Nanocomposite Particles for Bio-Applications

Name: Nanocomposite Particles for Bio-Applications
Brand: Pan Stanford Publishing Pte Ltd
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Materials and Bio-Interfaces

By: Tito Trindade (Editor), Ana Luisa Daniel da Silva (Editor)

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Hardcover | 8 August 2011 | Edition Number 1

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Hardcover
316 Pages

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22.9 x 15.2 x 2.03

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Providing a concise examination of the synthesis and properties of nanocomposite particles in regards to diverse bio-applications, this informative guide explores the chemical design of nanocomposite particles—their properties as well as those of their constituent materials—and the tailoring of bio-interfaces that may be relevant for the fields of clinical diagnosis and drug-delivery procedures. Including examples of how particles composed of a polymer matrix can contain dispersed inorganic nanophases and other bio-functionalized nanomaterials as well as commentary on their practical use, this in-depth analysis is an integral reference for the study of nanotechnology.

Industry Reviews

"The book provides an excellent and timely overview on the chemistry and biological applications of various types of nanoparticles and their composites. Starting from the fundamental science of preparation and surface functionalization, the book, following a clear and didactic approach, covers the most important topics which are related to applications of nanoparticles in the biological and medical field. The chapters provide basic principles, detailed insights, and possible applications of the discussed systems and refer the more interested reader to the most important literature. This makes the book a comprehensive reference for graduate students and senior scientists who want to enter this fascinating scientific field at the crossroads of various disciplines."
-Prof. Guido Kickelbick, Saarland University, Germany

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Non-Fiction Engineering & Technology Technology in General Nanotechnology Medicine Pre-Clinical Medicine & Basic Sciences Nursing & Ancillary Services Biomedical Engineering

