| Mechanisms of Selective Vulnerability | |
| Mechanisms of Selective Toxicity in Neurodegenerative Disorders | p. 1 |
| The Dopamine Transporter: Involvement in Selective Dopaminergic Neurodegeneration | p. 17 |
| MPTP/MPP[superscript +] Action and Mechanism | |
| Advances in Our Knowledge of MPTP Action and Mechanism | p. 41 |
| Role of Microtubules in the Genesis of MPTP Neurotoxicity | p. 55 |
| Complex I Inhibition in Cultured Cells as Model for Parkinson's Disease | p. 59 |
| Nigral Degeneration in Animal Models of Multiple System Atrophy | p. 65 |
| Isoquinolines as Potential Neurotoxins | |
| Isoquinoline Neurotoxins | p. 69 |
| Apoptosis by an Endogenous Neurotoxin, N-Methyl(R)Salsolinol: Relevance to Parkinson's Disease | p. 77 |
| Isoquinolines in Parkinson's Disease | p. 91 |
| Systematic Studies of Dopamine and Dopamine-Derived Salsolinol and Norsalsolinol Levels in Various Human Brain Areas | p. 101 |
| Antidopaminergic Effects of Putative Endogenous MPTP-Like Agents: 1,2,3,4-Tetrahydroisoquinoline and 1-Methyl-6,7-Dihydroxy-1,2,3,4-Tetrahydroisoquinoline | p. 105 |
| Development of an HPLC-Method and Synthesis of 1,2,3,4-Tetrahydroisoquinolines as Reference Compounds for the Identification of Possible Neurotoxins in the Blood of Parkinson's Disease Patients | p. 111 |
| [beta]-Carbolines as Potential Neurotoxins | |
| [beta]-Carboline Analogues of MPP[superscript +] as Environmental Neurotoxins | p. 115 |
| N-Methyl-[beta]-Carbolinium Neurotoxins in Parkinson's Disease | p. 131 |
| 'TaClo', A Chloral-Derived Mammalian Alkaloid with Neurotoxic Properties | p. 145 |
| Nutritional Sources of Novel Tetrahydro-[beta]-Carbolines | p. 151 |
| Catecholamine-Oxidation Pathways in Neurotoxicity | |
| Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegeneration | p. 155 |
| Catecholamine-Derived Aldehyde Neurotoxins | p. 167 |
| Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dopamine and Its Oxidative Metabolites in the Pathogenesis of Parkinson's Disease | p. 181 |
| Neuromelanin May Mediate Neurotoxicity via its Interaction with Redox Active Iron | p. 211 |
| bcl-2 Protects SK-N-SH Cells from 6-Hydroxydopamine-Induced Apoptosis by Inhibition of Cytochrome c Redistribution | p. 219 |
| Generation of Neurotoxins by New Reaction Pathways of Dopamine under Oxidative Stress Conditions: Contributing Etiopathological Factors in Parkinson's Disease | p. 233 |
| Pesticides and Metals in Nigrostriatal Degeneration | |
| Relationship of Organochlorine Pesticides to Parkinsonism | p. 237 |
| Paraquat is a Model Environmental Neurotoxin for Studying Parkinson's Disease | p. 247 |
| Brain Iron and Other Trace Metals in Neurodegenerative Diseases | p. 259 |
| Mechanisms of Neuroprotection | |
| Contribution of Intracellular Non-Haem Iron, NF-[kappa]B Activation and Inflammatory Responses to Neurodegeneration in Parkinson's Disease: Prospects for Neuroprotection | p. 277 |
| Neurochemical Mechanisms Underlying Neuroprotective Actions of Bromocriptine, Salicylate, D- and L-Deprenyl in Neurodegeneration Caused by MPTP | p. 289 |
| Attenuation of Levodopa-Induced Toxicity in Primary Dopamine Neurons by Catechol-O-Methyltransferase Inhibition | p. 295 |
| Unilateral 6-Hydroxydopamine Lesions of Nigrostriatal Dopaminergic Neurons Increased Cannabinoid CB[subscript 1] Receptor mRNA Levels in the Rat Striatum: Possible Therapeutic Implications | p. 301 |
| Poster Abstracts | |
| Riluzole as a Neuroprotective Therapy in Animal Models of Parkinson's Disease | p. 309 |
| Progressive Reduction of the Rat Nigrostriatal Dopamine Metabolism Induced by Iron-III and TaClo | p. 310 |
| Brain N-Methylation of Indolic [beta]-Carbolines in Parkinsonism | p. 311 |
| Deleterious Effects of Highly Halogenated [beta]-Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respiration | p. 312 |
| Neuroprotective Role of Endogenous Adenosine in Methamphetamine-Induced Toxicity in Rat Striatum | p. 313 |
| New Taurine Analogues in Treatment Strategies for Parkinson's Disease | p. 315 |
| The Neurotoxicity of Manganese | p. 316 |
| Organotypic Striatal Slices: Neuroprotective Effects of Vitamins | p. 317 |
| Impairment of Energy Metabolism is Not Responsible for Cytotoxicity of 6-Hydroxydopamine towards Human SH-SY5Y Dopaminergic Neuroblastoma Cells | p. 318 |
| Development of a Sensitive and Selective GC/MS Method for the Determination of Tetrahydro-[beta]-Carbolines in Urine Samples. Occurrence of Some of these Compounds in the Urine of Parkinson's Disease Patients | p. 319 |
| Chronic Treatment with 1,2,3,4-Tetrahydroisoquinoline (TIQ), an Environmental and Endogenous Substance, Induces Parkinsonian-Like Muscle Rigidity in Young and Old Rats | p. 320 |
| Propargylamines Protect Dopamine Cells from Apoptosis Induced by a Neurotoxin, N-Methyl(R) Salsolinol | p. 321 |
| 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine and 1-Methyl-4-Phenylpyridinium Ions have Opposite Effects on Membrane Currents of Cultured Dorsal Root Ganglia Neurons | p. 322 |
| The Effects of Catecholic and O-methylated Tetrahydroisoquinolines on the Production of Hydroxyl Radical | p. 323 |
| Differential Cytotoxicity of Isoquinolines in HEK-293 Cells Stably Transfected with the Dopamine Transporter Gene | p. 324 |
| HEK-293 Cells Expressing the Human Dopamine Transporter Are Susceptible to Low Concentrations of 1-Methyl-4-Phenylpyridinium (MPP[superscript +]) via Impairment of Energy Metabolism | p. 325 |
| Opposite Effects of Simple Tetrahydroisoquinolines on Amphetamine and Morphine-Stimulated Locomotor Activity in Mice | p. 326 |
| Neurological Disorders--Acetylcholine Mimics and Their Role as Uncompetitive Inhibitors of Esterases | p. 327 |
| Nicotinic Acetylcholine Receptor Agonist Activity of Isoquinoline Alkaloids | p. 328 |
| Effects of TaClo (1-Trichloromethyl-1,2,3,4-Tetrahydro-[beta]-Carboline) on Mice Neuronal Culture and Possibilities of Cellular Regeneration In Vitro after Toxin Withdrawal | p. 329 |
| Index | p. 331 |
| Index of Contributors | p. 339 |
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