Preface: William Slikker, Jr., Russell J. Andrews, and Bruce
Trembly.
.
Part I: The Human Experience of Neuroprotection:.
1. Neuroprotection Trek?The Next Generation: The
Measurement Is the Message: Russell J. Andrews.
2. Protective Effect of Neuromonitoring during Cardiac Surgery:
Harvey L. Edmonds, Jr.
3. Neuropsychiatric Alterations in MDMA Users: Preliminary
Findings: Ronald I. Herning, Warren Better, Kimberly Tate, And Jean
L. Cadet.
4. Intraoperative Monitoring during Aneurysm Surgery as a
Neuroprotective Activity with Reference to Evoked Potential and
Microvascular Doppler Techniques: Karl E. Sanzenbacher.
5. Panel of Biomarkers Predicts Stroke: D T Laskowitz, R
Blessing, J Floyd, W D White, And J R Lynch.
6. Evaluating Neuroprotective Agents in Coronary Artery Bypass
Surgery: Stanton Newman.
7. Questions and Answers: Session I: The Human Experience of
Neuroprotection.
.
Part II: Mechanisms of Neuroprotection (1):.
8. Delineating and Understanding Cerebellar Neuroprotective
Pathways: Potential Implication for Protecting the Cortex: Xuan Wu,
Xueying Jiang, Ann M. Marini, And Robert H. Lipsky.
9. A Role for Calpain in Optic Neuritis: M Kelly Guyton, Eric A.
Sribnick, Swapan K. Ray, And Naren L. Banik.
10. Activation of Neuroprotective Pathways by Metabotropic Group
I Glutamate Receptors: A Potential Target for Drug Discovery?:
Andrius Baskys, Liwei Fang, And Ildar Bayazitov.
11. Antiapoptotic and Anti-inflammatory Mechanisms of Heat-Shock
Protein Protection: Midori A. Yenari, Jialing Liu, Zhen Zheng,
Zinaida S. Vexler, Jong Eun Lee, And Rona G. Giffard.
12. Neuroprotection by NGF in the PC12 In Vitro OGD Model:
Involvement of Mitogen-Activated Protein Kinases and Gene
Expression: Rinat Tabakman, Hao Jiang, Iris Shahar, Hadar
Arien-Zakay, Robert A. Levine, And Philip Lazarovici.
13. Role of Peroxynitrite in Methamphetamine-Induced
Dopaminergic Neurodegeneration and Neuroprotection by Antioxidants
and Selective NOS Inhibitors: Syed F. Ali, Syed Z. Imam, And Yossef
Itzhak.
14. Questions and Answers: Session II: Mechanisms of
Neuroprotection (1).
.
Part III: Neuroprotection in Inflammation-Related
Neurodegenerative Diseases:.
15. Microglial NADPH Oxidase Mediates Leucine Enkephalin
Dopaminergic Neuroprotection: Liya Qin, Yuxin Liu, Xun Qian,
Jau-Shyong Hong, And Michelle L. Block.
16. Effect of Neuroprotective Drugs on Gene Expression in
G93A/SOD1 Mice: Sheila Ignacio, Dan H. Moore, Andrew P. Smith, And
Nancy M. Lee.
17. Brain Response to Injury and Neurodegeneration: Endogenous
Neuroprotective Signaling: Nicolas G. Bazan, Victor L. Marcheselli,
And Kasie Cole-Edwards.
18. Early Effects of Modulating Nuclear Factor-B Activation on
Traumatic Spinal Cord Injury in Rats: Octavio Jimenez-Garza,
Javier Camacho, Antonio Ibarra, Angelina Martinez, And Gabriel
Guizar-Sahagun.
19. Role of Inflammation in the Pathogenesis of Parkinson's
Disease: Models, Mechanisms, and Therapeutic Interventions:
Jau-Shyong Hong.
.
Part IV: Role of Carnitines and Other Agents in
Neuroprotection:.
20. Mechanisms of Ischemic Neuroprotection by
Acetyl-l-carnitine: Santina A. Zanelli, Nina J. Solenski, Robert E.
Rosenthal, and Gary Fiskum.
21. Identification of Rat Hippocampal mRNAs Altered by the
Mitochondrial Toxicant, 3-NPA: Beata D. Przybyla-Zawislak, Brett T.
Thorn, Syed F. Ali, Richard A. Dennis, Antonino Amato, Ashraf
Virmani, And Zbigniew K. Binienda.