List of Figures	p. xi
List of Tables	p. xix
Preface	p. xxi
From Nanoparticles to Nanocomposites: A Brief Overview	p. 1
Nanoscience and Nanotechnology: An introduction	p. 1
Nanoparticles' Diversity	p. 3
Quantum dots	p. 4
Iron oxides	p. 4
Metal nanoparticles	p. 5
Surface Modification of Nanoparticles	p. 7
Ligand exchange reactions	p. 8
Inorganic nanocoating	p. 8
Encapsulation in polymers	p. 10
Designing Biointerfaces over Nanoparticles	p. 11
Challenges for the Future... Nanosafety for Today	p. 14
Polymers for Biomedical Applications: Chemical Modification and Biofunctionalization	p. 21
Drug Delivery Systems	p. 21
Hydrogels	p. 23
Application of hydrogels	p. 24
Types of hydrogels	p. 25
Bioadhesives	p. 30
Surface Modification	p. 34
Surface modification by ultra-violet radiation	p. 36
Plasma treatment	p. 37
Plasma generation	p. 37
Plasma polymerization and surface modification of polymers	p. 38
Concluding Remarks	p. 39
Nanocapsules as Carriers for the Transport and Targeted Delivery of Bioactive Molecules	p. 45
Introduction	p. 45
Polymeric Nanocapsules: Production and Characterization	p. 45
Nanocapsules made of synthetic polymers	p. 47
Polyacrylate nanocapsules	p. 47
Polyester nanocapsules	p. 49
Nanocapsules made of natural polymers	p. 50
Lipid nanocapsules	p. 51
Therapeutical Applications of Nanocapsules	p. 52
Nanocapsules for oral drug delivery	p. 52
Nanocapsules for oral peptide delivery	p. 52
Nanocapsules for oral delivery of lipophilic low molecular weight drugs	p. 54
Nanocapsules as nasal drug carriers	p. 55
Nanocapsules as ocular drug carriers	p. 56
Nanocapsules in cancer therapy	p. 58
Nanocapsules as carriers for gene therapy	p. 59
Conclusions	p. 60
Inorganic Nanoparticles Biofunctionalization	p. 69
Bioeonjugation of Nanoparticles	p. 69
Nanoparticles and Their Surface Properties	p. 70
Surface capping of nanoparticles	p. 70
Semiconductor quantum dots and metallic nanoparticles	p. 71
Silica nanoparticles and silica encapsulation	p. 72
Attachment Schemes	p. 74
Covalent attachment	p. 74
Non-covalent attachment	p. 75
Affinity binding	p. 76
Specific Cases	p. 76
Proteins	p. 76
DNA	p. 78
Avidin	p. 79
Phospholipid encapsulation and functionalization	p. 81
Applications	p. 83
Cellular imaging	p. 83
Drug delivery	p. 84
Bioluminescence resonance energy transfer	p. 86
Hyperthermia	p. 87
Conclusion	p. 88
Silica-Based Materials: Bioprocesses and Nanocomposites	p. 97
Natural Silica Nanocomposites	p. 97
Introduction	p. 97
Diatom biosilica	p. 98
Sponge biosilica	p. 99
(Bio)-technological applications of biosilica	p. 100
Biomimetic Silica Nanocomposites	p. 102
Introduction	p. 102
Silica nanocomposites based on natural templates	p. 102
Silica nanocomposites based on model templates	p. 103
Synthetic peptides	p. 103
Synthetic polyamines	p. 103
Biological templates	p. 105
Biomimetism: How far can we go?	p. 106
Bio-Inspired Silica Nanocomposites	p. 107
Introduction	p. 107
Biotechnological and medical applications	p. 107
Perspectives	p. 109
Synthetic Strategies for Polymer-Based Nanocomposite Particles	p. 115
Introduction	p. 115
Surfaces and Interfaces: Chemical Modification of Nanoparticles	p. 117
In situ Synthetic Strategies for Polymer-Based Colloidal Nanocomposites	p. 120
In situ preparation of the fillers	p. 121
Sol-gel methods	p. 121
In situ polymerization of the matrix	p. 123
Organic solvent-based methods: Dispersion polymerization	p. 124
Water-based methods: Emulsion and miniemulsion polymerization	p. 125
Controlled polymerization: Surface initiated polymerization(SIP)	p. 128
Atom Transfer Radical Polymerization Atrp	p. 128
Reversible Addition Fragmentation chain transfer (Raft) polymerization	p. 130
Combined controlled polymerization mechanisms	p. 132
Functionalization of Polymer-Based Nanocomposites for Bio-Applications	p. 132
Final Remarks	p. 134
Synthesis of Nanocomposite Particles Using Supercritical Fluids: A Bridge with Bio-applications	p. 145
Introduction	p. 145
Supercritical Fluids: Definition and Current use in, Bio-Applications	p. 146
Definition	p. 146
Scps in biomedical applications	p. 148
Development of drug delivery systems	p. 148
scC02 for purification and sterilization	p. 150
Can Scfs be Used to Introduce Inorganic NPs into Polymers?	p. 150
