Neuronal Networks of the Hippocampus

By: Richard Miles, Roger D. Traub

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Paperback | 29 May 2008

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304 Pages

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22.8 x 15.2 x 2.0

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The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Using a combined experimental-theoretical approach unique in neuroscience, the authors present important techniques for the physiological reconstruction of a large biological neuronal network. They begin by discussing experimental studies of the CA3 hippocampal region in vitro, focusing on single-cell and synaptic electrophysiology, particularly the effects a single neuron exerts on its neighbours. This is followed by a description of a computer model of the system, first for individual cells then for the entire detailed network, and the model is compared with experiments under a variety of conditions. The results shed significant light into the mechanisms of epilepsy, electroencephalograms, and biological oscillations and provide an excellent test case for theories of neural networks. Researchers in neurophysiology and physiological psychology, physicians concerned with epilepsy and related disorders, and researchers in computational neuroscience will find this book an invaluable resource.

Industry Reviews

"...integrates experiments and computer modeling into seamless fabric, something still rare in the neurosciences. The use of arguments from statistical physics and dynamical systems theory is compelling and to the point. The monograph should be required reading for any researcher seriously interested in networks of complicated and highly interconnected neurons..." Christof Koch, Science "Traub and Miles are to be congratulated not only for the intellectual and empirical achievements embodied in this book, but also for the delicate balance struck between detail and clarity." Bruce L. McNaughton, Trends in Neuroscience

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You Can Find This Book In

Non-Fiction Science Biology, Life Sciences Life Sciences in General Neurosciences Nature & The Natural World Medicine Pre-Clinical Medicine & Basic Sciences Physiology Clinical & Internal Medicine Neurology & Clinical Neurophysiology

Acknowledgments
Prologue
The hippocampus in context
Physiology of single neurons: voltage- and ligand-gated ionic channels
Synaptic function and organization of the CA3 region
The single-cell model
Model of the CA3 network
Collective behaviours of the CA3 network: experiment and model
Collective behaviours of the CA3 network: spontaneous oscillations and synchronized synaptic potentials
Field effects
Theoretical approaches: mathematical neural networks
Appendix
Conclusion
Notes
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

Neuronal Networks of the Hippocampus

At a Glance

Paperback

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

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