NeuroPET

Positron Emission Tomography in Neuroscience and Clinical Neurology

By: K. Herholz, W.-D. Heiss, P. Herscovitch

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Multi-Item Pack | 16 June 2004

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316 Pages

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Positron emission tomography (PET) provides unbiased in vivo measurement of local tracer activity at very high sensitivity. This is a unique property unmatched by other imaging modalities. When PETwas introduced into medicine more than 25years ago, the first organ of major interest was the brain. Since then, PET has flourished as an extremely powerful and versatile tool in scientific brain studies, whereas its use as a diagnostic tool in clinical neurology remains limited. This is in contrast to its use in otherapplications, particularlyoncology, where its value in clinical diagnosis is more widely appreciated. Wethink this situation is unfortu- nate, because PET can contribute more to clinical neurology and clinical neuro- science than is generally perceived today. Realization of its potential will require very close cooperation between PETexperts and clinicians and the integration of PET into clinical studies. Thus, in this book we review PETin neuroscience, with particular emphasis on findings that indicate its potential for improving diagno- sis and treatment in neurology and psychiatry. We want to improve the trans- ferability of the enormous scientific advances in brain PET into clinical care so as to produce tangible human benefit [1]. Wewish to guide both nuclear medicine specialists and also neurologists and psychiatrists in the use of PET. We there- fore focus on practical and potentially clinically relevant issues, identifying solid ground as well as open questions that require further research, and we see this targeted presentation as complementary to more general PET textbooks and reviews.

Industry Reviews

From the reviews:

This is the most comprehensive book written to date which reviews applications of PET in brain disorders, measurements of regional brain function, molecular imaging and PET methodology.

Rarer states are reviewed as well as those not normally considered as presenting with functional brain lesions such as pain and migraine.

For those with clinical PET facilities, this book will indentify how this technology could be exploited for the care of brain disorder patients.

RAD Magazine, December, 2005

"This book is by world authorities in both the methodology of positron emission tomography (PET) and its applications in clinical neurology. According to the authors, it is intended to 'guide both nuclear medicine specialists and also neurologists and psychiatrists in the use of PET'; I assume they also meant to include neurosurgeons, neurophysiologists and clinical neuroscientists. ... This book is unique in its kind. ... it will prove an invaluable source of historical information about one of the major revolutions in understanding brain diseases." (J. -C. Baron, Acta Neurochirurgica, Vol. 147, 2005)

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Non-Fiction Medicine Clinical & Internal Medicine Neurology & Clinical Neurophysiology Other Branches of Medicine Medical Imaging Tomography Nuclear Medicine Surgery Neurosurgery

