Particle Therapy Technology for Safe Treatment - Jay Flanz

Particle Therapy Technology for Safe Treatment

By: Jay Flanz

Paperback | 29 January 2024

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The path from clinical requirements to technical implementation is filtered by the translation of the modality to the technology. An important part of that filter is that the modality be safe. For that to be the case, it is imperative to understand what clinical parameters affect the safety of a treatment and then determine how the technology can affect those parameters.

This book provides a practical introduction to particle therapy. It provides a thorough introduction to the technological tools and their applications and then details the components that are needed to implement them. It explains the foundations of beam production and beam delivery that serve to meet the necessary clinical requirements. It emphasizes the relationship between requirements and implementation, including how safety and quality are considered and implemented in the solution. The reader will learn to better understand what parameters are important to achieve these goals.

Particle Therapy Technology for Safe Treatment will be a useful resource for professionals in the field of particle therapy in addition to biomedical engineers and practitioners in the field of beam physics. It can also be used as a textbook for graduate medical physics and beam physics courses.

Key Features

  • Presents a practical and accessible journey from application requirements to technical solutions
  • Provides a pedagogic treatment of the underlying technology
  • Describes how safety is to be considered in the application of this technology and how safety and quality can be factored into the overall system

Author Bio

After receiving his PhD in nuclear physics, Dr. Jacob Flanz was the Accelerator Physics Group leader and Principal Research Scientist at the Massachusetts Institute of Technology (MIT), USA, where he designed the recirculator and the GeV stretcher/storage ring. He joined Massachusetts General Hospital (MGH) and Harvard and became project and technical director of proton therapy, with responsibility for specifications, integration, and commissioning ensuring safe clinical performance. He invented the universal nozzle and led the design and implementation of beam scanning at MGH in 2008, including quality assurance. Dr. Flanz has been involved in several FDA applications for particle therapy. He developed and taught the US Particle Accelerator School course "Medical Applications of Accelerators and Beams." He was cochair of education and is currently the president of the Particle Therapy Co-Operative Group.

Exercise solutions to accompany this book can be accessed via the 'Instructor Resources' tab on the book webpage.

Industry Reviews

"The book is a very personal (including many photos of his beautiful family) textbook/handbook by a particle therapy physicist who has about 45 years of experience honing his personal notes on the field through participation in many of the annual National Particle Therapy Schools as well as teaching at MGH and associations such as the AAPM and the Particle Therapy Cooperative Oncology Group (PTCOG). The author, Jay Flanz, is an MIT particle accelerator physicist who made the transition into a particle beam physicist at the start of the hospital-based proton radiotherapy era. There are few others who have seen this field's infancy and have stayed through to the present day...

The book begins by giving the reader both the evolution of particle accelerators and therapy as well as a very personal historical view by the author. The book then presents "get-up-to speed quickly" chapters on topics like setting requirements and components for particle therapy, radiation biology, basic review of the math needed, relativity, and charged particle interactions in matter with or without the presence of a magnetic field. While most medical physicists would skip over these chapters it can be argued to be extremely valuable for someone with an engineering background to read thoroughly anything that was not well known to them...The book is written for physicists, physical scientists, and engineers to give them the practical theory and knowledge so that "nothing goes wrong" for what are inarguably the most complex treatment systems ever devised. The book's title incorporates the word "safety" to emphasize that safety goes before all else. Many of his chapters end with a section called "What Could Go Wrong?"... If you are a medical physicist working in particle or insist your library order it this is a very useful book for physical scientists and engineers who are or want to be involved in particle beam radiation therapy."
-Thomas Rockwell Mackie, PHD, in Medical Physics, The International Journal of Medical Physics Research and Practice (July 2022)


"The book is a very personal (including many photos of his beautiful family) textbook/handbook by a particle therapy physicist who has about 45 years of experience honing his personal notes on the field through participation in many of the annual National Particle Therapy Schools as well as teaching at MGH and associations such as the AAPM and the Particle Therapy Cooperative Oncology Group (PTCOG). The author, Jay Flanz, is an MIT particle accelerator physicist who made the transition into a particle beam physicist at the start of the hospital-based proton radiotherapy era. There are few others who have seen this field's infancy and have stayed through to the present day...

The book begins by giving the reader both the evolution of particle accelerators and therapy as well as a very personal historical view by the author. The book then presents "get-up-to speed quickly" chapters on topics like setting requirements and components for particle therapy, radiation biology, basic review of the math needed, relativity, and charged particle interactions in matter with or without the presence of a magnetic field. While most medical physicists would skip over these chapters it can be argued to be extremely valuable for someone with an engineering background to read thoroughly anything that was not well known to them...The book is written for physicists, physical scientists, and engineers to give them the practical theory and knowledge so that "nothing goes wrong" for what are inarguably the most complex treatment systems ever devised. The book's title incorporates the word "safety" to emphasize that safety goes before all else. Many of his chapters end with a section called "What Could Go Wrong?"... If you are a medical physicist working in particle or insist your library order it this is a very useful book for physical scientists and engineers who are or want to be involved in particle beam radiation therapy."

-Thomas Rockwell Mackie, PHD, in Medical Physics, The International Journal of Medical Physics Research and Practice (July 2022)

"This book provides a nice overview of the fundamentals of particle therapy technology with emphasis on treatment safety. As particle therapy is an ever-evolving field, this book will be a valuable reference ensuring knowledge transfer from a subject matter expert to the next generation of particle therapy physicists. Readers will find this book useful for a deeper understanding of application of particles, mainly protons, in radiation therapy."

- Arash Darafsheh, Ph.D., Washington University School of Medicine

"This book provides a practical introduction to particle therapy technology, covering the fundamental aspects of beam production and delivery systems that serve to meet specific clinical requirements. Safe particle therapy delivery requires understanding basic principles of

operating the equipment, which components or parameters impact the output beam, and how they do that. The book aims to provide such

information and also pass down lessons learned to the next generation. This book is an important contribution for particle therapy professionals

worldwide. The intended audience includes professionals in the field of particle therapy, biomedical engineers, and practitioners in the field of beam physics. The book can also serve as a supplementary reference for medical physics graduate students and residents. The author is a highly

recognized expert in the field of particle therapy.

This book provides a nice overview of the fundamentals of particle therapy technology with emphasis on treatment safety. As particle

therapy is an ever-evolving field, this book will be a valuable reference ensuring knowledge transfer from a subject matter expert to the next

generation of particle therapy physicists. Readers will find this book useful for a deeper understanding of application of particles, mainly

protons, in radiation therapy."

-Arash Darafsheh, Ph.D. (Washington University, School of Medicine) in Doody's Core Titles Review 2023.

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