22. l-Carnitine and Neuroprotection in the Animal Model of
Mitochondrial Dysfunction: Zbigniew Binienda, Beata
Przybyla-Zawislak, Ashraf Virmani, And Larry Schmued.
23. Effects of Metabolic Modifiers Such as Carnitines, Coenzyme
Q10, and PUFAs against Different Forms of Neurotoxic Insults:
Metabolic Inhibitors, MPTP, and Methamphetamine: Ashraf Virmani,
Franco Gaetani, And Zbigniew Binienda.
24. Questions and Answers: Session IV: Role of Carnitines and
Other Agents in Neuroprotection.
.
Part V: Neuroprotective Approaches and Models:.
25. The Antiapoptotic Actions of Mood Stabilizers: Molecular
Mechanisms and Therapeutic Potentials: De-Maw Chuang.
26. Circulatory Arrest as a Model for Studies of Global Ischemic
Injury and Neuroprotection: Lars Wiklund, Hari Shanker Sharma, and
Samar Basu.
27. Possible Neuroprotective Mechanism of Human Neuroglobin:
Keisuke Wakasugi, Chihiro Kitatsuji, And Isao Morishima.
28. The Impact of Aging, Dietary Restriction, and
Glucocorticoids on ApoE Gene Expression in Rat Brain: S Ruzdijic, M
Perovic, A Mladenovic, D Milanovic, L Rakic, S Petanceska, And S
Kanazir.
29. Questions and Answers: Session V: Neuroprotective Approaches
and Models.
.
Part VI: Neuroprotective Agents and Mechanisms.
30. Saposin C: Neuronal Effect and CNS Delivery by Liposomes:
Zhengtao Chu, Ying Sun, Chia Yi Kuan, Gregory A. Grabowski, And
Xiaoyang Qi.
31. Brain-Derived Neurotrophic Factor Is Neuroprotective against
Human Immunodeficiency Virus-1 Envelope Proteins: Alessia Bachis
And Italo Mocchetti.
32. Nicotinamide Modulates Energy Utilization and Improves
Functional Recovery from Ischemia in the In Vitro Rabbit Retina:
Diamond Tam, Majestic Tam, And Kenneth I. Maynard.
33. Mechanisms of Disease: Motoneuron Disease Aggravated by
Transgenic Expression of a Functionally Modified AMPA Receptor
Subunit: Rohini Kuner, Anthony J. Groom, Gerald Muller,
Hans-Christian Kornau, Vanya Stefovska, Iris Bresink, Bettina
Hartmann, Karsten Tschauner, Stefan Waibel, Albert C. Ludolph,
Chrysanthy Ikonomidou, Peter H. Seeburg, And Lechoslaw Turski.
34. Questions and Answers: Session VI: Neuroprotective Agents
and Mechanisms.
.
Part VII: The NMDA Receptor as a Target for Neurotoxicity and
Neuroprotection:.
35. Potentially Neuroprotective and Therapeutic Properties of
Nitrous Oxide and Xenon: Jacques H. Abraini, Helene N.
David, And Marc Lemaire.
36. Chronic Exposure to Nitrous Oxide Increases [3H]MK801
Binding in the Cerebral Cortex, but Not in the Hippocampus of Adult
Mice: Natascha Sommer, Carmelo Romano, and Vesna
Jevtovic-Todorovic.
37. Systems Biology/Systems Toxicology: Application to
Developmental Neurotoxicology/Neuroprotection: William Slikker,
Jr., Zengjun Xu, And Cheng Wang.
38. An Old Story with a New Twist: Do NMDAR1 mRNA Binding
Proteins Regulate Expression of the NMDAR1 Receptor in the Presence
of Alcohol?: Meena Kumari and Antje Anji.
39. Antioxidative Effect of Vitamin D3 on Zinc-Induced Oxidative
Stress in CNS: Anya M. Y. Lin, K B Chen, And P L Chao.
40. Questions and Answers: Session VII: The NMDA Receptor as a
Target for Neurotoxicity and Neuroprotection.
.
Part VIII: Mechanisms of Neuroprotection (2):.
41. Antioxidant Effects of N-Acetylserotonin: Possible
Mechanisms and Clinical Implications: Gregory Oxenkrug.
42. Novel Neuroprotective Mechanism of Action of Rasagiline Is
Associated with Its Propargyl Moiety: Interaction of Bcl-2 Family
Members with PKC Pathway: Orly Weinreb, Tamar Amit, Orit Bar-Am,
Orly Chillag-Talmor, and Moussa B. H. Youdim.