Introduction	p. 1
Clinical Studies	p. 7
Dementia and Memory Disorders	p. 7
Clinical and Research Issues	p. 7
Alzheimer's Disease and Mild Cognitive Impairment	p. 9
Cerebral Glucose Metabolism	p. 9
Cholinergic Degeneration	p. 20
Other Receptors and Transmitters	p. 22
Amyloid Imaging	p. 22
Activation Studies	p. 23
Dementia with Lewy Bodies	p. 24
Frontotemporal Dementia and Related Disorders	p. 25
Vascular Dementia	p. 28
Creutzfeldt-Jakob Disease	p. 30
Other Memory Disorders	p. 31
Hypoxic and Global Ischemic Brain Damage	p. 31
Other Amnesic Syndromes	p. 31
Movement Disorders	p. 32
Idiopathic Parkinson Disease	p. 35
Diagnostic Issues	p. 35
Dopamine Synthesis	p. 37
Dopamine Release and Turnover	p. 39
Dopamine Transporters	p. 39
Vesicular Monoamine Transporter	p. 40
Dopamine Receptors	p. 40
Mesocortical Dopaminergic Innervation	p. 41
Other Transmitters	p. 41
Resting Glucose Metabolism	p. 41
Activation Studies	p. 42
Familial PD	p. 42
Disease Progression	p. 44
Depression in PD	p. 45
Improving and Understanding Treatment Effects	p. 45
Multiple System Atrophy	p. 48
Olivo-ponto-cerebellar Atrophy	p. 49
Striatonigral Degeneration	p. 50
Shy-Drager Syndrome	p. 50
Other Neurodegenerative Disorders	p. 52
Progressive Supranuclear Palsy	p. 52
Corticobasal Degeneration	p. 53
Disorders with Abnormal Deposition of Metals	p. 55
Parkinsonism Attributable to Toxic and Inflammatory Brain Damage	p. 55
Amyotrophic Lateral Sclerosis	p. 56
Other Rare Disorders	p. 56
Hyperkinetic Syndromes	p. 56
Huntington's Chorea (Huntington Disease)	p. 56
Other Choreic Disorders	p. 58
Restless Legs Syndrome	p. 58
Essential and Orthostatic Tremor	p. 59
Tourette Syndrome	p. 59
Dystonia and Related Disorders	p. 60
Idiopathic Dystonia and Torticollis	p. 60
DOPA-responsive Dystonia	p. 61
Dystonia Attributable to Localized Lesions or Degeneration	p. 61
Ataxia	p. 61
Spinocerebellar Ataxia	p. 62
Friedreich's Ataxia	p. 63
Other Ataxias	p. 63
Brain Tumors	p. 63
Biological Grading	p. 64
Glucose Consumption	p. 64
Amino Acid Uptake	p. 68
Nucleoside Uptake	p. 71
PET-Guided Stereotactic Biopsy	p. 71
Differentiation Between Recurrent Tumor and Radiation Necrosis	p. 71
Monitoring of Therapy	p. 73
Identification of Hypoxic Tumor Tissue	p. 77
Improving and Planning Therapy	p. 77
New Therapies	p. 79
Other Tracers for Brain Tumors	p. 80
Extracranial Tumors of the Nervous System	p. 80
Detection of Primary Tumors	p. 81
Activation Studies	p. 81
Motor Function	p. 82
Language	p. 84
Cerebrovascular Disease	p. 86
Ischemic Stroke	p. 87
Intracerebral and Subdural Hemorrhage	p. 89
Subarachnoid Hemorrhage	p. 90
Remote Effects (Diaschisis)	p. 90
Chronic Hemodynamic Impairment	p. 93
Moyamoya Disease	p. 95
Genetic Disorders (MELAS, CADASIL)	p. 95
Brain Function and Recovery After Stroke	p. 95
Aphasia	p. 96
Motor Function	p. 98
Neglect	p. 99
Epilepsy	p. 100
Localization of Epileptogenic Foci	p. 101
Temporal Lobe Epilepsy	p. 101
Neocortical Focal Epilepsy	p. 105
Ictal Studies	p. 105
GABA-A and Benzodiazepine Receptors	p. 106
Other Transmitters and Receptors	p. 107
Inflammatory Lesions and Glial Reaction	p. 108
Progression of Epileptic Lesions	p. 109
Prediction of Surgical Outcome	p. 109
Malformations of Cortical Development	p. 109
Childhood Epileptic Syndromes	p. 111
Language Dominance	p. 112
Effects of Surgical Intervention and Medical Treatment	p. 112
Generalized Epilepsy	p. 113
Other Neurological Disorders	p. 113
Traumatic Brain Injury	p. 113
Persistent Vegetative State	p. 114
Perinatal Brain Damage	p. 115
Inflammatory Disease	p. 117
Pain	p. 119
Migraine and Cluster Headache	p. 121
Narcolepsy	p. 122
Hypoparathyroidism (Fahr's Disease)	p. 122
Systemic Inherited Metabolic Disorders	p. 122
Psychiatric Disorders	p. 123
Depression	p. 124
Cerebral Blood Flow and Cerebral Metabolic Rate (Glucose)	p. 125
Serotonin Receptors	p. 127
Serotonin Transporters	p. 128
Other Transmitter Systems	p. 128
Fatigue	p. 128
Schizophrenia	p. 129
CBF and Energy Metabolism	p. 129
Activation Studies	p. 129
Dopamine Receptors and Dopamine Release	p. 130
Other Receptors	p. 131
Receptor Binding of Antipsychotic Drugs	p. 131
Anxiety Disorders	p. 131
Panic Disorder	p. 132
