List of Contributors.
Preface.
1 The Role of the Cambridge Structural Database in Crystal
Engineering (Andrew D. Bond).
1.1 Introduction.
1.2 Organisation and Management of Crystallographic
Information.
1.3 Organisation of Crystallographic Information for Crystal
Engineering.
1.4 New Tools for Database Research.
1.5 Search for Functional Group Exchanges: GRX.
1.6 Search for Solvated and Unsolvated Structures: Solvates.
1.7 Clustering and Classifying CSD Search Results: dSNAP.
1.8 The PXRD Profile as a Structural Descriptor.
1.9 Identifying Supramolecular Constructs: XPac.
1.10 Concluding Remarks: the Future Role of Crystallographic
Databases.
References.
2 Computational Crystal Structure Prediction: Towards In
Silico Solid Form Screening (Graeme M. Day).
2.1 Introduction.
2.2 Methods used to Predict Crystal Structures.
2.3 Current Capabilities of Crystal Structure Prediction.
2.4 Exploration of Crystal Forms. A Case Study:
Carbamazepine.
2.5 Summary.
Acknowledgments.
References.
3 Multi-component Pharmaceutical Crystalline Phases:
Engineering for Performance (Matthew L. Peterson, Edwin A.
Collier, Magali B. Hickey, Hector Guzman and Örn
Almarsson).
3.1 Introduction.
3.2 Exploring Crystal Form Diversity.
3.3 High-throughput Experimentation.
3.4 Examples of ?Form and Formulation?.
3.5 AMG517 and Celecoxib ? ?Spring and
Parachute? Approach.
3.6 Carbamazepine - Stabilization Against a Hydrate.
3.7 Theophylline:Phenobarbital - Two is Better Than One.
3.8 Delaviridine Mesylate - Material Misbehavior.
3.9 Summary and Outlook.
References.
4 Complex Formation of Surfactants with Aromatic Compounds
and their Pharmaceutical Applications (Yuji Ohashi, Keiju
Sawada and Nahoko Iimura).
4.1 Introduction.
4.2 Structures of the Complexes Formed Between Surfactants and
Aromatic Compounds.
4.3 Complex Formation of Aromatic Compounds Containing an Hetero
Ring.
4.4 Complex Formation of Biphenyl with Cationic Surfactants.
4.5 Complex Formation of Odd-Number Surfactants with
Biphenyl.
4.6 Common Packing Mode in the Complexes.
4.7 Complex Formation by Grinding in a Mortar.
4.8 C-H...p interactions.
4.9 Complex Formation of Anionic Surfactants with Aromatic
Compounds.
4.10 Increased Solubility of Insoluble Drugs.
4.11 Enhanced Thermal Stability of Perfumes.
4.12 Complex Formation with Surfactants other than Quaternary
Alkylammonium Salts.
4.13 Hydroquinone Complexes.
4.14 Application to Whitening Agents.
Acknowledgments.
References.
5 Hydrogen Bonding and Molecular Packing in Multi-Functional
Crystal Structures (Ashwini Nangia).
5.1 Introduction.
5.2 Hydrogen Bonding in Ureas and Amides.
5.3 Pyridyl Ureas and Amides.
5.4 Nitrophenyl Ureas and Amides.
5.5 Molecular Conformation and Hydrogen Bonding.
5.6 Supramolecular HSAB Interactions.
5.7 gem-alkynols.
5.8 Conclusions.
Acknowledgments.
References.
6 Persistence of N-H...S Hydrogen Bonding in Thiocarbamide
Structures (Edward R. T. Tiekink).
6.1 Introduction.
6.2 Supramolecular Aggregation Patterns in the
Thiocarbamides.
6.3 Conclusions.
References.
7 Crystal Engineering with the Molecules Containing Amide and
Pyridine Functionalities (Kumar Biradha and Lalit
Rajput).
7.1 Introduction.
7.2 Primary Amides Containing the Pyridine Moiety.
7.3 Co-crystals with Primary Amidopyridines.
7.4 Secondary Amides Containing a Pyridine Moiety.
7.5 Bis-Amidopyridine Derivatives.
7.6 Two-component Structures Containing Secondary Amides and
Pyridine Derivatives.
7.7 Triamidopyridine Derivatives.
7.8 Conclusions.
Acknowledgements.
References.
8 Urea/Thiourea-Anion Host Lattices, Stabilization of Labile
Species, and Designed Construction of Rosette Ribbon and Layers
(Thomas C. W. Mak, Chi-Keung Lam, Jie Han, Qi Li and Feng
Xue).
8.1 Introduction.
8.2 Inclusion Compounds with Urea/Thiourea-Anion Host
Lattices.
8.3 Stabilization of Cyclic Oxocarbon Dianions by Hydrogen
Bonding with Urea/Thiourea.
8.4 Supramolecular Assembly Based on the Rosette Motif.
8.5 Conclusion and Outlook.
Acknowledgments.
References.
Index.
