Molecular Mechanisms of Metabolic Arrest

Life in Limbo

By: K.B. Storey (Editor)

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Hardcover | 15 June 2001 | Edition Number 1

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216 Pages

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Many organisms can reduce their resting metabolic rate to a state of suspended animation to allow them to survive in adverse environmental conditions. Molecular Mechanisms of Metabolic Arrest focuses on the latest opinions of molecular mechanisms and principles of dormancy regulation, highlighting various new concepts in metabolic rate control. This book will strongly appeal to all molecular and comparative scientists studying organismal responses to environmental stress. It is also of relevance to medical researchers interested in how natural systems of hypometabolism can be applied to relevant problems in medicine.

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Turning Down the Fires Fof Life: Metabolic Regulation of Hibernation and Estivation
Introduction
Reversible phosphorylation and enzyme control
Signal transduction
Protein adaptation
Genes and hypometabolism
Conclusions
References
Hibernation, A State Of Natural Tolerance To Profound Reduction In Organ Blood Flow and Oxygen Delivery Capacity
Introduction - general features
Modulation of enzyme activity in hibernation
Hibernation induction factors
Hibernation specific factors
Adaptive changes in hibernation
Suppression of protein synthesis in brain during hibernation
Changes in gene expression during hibernation
Summary
References
The Atp-Sensitive Potassium Channel: A Metaboic Sensor
Introduction
The plasmalemmal K ATP channels
Conclusions
References
Mitochondrial Proton Leak in Metaboic Depression
Introduction
Mitochondrial proton leak
The contribution of mitochondrial proton cycling to standard metabolic rate
The problem of mitochondrial proton cycling in metabolic depression
Proton cycling in mitochondrial isolated from metabolically depressed animals
Proton cycling in intact cells isolated metabolically depressed animals
Conclusions
References
The Hypoxic Brain: Supressing Energy-Expensive Membrane Functions By Regulation Of Receptors and Ion Channels
Introduction
Significance
Nature of hypoxic brain injury in oxygen-sensitive brains: a brief overview
Hypoxia-tolerant vertebrate neurons
Metabolic and ion channel arrest in hypoxia-tolerant neurons: what are the targets
Electrical activity and properties of neurons from anoxia-tolerant neurons
Conclusions
References
Anoxia Survival and Metabolic Arrest In The Turtle
Introduction
Metabolism during anoxic submergence
Aquatic respiration in turtles
References
Thermostasis in Hypoxic Animals
Introduction
Occurrence of hypoxia-induced hypothermia
Mechanism of hypoxia-induced hypothermia
Potential mediators of hypothermia
Functional significance of hypoxia-induced hypothermia
References
Cellular Interactions Between Respiration and Thermoregulation: The Paramecium
Introduction
Thermoregulation in the paramecium
Hypoxia-induced decreases in Ts in the paramecium
Conclusion
References
Coupling Of Stress-Induced Gene Expression With Growth Arrest In Budding Yeast
Introduction - the general biological context
The general stress response in budding yeast
References
Time For A Rest: Programmed Dispause In Insects
Introduction
The critical role of the brain
Diapause up-regulated genes
Diapause down-regulated genes
Gene expression associated with hormonal regulators of diapause
The gaps
References
Do Stress Proteins Embryos During Metabolic Arrest and Dispause?
General properties and regulation of diapause
Protein folding, molecular chaperones and the small heat/shock/a-crystallin proteins
Molecular chaperones and insect diapause
Artemia diapause and p26, a small heat shock/a-crystallin protein
Perspectives and conclusion
References
Molecular Mechanisms Of Desiccation Tolerance In Plants
Introduction
Resurrection plants
Proteins with protective properties (LEA proteins)
Activation of gene expression during dehydration: preparation for survival
Regulation of gene expression in C. plantagineum during dehydration
Perception of dehydration
Conclusions
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

Molecular Mechanisms of Metabolic Arrest

Life in Limbo

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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