Phobic Disorders	p. 132
Obsessive-compulsive Disorder	p. 133
Posttraumatic Stress Disorder	p. 134
Drug and Substance Abuse	p. 135
Alcoholism	p. 135
Cocaine	p. 136
Amphetamine and Derivatives	p. 138
Opiates	p. 139
Nicotine	p. 140
Hallucinogens	p. 140
Phencyclidine	p. 140
Personality and Behavioral Disorders	p. 141
Borderline Personality Disorder	p. 141
Violence and Suicide	p. 141
Anorexia Nervosa and Bulimia	p. 142
Imaging Brain Function	p. 143
Blood-Brain Barrier Transfer	p. 143
Cerebral Blood Flow	p. 147
Oxygen Consumption	p. 149
Glucose Consumption	p. 150
Influence of Brain Function on CBF and Metabolism	p. 152
Wakefulness and Sleep	p. 153
Effect of Drugs	p. 153
The “Resting State”	p. 154
Activation Studies	p. 155
Tissue Oxygen Pressure and pH	p. 156
Amino Acid Transport and Protein Synthesis	p. 156
Transport-only Tracers	p. 157
Tracers with Incorporation into Proteins	p. 158
Precursors and Analogues for Transmitter Systems	p. 160
Nucleosides and DNA Synthesis	p. 160
Molecular Imaging	p. 161
Herpes Simplex Virus Thymidine Kinase Imaging	p. 163
Reporter Gene Imaging	p. 164
Oligonucleotides	p. 164
Apoptosis and p53	p. 164
Cell Trafficking	p. 164
Angiogenesis	p. 165
Dopamine System	p. 165
Precursors and Analogues of Dopamine	p. 165
Dopamine Transporter	p. 167
Vesicular Monoamine Transporter	p. 168
D1 Receptors	p. 169
D2 Receptors	p. 169
Studies of Synaptic Dopamine Release	p. 170
Monoamine Oxidase	p. 172
Cholinergic System	p. 173
Acetylcholine Synthesis	p. 173
Vesicular Acetylcholine Transporter	p. 173
Nicotinic Receptors	p. 173
Muscarinic Receptors	p. 174
Acetylcholine Esterase	p. 174
Serotonin System	p. 176
Serotonin Precursors	p. 176
Serotonin Transporter	p. 177
Serotonin Receptors	p. 177
Serotonin 1A Receptors	p. 177
Serotonin 2A Receptors	p. 180
Gamma-aminobutyric acid (GABA)	p. 180
Central Benzodiazepine-binding Sites	p. 181
Peripheral Benzodiazepine Receptors	p. 181
Glutamate and NMDA Receptors	p. 182
Adenosine Receptors	p. 182
Histamine Receptors	p. 182
Cannabinoid Receptors	p. 183
Opioid Receptors and Sigma Receptor	p. 183
Steroid Receptors	p. 184
Substance P	p. 184
Secondary Neurotransmitters	p. 185
Data Acquisition, Reconstruction, Modeling, Statistics	p. 187
Positron Emitters and Tracers	p. 187
Scanners and Detector Systems	p. 189
Data Acquisition	p. 191
Image Reconstruction	p. 192
Motion Detection and Correction	p. 194
Data Visualization	p. 194
Image Coregistration	p. 195
Fiducial Markers	p. 196
Matching of Brain Structures	p. 197
Algorithms for Maximization of Similarity	p. 198
PET/CT and PET/MRI Scanners	p. 199
Anatomical Standardization	p. 200
Orientation of Transaxial Slices	p. 200
Matching of Individual Brains to Image Templates (“Spatial Normalization”)	p. 201
Atlases for Identification of Anatomical Structures	p. 202
Physiological Modeling	p. 203
Blood and Homogeneous Tissue (One Tissue Compartment)	p. 205
Transport across the BBB	p. 206
Cerebral Blood Flow	p. 207
Mixed Effects of Transport and Blood Flow	p. 211
Measurement of the Partition Coefficient	p. 211
Saturable Transport and Enzyme Reactions	p. 212
Metabolism	p. 212
Irreversible Metabolism (Metabolic Trapping)	p. 213
Measurement of Local Cerebral Glucose Metabolism	p. 214
The Reference Tissue Model for Dopamine Synthesis and Storage	p. 216
Reversible Metabolism or Binding	p. 217
Receptor Binding	p. 218
Irreversible Receptor Binding	p. 219
Equilibrium Approaches for Quantification of Reversible Receptor Binding	p. 220
Extraction of Model Parameters from Kinetic Data	p. 222
Quantitative Data Analysis	p. 223
Regions/Volumes of Interest	p. 225
Partial Volume Correction	p. 226
Statistical Models for Quantitative Data	p. 227
Parametric Imaging	p. 231
Statistical Parametric Mapping	p. 232
Lesion Detection and Pattern Recognition	p. 233
References	p. 235
Subject Index	p. 285
Table of Contents provided by Publisher. All Rights Reserved.

NeuroPET

Positron Emission Tomography in Neuroscience and Clinical Neurology

At a Glance

Multi-Item Pack

Industry Reviews

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How to return your order

Defective items

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