Formation of hybrid organic-inorganic NPs in Scps(route 1)	p. 152
Encapsulation of inorganic NPs into a polymer shell (route 2)	p. 153
Polymer swelling and in situ growth of inorganic NPs (route 3)	p. 154
Polymer swelling by scC02	p. 155
Chemical transformation of impregnated metal precursor	p. 155
Conclusions	p. 157
Biocomposites Containing Magnetic Nanoparticles	p. 165
Introduction	p. 165
Magnetic Properties	p. 167
Magnetism at nanoscale level: Concepts and main phenomena	p. 167
Basic concepts	p. 167
Systems with interactions between magnetic centers	p. 168
Superparamagnetism	p. 169
Magnetism concepts subjacent to bio-applicatons	p. 172
Magnetic separation and drug delivery	p. 172
Magnetic resonance imaging (Mri)	p. 172
Magnetic hyperthermia	p. 173
Magnetic Nanoparticles for Bio-Applications	p. 175
Iron oxide nanoparticles	p. 175
Metallic nanoparticles	p. 176
Metal alloy nanoparticles	p. 177
Bimagnetic nanoparticles	p. 177
Strategies of Synthesis of Magnetic Biocomposite Nanoparticles	p. 178
In situ formation of magnetic nanoparticles	p. 179
Iron oxide nanoparticles	p. 180
Other magnetic nanoparticles	p. 183
Encapsulation of magnetic nanoparticles within biopolymers	p. 185
Conclusions and Future Outlook	p. 186
Multifunctional Nanoeomposite Particles for Biomedical Applications	p. 193
Introduction	p. 193
Types of Multifunctional Magnetic-Fluorescent Nanocomposites	p. 194
Main Approaches to the Preparation of Multifunctional Magnetic-Fluorescent Nanocomposites	p. 195
Silica coated magnetic-fluorescent nanoparticles	p. 196
Organic polymer coated magnetic cores treated with fluorescent entities	p. 198
Ionic assemblies of magnetic cores and fluorescent entities	p. 199
Fluoreseently-labeled lipid coated magnetic nanoparticles	p. 200
Magnetic core directly linked to fluorescent entity via a molecular spacer	p. 201
Magnetic cores coated by fluorescent semiconducting shells	p. 201
Magnetically-doped Qds	p. 202
Magnetic nanoparticles and Qds embedded within a polymer or silica matrix	p. 203
Biomedical Applications	p. 204
Bio-imaging probes	p. 204
Cell tracking, sorting and bioseparation	p. 206
Applications in nanomedicine	p. 208
Conclusions and Future Outlook	p. 210
Bio-Applications of Functionalized Magnetic Nanoparticles and Their Nanocomposites	p. 217
Introduction	p. 217
Fundaments of Nanomagnetism	p. 220
Single-domain particles	p. 220
Magnetic anisotropy energy	p. 220
Superparamagnetism	p. 221
Fundaments of Colloidal Stability	p. 223
Bio-Applications of Magnetic Nanoparticles	p. 224
Magnetic separation	p. 224
Drug delivery	p. 225
Nuclear magnetic resonance imaging (Mri)	p. 227
Contrast agents based on superparamagnetic nanomagnets	p. 228
Magnetobiosensors	p. 231
Magnetobiosensors based on magnetorelaxometry	p. 232
Magnetobiosensors based on magnetoresistance	p. 233
Magnetosensors based on Hall effect	p. 234
Magnetoplasmonics	p. 234
Magnetic hyperthermia	p. 235
Summary and Outlook	p. 238
Anti-Microbial Polymer Nanocomposites	p. 249
Introduction	p. 249
Packaging	p. 250
Textiles	p. 250
Coatings	p. 252
Antimicrobial coatings	p. 252
Medicine, pathology and surgical implants/ biomedical coatings	p. 253
Anti-Microbial Polymer-Based Nanocomposites	p. 253
Mechanisms of Antibacterial Action	p. 256
Detection of microbes	p. 256
Control of microbial growth	p. 257
Environmental and Health Concerns	p. 260
Biosensing Applications Using Nanoparticles	p. 265
Biosensors: A Definition	p. 265
Uses of Gold Nanoparticles	p. 266
Tailoring biointerfaces over gold nanoparticles	p. 267
Biosensing applications of gold nanoparticles	p. 268
Crosslinking-based biosensing	p. 269
Non-crosslmking-based biosensing	p. 272
Semiconductor Quantum Dots	p. 273
Properties of quantum dots	p. 273
Biosensing with quantum dots	p. 273
Immunosensing	p. 274
Dna assays	p. 274
Resonance energy transfer-based assays	p. 275
Outlook Remarks	p. 277
Index	p. 283
Table of Contents provided by Ingram. All Rights Reserved.

Nanocomposite Particles for Bio-Applications

Materials and Bio-Interfaces

At a Glance

Hardcover

Industry Reviews

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How to return your order

Defective items

You Can Find This Book In

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