43. Gene Expression Profiling of Sporadic Parkinson's Disease
Substantia Nigra Pars Compacta Reveals Impairment of
Ubiquitin-Proteasome Subunits, SKP1A, Aldehyde Dehydrogenase, and
Chaperone HSC-70: Silvia Mandel, Edna Grunblatt, Peter Riederer,
Ninette Amariglio, Jasmine Jacob-Hirsch, Gideon Rechavi, and Moussa
B. H. Youdim.
44. Neuronal Growth-Promoting And Inhibitory Cues In
Neuroprotection And Neuroregeneration. By Stephen D. Skaper.
45. Immune-Modulating Effects of Melatonin, N-Acetylserotonin,
and N-Acetyldopamine: Mary C. Perianayagam, Gregory F. Oxenkrug,
and Bertrand L. Jaber.
46. N-Acetyldopamine Inhibits Rat Brain Lipid Peroxidation
Induced by Lipopolysaccharide: Gregory F. Oxenkrug and Pura J.
Requintina.
47. The In Vitro Effect of Estradiol and Testosterone on
Iron-Induced Lipid Peroxidation in Rat Brain and Kidney Tissues:
Pura J. Requintina and Gregory F. Oxenkrug.
48. Questions and Answers: Session VIII: Mechanisms of
Neuroprotection (2).
.
Part IX: Sensitive Targets for Neurotoxicity and
Neuroprotection:.
49. Neuroprotective Effects of Neurotrophins and Melanocortins
in Spinal Cord Injury: An Experimental Study in the Rat Using
Pharmacological and Morphological Approaches: Hari Shanker
Sharma.
50. Neuroprotective Effects of Nitric Oxide Synthase Inhibitors
in Spinal Cord Injury-Induced Pathophysiology and Motor Functions:
An Experimental Study in the Rat: Hari Shanker Sharma, Rajendra D.
Badgaiyan, Per Alm, S Mohanty, and Lars Wiklund.
51. Acrylamide Stimulates Glutamine Uptake in Fischer 344 Rat
Astrocytes by a Mechanism Involving Upregulation of the Amino Acid
Transport System N: Qi Wu, Marta Sidoryk, Lysette Mutkus, Magdalena
Zielinska, Jan Albrecht, and Michael Aschner.
52. Effects of Acrylamide on Primary Neonatal Rat Astrocyte
Functions: Michael Aschner, Qi Wu, and Marvin A. Friedman.
53. Neuroprotection by Platelet-Activating Factor Antagonism:
Xiaohua Tian and Nicolas G. Bazan.
54. Questions and Answers: Session IX: Sensitive Targets for
Neurotoxicity and Neuroprotection.
.
Part X: Novel Approaches to Neuroprotection:.
55. Expression of Prostaglandin E2 Synthases in Mouse Postnatal
Cortical Neurons: Valentina Echeverria, David L. Greenberg, and
Sylvain Dore.
56. Novel Neuroprotective Tripeptides and Dipeptides: Alan I.
Faden, Susan M. Knoblach, Vilen A. Movsesyan, Paul M. Lea, Iv, and
Ibolja Cernak.
57. Cocaine Induces a Differential Dose-Dependent Alteration in
the Expression Profile of Immediate Early Genes, Transcription
Factors, and Caspases in PC12 Cells: A Possible Mechanism of
Neurotoxic Damage in Cocaine Addiction: Syed Z. Imam, Helen M.
Duhart, John T. Skinner, and Syed F. Ali.
58. Neuroprotection in the PNS: Erythropoietin and Immunophilin
Ligands: Ahmet Hoke And Sanjay C. Keswani.
59. Questions and Answers: Session X: Novel Approaches to
Neuroprotection.
.
Part XI: Workshop PBPK/PD Models for Developing Humans: Risk
Assessment Strategies and Research Recommendations:.
60. Improving Predictive Modeling in Pediatric Drug Development:
Pharmacokinetics, Pharmacodynamics, and Mechanistic Modeling:
William Slikker, Jr., John F. Young, Richard A. Corley, David C.
Dorman, Rory B. Conolly, Thomas B. Knudsen, Brian L. Erstad,
Richard H. Luecke, Elaine M. Faustman, Charles Timchalk, and Donald
R. Mattison.
Index of Contributors
