467 |
| Introduction | p. 468 |
| MazF: An mRNA Interferase | p. 471 |
| MazF Homologues and Other mRNA Interferases | p. 480 |
| Other Toxins in Ta Systems | p. 489 |
| The Regulation of MazF Expression Under Stress Conditions | p. 491 |
| Concluding Remarks | p. 494 |
| References | p. 496 |
| Index | p. 501 |
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